Inflammatory Disorders Of The Nervous System

by Minagar, Alireza; Alexander, J. Steven, Ph.D.

• ISBN13: 9781588294241
• ISBN10: 1588294242
• Format: Hardcover
• Copyright: 2005-06-30
• Publisher: Humana Pr Inc

Summary

A cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.

Table of Contents

Series Editor's Introduction	v
Preface	vii
Contributors	xi
Continuing Medical Education	xiii
Endothelial Cell--Leukocyte Interactions During CNS Inflammation	1	(16)
J. Steven Alexander
Alireza Minagar
Multiple Sclerosis: A Disease of Miscommunication Between the Immune and Central Nervous Systems?	17	(24)
Monica J. Carson
Crystal S. Anglen
Corinne Ploix
Cytokines and Brain: Health and Disease	41	(40)
Tammy Kielian
Paul D. Drew
Chemokines and Central Nervous System Disorders	81	(10)
William J. Karpus
Circulating Cell-Derived Microparticles in Thrombotic and Inflammatory Disorders	91	(12)
Wenche Jy
Lawrence L. Horstman
Joaquin J. Jimenez
Alireza Minagar
Yeon S. Ahn
Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Clinical Management	103	(30)
William A. Sheremata
Neuroprotective Effects of Interferon-β in Multiple Sclerosis	133	(14)
Fabrizio Giuliani
Rana Zabad
V. Wee Yong
Acute Disseminated Encephalomyelitis	147	(16)
Sean J. Pittock
Dean M. Wingerchuk
Ingested Type I Interferon in Experimental Autoimmune Encephalomyelitis	163	(40)
Staley A. Brod
Neuromyelitis Optica	203	(14)
Dean M. Wingerchuk
Transverse Myelitis: Clinical Manifestations, Pathogenesis, and Management	217	(20)
Chitra Krishnan
Adam I. Kaplin
Deepa M. Deshpande
Carlos A. Pardo
Douglas A. Kerr
Optic Neuritis: Pathogenesis, Immunology, Diagnosis, and Clinical Management	237	(20)
Robert Zivadinov
Rohit Bakshi
Central Nervous System Vasculitis: Pathogenesis, Immunology, and Clinical Management	257	(12)
Shariq Mumtaz
Marjorie R. Fowler
Eduardo Gonzales-Toledo
Roger E. Kelley
Neurosarcoidosis: Pathogenesis, Immunology, and Clinical Management	269	(22)
Dakshinamurty Gullapalli
Lawrence H. Phillips, II
Neuropsychiatric SLE: Pathogenesis, Immunology, and Clinical Management	291	(14)
Deborah Aleman-Hoey
Robin L. Brey
Gene Expression in HIV-Associated Dementia	305	(14)
Paul Shapshak
Alireza Minagar
Elda M. Duran
Fabiana Ziegler
Wade Davis
Raman Seth
Toni Kazic
Human T-Lymphotropic Virus-Associated Neurological Disorders: Pathogenesis, Immunology, and Clinical Management	319	(18)
Michael D. Lairmore
Bindhu Michael
Lee Silverman
Amrithraj Nair
West Nile Virus Infection of the Nervous System: Pathogenesis, Immunology, and Clinical Management	337	(12)
Douglas J. Lanska
Index	349