Inflammation and Cardiac Diseases

by Feuerstein, Giora Z.; Libby, Peter, M.D.; Mann, Douglas L.; Mann, Douglas L.

• ISBN13: 9783764367251
• ISBN10: 3764367253
• Format: Hardcover
• Copyright: 2003-11-01
• Publisher: Birkhauser

Summary

Heart failure research is a most active area of research in academic, industrial and government-sponsored research and receives intense clinical attention. The recent recognition that inflammation is a risk factor and prognostic factor for heart disease has laid ground for preventive medicine and even anti-infective strategies in prevention and treatment of heart failure.

Table of Contents

List of contributors	ix
Introduction
Inflammation -- a new frontier in cardiac disease and therapeutics	1	(8)
Giora Z. Feuerstein
Peter Libby
Douglas L. Mann
Pathological aspects and inflammation biomarkers in cardiac diseases
A biomarker of inflammation in cardiovascular diseases	9	(12)
Giora Z. Feuerstein
Ron Firestein
Douglas L. Mann
Peter Libby
Inflammation and coronary artery disease	21	(36)
Renu Virmani
Frank D. Kolodgie
Allen P. Burke
Andrew Farb
Herman K. Gold
Aloke V. Finn
Inflammatory cells and their metalloproteinases in cardiac diseases
The role of matrix metalloproteinases in LV remodeling following myocardial infarction	57	(20)
Esther E.J.M. Creemers
Jack P.M. Cleutjens
Jos F.M. Smits
Mat J.A.P. Daemen
Matrix metalloproteinases in heart failure: evidence from experimental models	77	(18)
Francis G. Spinale
Inflammatory cytokines in cardiac diseases
The clinical experience with anti-cytokine therapy in heart failure	95	(16)
Anita Deswal
Biykem Bozkurt
Douglas L. Mann
The role of IL-6 and related cytokines in myocardial remodeling and inflammation -- implication for cardiac hypertrophy and heart failure	111	(18)
Antoine Bril
Giora Feuerstein
Toll-like receptors and the cardiovascular system	129	(14)
Stefan Frantz
Ralph A. Kelly
Todd Bourcier
The role of IL-6 in experimental and clinical heart failure	143	(12)
Elaine J. Tanhehco
Hani N. Sabbah
Oxygen and nitrogen reactive radicals in cardiac inflammation and disease
Myocardial nitric oxide in cardiac remodeling	155	(16)
Flora Sam
Douglas B. Sawyer
Wilson S. Colucci
Identification and role of inflammatory oxygen free radicals in cardiac ischemia and reperfusion injury	171	(18)
Catherine Vergely
Gaelle Clermont
Sandrine Lecour
Antoine Bril
Luc Rochette
The immune and complement system and cardiac diseases
Immune-mediated myocarditis and interleukin-10	189	(14)
Kenichi Watanabe
Makoto Kodama
Yoshifusa Aizawa
Immunomodulation in heart failure: experimental models	203	(18)
Shigetake Sasayama
The role of complement in myocardial inflammation and reperfusion injury	221	(30)
Elaine J. Tanhehco
Benedict R. Lucchesi
Inflammatory signaling pathways in cardiac diseases
The role of immune and inflammatory cytokines in ischemic preconditioning of the heart -- identification of novel cardiac cell survival signaling programs	251	(20)
Sandrine Lecour
Robert M. Smith
Michael N. Sack
Stress-activated signals and their role in myocardial ischemia	271	(22)
Masaya Tanno
Michael Marber
p38 MAPK in cardiac remodeling and failure: cytokine signaling and beyond	293	(22)
Thomas M. Behr
Christopher P. Doe
Haisong Ju
Robert N. Willette
Inflammation and myocarditis
Inflammation and myocarditis	315	(10)
Jay W. Mason
The inflammatory process in experimental myocarditis	325	(12)
Noel R. Rose
Marina Afanasyeva
Nuclear factors in cardiac disease
Peroxisome proliferator activated receptors, inflammation, the vasculature and the heart	337	(14)
Quy N. Diep
Farhad Amiri
Ernesto L. Schiffrin
Chemokines and cardiac diseases
Role of chemokines in the pathogenesis of congestive heart failure	351	(20)
Joseph Winaver
Thomas M. Behr
Zaid Abassi
Neurohormonal mediators and cardiac inflammation
The role of endothelin-1 in myocardial inflammation and fibrosis	371	(16)
Li L. Yang
Mansoor Husain
Duncan J. Stewart
Cyclooxygenases and cardiac diseases
Cyclo-oxygenase-2 and myocardial ischemia	387	(12)
Gary F. Baxter
Caroline P.D. Wheeler-Jones
Inflammation and arrhythmias
Inflammation as a cause and consequence of atrial fibrillation	399	(8)
David R. Van Wagoner
Mina K. Chung
Summary: Immune and inflammatory modulators as potential therapeutic targets for cardiac diseases	407	(4)
Giora Z. Feuerstein
Peter Libby
Douglas L. Mann
Index	411