Inflammatory Diseases of the Central Nervous System

by Edited by Trevor Kilpatrick , Richard M. Ransohoff , Steven Wesselingh

• ISBN13: 9780521888745
• ISBN10: 0521888743
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-11-30
• Publisher: Cambridge University Press

Summary

Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists.

Table of Contents

Preface

Interactions Between the Immune and Nervous Systems

Effectors and determinants of the innate and adaptive immune responses

Microglia: protective and pathogenic mediators

The role of dendritic cells in neuroinflammation

Negotiating the brain barriers: access of immune cells and pathogens into the CNS

Autoimmunity

Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders

Multiple sclerosis: neuroimmune crosstalk in acute and progressive stages of the disease

CD8+ T Cell-mediated autoimmune diseases in the CNS

Acute disseminated encephalomyelitis: determinants and manifestations

Primary angiitis of the CNS and its mimics

Microbiological and Traumatic Challenges to the CNS

Acute viral encephalitis: role of the immune system in viral clearance from the CNS and in the generation of pathology

Chronic HIV infection of the CNS: role of the immune system in virological control and the generation of pathology

Brain inflammation during bacterial meningitis

Parasitic infections of the brain: malaria and beyond

Role of the inflammatory process in traumatic brain damage

Therapy

HIV-associated neurocognitive disorders: clinical features and therapeutic challenges

Role of immunomodulation in management of infections of the CNS

Neuroinflammation: an emerging therapeutic target in neurological disease

Index

Table of Contents provided by Publisher. All Rights Reserved.