Inflammatory Bowel Disease Translating Basic Science into Clinical Practice

by Targan, Stephan R.; Shanahan, Fergus; Karp, Loren C.

• ISBN13: 9781405157254
• ISBN10: 1405157259
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-05-24
• Publisher: Wiley-Blackwell

Summary

This is the state-of-the-art book on inflammatory bowel disease you have been waiting forWritten and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD.In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine.This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

Author Biography

Stephan R. Targan, MD Director, Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute, and Division of Gastroenterology, Los Angeles, CA, USA
Fergus Shanahan, MD Professor and Chair, Department of Medicine and Director, Alimentary Pharmabiotic Centre, University College Cork, National University of Ireland; Professor, Department of Medicine, Cork University Hospital, Cork, Ireland
Loren c. Karp Researcher/Specialist, Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, CA, USA

Table of Contents

List of Contributors

Preface

Overview of inflammatory bowel diseases: from bench to bedside and back

Heterogeneity of inflammatory bowel diseases

Epidemiology: the changing faces of Crohn's disease and ulcerative colitis

Genetics of inflammatory bowel disease

Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanisms

The normal intestinal mucosa: a state of "controlled" inflammation

Innate immunity

Adaptive immunity (novel effector cells/TGF SMAD)

The bacterial/epithelial/lymphocyte interface

Cytokines and chemokines in mucosal homeostasis

Role of the microcirculation in chronic gut inflammation

Remission, relapse, intestinal healing and repair

Pathophysiology of inflammatory bowel disease: the bidirectional relationship of gut physiological systems and the mucosal immune system

Pathogenesis: systemic consequences of intestinal inflammation

Clinical course and complications of ulcerative colitis and ulcerative proctitis

Clinical features and complications of Crohn's disease

Practical IBD pathology in patient management

An endoscopist's perspective of diagnosis: when, where and what?

Imaging in inflammatory bowel disease: CT and MR enterography, ultrasound, and enteroscop

New diagnostic approaches integrating serologics endoscopy and radiology and genomics)

Differential diagnosis of colitis

Issues related to practice guidelines, reimbursement, drug rationing in the US and Europe

Pharmacoeconomic outcomes/disease activity indices/study design

Muti-site therapeutic modalities for inflammatory bowel diseases: mechanisms of action, combination therapy

Site specific therapeutics for inflammatory bowel diseases

Therapeutic manipulation of the microbiota in inflammatory bowel disease: antibiotics and probiotics

Nutrition and inflammatory bowel diseases

Medical management of ulcerative colitis

Surgical management of ulcerative colitis

Clinical characteristics and management of pouchitis and ileal pouch disorders

Medical management of Crohns disease

Surgical treatment of Crohns disease/perianal Crohns disease

Management of post-operative prevention of recurrence in Crohns disease

The molecular pathology of IBD-associated neoplasia and preneoplasia

Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance method

Hepatobiliary diseases in patients with inflammatory bowel diseases

Articular and ocular complications of inflammatory bowel diseases

Cutaneous manifestations of inflammatory bowel diseases

Fertility and pregnancy in inflammatory bowel diseases

Special considerations in pediatric inflammatory bowel diseases

Collagenous and lymphocytic colitis

IBD microcirculation and diversion, diverticular and other non-infectious colitides

Clostridium difficile associated diarrhea

Infectious colitis

Human immunodeficiency virus and inflammatory bowel diseases

Bone metabolism and inflammatory bowel disease

Comprehensive approach to patient risk: risks versus benefits of immunomodulators and biologic therapy for IBD

Complementary medicine

Legal pitfalls in treating IBD patients

The present and future of research and treatment of inflammatory bowel disease

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