Inflammation Basic Principles and Clinical Correlates

by Gallin, John I.; Snyderman, Ralph; Fearon, Douglas T.; Haynes, Barton F.; Nathan, Carl

• ISBN13: 9780397517596
• ISBN10: 0397517599
• Edition: 3rd
• Format: Hardcover
• Copyright: 1999-04-20
• Publisher: LWW

Summary

The Third Edition of this classic text has been completely revised and updated and greatly expanded in scope. With three new associate editors and over 20 new chapters, the book provides comprehensive coverage of the inflammatory process, its clinical manifestations, and its pharmacologic modulation. This edition includes vital new information on cytokines and cytokine receptors, signal transduction, mechanisms of cellular adhesion, angiogenesis, and wound healing. The "Clinical Correlates" section features new chapters on autoantibodies, sepsis and septic shock, reperfusion injury, type 1 diabetes, inflammation and cancer, cancer immunology, and induction of inflammation by Helicobacter pylori. The section on therapeutic modulation of inflammation includes new chapters on complement inhibitors, cytokine inhibitors, agents targeting transcription factors, and emerging technologies for the discovery of small-molecule therapeutics. Other new chapters in this section cover second line antirheumatic drugs, tolerance to anti-inflammatory drugs, immunomodulation by intravenous gammaglobulin, and antimicrobial peptides.

Table of Contents

Contributors	xii
Preface	xxiii
Acknowledgments	xxiv
Overview	1	(4)
John I. Gallin
Ralph Snyderman
Inflammation: Historical Perspectives	5	(8)
Ramzi S. Cotran
Part I: Cellular Components of Inflammation
Developmental Biology of Neutrophils and Eosinophils	13	(22)
Dorothy Ford Bainton
Development and Distribution of Mononuclear Phagocytes: Relevance to Inflammation	35	(14)
Siamon Gordon
Dendritic Cells	49	(12)
Ralph M. Steinman
Nina Bhardwaj
Eosinophils	61	(16)
Helene F. Rosenberg
Platelets: Their Role in Hemostasis, Thrombosis, and Inflammation	77	(20)
Aaron J. Marcus
Mast Cells and Basophils	97	(22)
Gunnar Nilsson
John J. Costa
Dean D. Metcalfe
Overview of Development and Function of Lymphocytes	119	(18)
Laura P. Hale
Barton F. Haynes
The Thymus and T-Cell Development	137	(14)
Charles D. Surh
Jonathan Sprent
B-Cell Development	151	(16)
Kong-Peng Lam
Klaus Rajewsky
Natural Killer Cells	167	(10)
Lorenzo Moretta
Maria Cristina Mingari
CD4 Effector Cells	177	(8)
Sergio Romagnani
CD8 Effector Cells	185	(6)
Norman L. Letvin
Jorn E. Schmitz
Role of Co-Stimulation in the Host Response to Infection	191	(16)
Kelvin P. Lee
David M. Harlan
Carl H. June
The Vascular Endothelium	207	(20)
Roy L. Silverstein
Fibroblasts and Matrix Proteins	227	(32)
Arnold E. Postlethwaite
Andrew H. Kang
Extracellular Matrix Proteins and Proteoglycans	259	(8)
Erkki Ruoslahti
Part II: Mediators of Inflammation
Immunoglobulins	267	(14)
Robyn L. Stanfield
Ian A. Wilson
Biology of the Complement System	281	(36)
Neil R. Cooper
Acute Phase Response	317	(14)
Irving Kushner
Debra Rzewnicki
Bradykinin Formation: Plasma and Tissue Pathways and Cellular Interactions	331	(18)
Allen P. Kaplan
Kusumam Joseph
Yoji Shibayama
Yoshitaka Nakazawa
Berhane Ghebrehiwet
Sesha Reddigari
Michael Silverberg
Prostaglandins and Inflammation	349	(12)
Richard J. Griffiths
Leukotrienes: Biosynthetic Pathways, Release, and Receptor-Mediated Actions with Relevance to Disease States	361	(12)
John F. Penrose
K. Frank Austen
Bing K. Lam
Lipoxins and Aspirin-Triggered 15-epi-Lipoxins	373	(14)
Charles N. Serhan
Platelet-Activating Factor: A Phospholipid Mediator of Inflammation	387	(10)
Stephen M. Prescott
Thomas M. McIntyre
Guy A. Zimmerman
Neuropeptides in Inflammation and Immunity	397	(8)
Richard D. Granstein
Myeloid Growth Factors	405	(14)
Donald Metcalf
Chemokines	419	(14)
Macro Baggiolini
Beatrice Dewald
Bernhard Moser
Cytokines in Normal and Pathogenic Inflammatory Responses	433	(10)
John S. Sundy
Dhavalkumar D. Patel
Barton F. Haynes
Interleukin-1: A Proinflammatory Cytokine	443	(20)
Charles A. Dinarello
Interleukin-2	463	(8)
Kendall A. Smith
Carol Beadling
Elizabeth Leef Jacobson
Tumor Necrosis Factor, Interleukin-6, Macrophage Migration Inhibitory Factor, and Macrophage Inflammatory Protein-1 in Inflammation	471	(16)
Haichao Wang
Kevin J. Tracey
Biochemistry, Mechanism of Action, and Biology of the Interferons	487	(18)
Erika A. Bach
Daniel H. Kaplan
Robert D. Schreiber
Interleukin-12	505	(10)
Giorgio Trinchieri
Part III: Cellular Mechanisms
Receptors for Microbial Products: Carbohydrates	515	(10)
Iain P. Fraser
R. Alan B. Ezekowitz
Innate Recognition of Microbial Lipids	525	(12)
Samuel D. Wright
The Role of Β2 Integrins in Inflammation	537	(34)
Takashi Kei Kishimoto
Eric T. Baldwin
Donald C. Anderson
The Selectins in Inflammation	571	(14)
Lisa A. Robinson
Douglas A. Steeber
Thomas F. Tedder
Leukocyte-Endothelial Cell Adhesion Molecules in Transendothelial Migration	585	(8)
William A. Muller
Molecular Basis of Lymphocyte Migration	593	(14)
Douglas A. Steeber
Thomas F. Tedder
Chemoattractant Stimulus-Response Coupling	607	(20)
Ronald J. Uhing
Ralph Snyderman
Signal Transduction in Lymphocytes	627	(12)
Gary A. Koretzky
Ion Channels and Carriers in Leukocytes: Distribution and Functional Roles	639	(22)
Thomas E. DeCoursey
Sergio Grinstein
Mechanical Responses of White Blood Cells	661	(20)
Thomas P. Stossel
Biology of Phagocytosis	681	(22)
Steven Greenberg
Degranulation	703	(18)
Giorgio Berton
Oxygen Metabolites from Phagocytes	721	(48)
Seymour J. Klebanoff
The Respiratory Burst Oxidase	769	(18)
Thomas L. Leto
Nitric Oxide as a Factor in Inflammation	787	(14)
Eeva Moilanen
Brendan Whittle
Salvador Moncada
Oxygen-Independent Antimicrobial Systems of Phagocytes	801	(18)
Peter Elsbach
Jerrold Weiss
Ofer Levy
Apoptosis and Senescence of Hematopoietic and Immune Cells: Mechanisms and Significance	819	(32)
Lina M. Obein
Yusuf A. Hannun
Role of Interleukin-10, Interleukin-4, and Interleukin-13 in Resolving Inflammatory Responses	851	(1)
Rene de Waal Malefyt
Angiogenesis	851	(14)
Douglas A. Arenberg
Robert M. Strieter
Wound Repair: An Overview	865	(18)
Salah Chettibi
Mark W. J. Ferguson
Transforming Growth Factor-Β (TGF-Β) in the Resolution and Repair of Inflammation	883	(12)
Sharon M. Wahl
Part V: Clinical Correlates
Disorders of Phagocytic Cells	895	(20)
Steven M. Holland
John I. Gallin
Urticaria and Angioedema	915	(14)
Allen P. Kaplan
Role of Immunoglobulin E and Eosinophils in Mediating Protection and Pathology in Parasitic Helminth Infections	929	(8)
Amy D. Klion
Myriam Armant
Thomas B. Nutman
Autoantibodies: Their Induction and Pathogenicity	937	(12)
Gisele Zandman-Goddard
Betty Diamond
Pemphigus and Pemphigoid: Autoantibody-Mediated Dermatoses	949	(16)
Hossein C. Nousari
Gerald S. Lazarus
Grant J. Anhalt
The Role of Infammation in Sepsis and Septic Shock: A Meta-analysis of Both Clinical and Preclinical Trials of Anti-inflammatory Therapies	965	(12)
Bradley D. Freeman
Peter Q. Eichacker
Charles Natanson
Granulomatous Inflammation: Host Antimicrobial Defense in the Tissues in Visceral Leishmaniasis	977	(18)
Henry W. Murray
Vasculitis: Pathogenic Mechanisms of Vessel Damage	995	(22)
John S. Sundy
Barton F. Haynes
Rheumatoid Arthritis	1017	(22)
Arthus F. Kavanaugh
Peter E. Lipsky
Crystal-Induced Arthropathies	1039	(8)
Shaun R. McColl
Paul H. Naccache
Reperfusion Injury	1047	(14)
Kenneth S. Kilgore
Robert F. Todd III
Benedict R. Lucchesi
Inflammatory Lung Disease: Molecular Determinants of Emphysema, Bronchitis, and Fibrosis	1061	(22)
Khavar J. Dar
Ronald G. Crystal
Atherogenesis	1083	(14)
Russell Ross
Type I Diabetes Mellitus	1097	(10)
Charles A. Janeway
Robert S. Sherwin
Persistent Mucosal Colonization by Helicobacter pylori and the Induction of Inflammation	1107	(10)
Martin J. Blaser
Phillip D. Smith
Inflammation and Cancer	1117	(14)
Hans Schreiber
Donald A. Rowley
Cancer Immunology	1131	(28)
Drew M. Pardoll
Part VI: Therapeutic Modulation of Inflammation
Agents Targeting Transcription Factors	1159	(18)
Anthony M. Manning
Anjana Rao
Inhibitors and Antagonists of Cyclooxygenase, 5-Lipoxygenase, and Platelt Activating Factor	1177	(18)
Henry J. Showell
Kelvin Cooper
Complement Inhibitors	1195	(12)
Jeffrey L. Platt
Cytokine Inhibitors: Biologics	1207	(6)
Marc Feldmann
Emerging Technologies for the Discovery of Small-Molecule Therapeutics	1213	(14)
Ian A. MacNeil
Mark J. Zoller
Second-Line Antirheumatic Drugs	1227	(12)
Bruce N. Cronstein
Peptide-Induced Tolerance	1239	(12)
Halina Offner
Arthur A. Vandenbark
Oral Tolerance	1251	(12)
Howard L. Weiner
Immunomodulation by Intravenous Immune Globulin	1263	(16)
Richard I. Schiff
Antimicrobial Peptides: Complementing Classical Inflammatory Mechanisms of Defense	1279	(14)
Mark Anderson
Michael Zasloff
Appendix A. Human Leukocyte Surface Antigens	1293	(10)
Dhavalkumar D. Patel
Barton F. Haynes
Appendix B: Cytokines and Cytokine Receptors	1303	(6)
John S. Sundy
Dhavalkumar D. Patel
Barton F. Haynes
Subject Index	1309