Inflammatory Processes: Molecular Mechanisms & Therapeutic Opportunities Opportunities

by Letts, L. Gordon

• ISBN13: 9783764360252
• ISBN10: 3764360259
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-08-01
• Publisher: BIRKHAUSER BOSTON INC

Summary

In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Table of Contents

List of contributors	vii
Preface	ix
The role of eotaxin and related CC-chemokines in asthma and allergy	1	(12)
Tracey J. Mitchell
Timothy J. Williams
Signal transduction by the JNK group of MAP kinases	13	(10)
Roger J. Davis
Cellular signaling to NF-κB: Role in inflammation and therapeutic promise	23	(16)
Marie Chabot-Fletcher
Small molecule regulators of AP-1 and NF-κB	39	(14)
Anthony M. Manning
Mammalian target of rapamycin: immunosuppressive drugs offer new insights into cell growth regulation	53	(14)
Robert T. Abraham
Constitutive expression of a tumor suppressor leads to tumor regression in a xenograft model	67	(10)
Catherine Adams Burton
John Boylan
Candy Robinson
Janet Kerr
Pamela Benfield
Macrophage metalloproteinases in destructive inflammatory diseases	77	(6)
Steven D. Shapiro
Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme	83	(6)
Nancy H. Ruddle
Chemokine/cytokine biology during the evolution of fibrotic disease	89	(10)
Steven L. Kunkel
Sem H. Phan
Nicholas W. Lukacs
Cory Hogaboam
Stephen W. Chensue
The role of MCP-1 in disease	99	(10)
Long Gu
Susan C. Tseng
Barrett J. Rollins
The role of chemokines in allergic diseases of the airways	109	(12)
Lisa A. Beck
Cristiana Stellato
Syed Shahabuddin
Renate Nickel
Robert P. Schleimer
Ninth International Conference of the Inflamation Research Association, November 1-5, 1998: Summaries of workshops and poster discussions
James Winkler
Ken Tramposch
Targets in rheumatoid and osteoarthritis	121	(4)
William Williams
Elizabeth Arner
Signal transduction and regulation of gene expression	125	(4)
Lawrence Wennogle
Nancy Cusack
Mediators of inflammation and their enzymes	129	(2)
James Burke
Floyd Chilton
Cell adhesion molecules and leukocyte trafficking	131	(4)
Denis Schrier
Fandrew Issekutz
Pulmonary inflammation, fibrosis, and disease	135	(4)
Robert M. Strieter
David Underwood
Angiogenesis, wound repair and skin inflammation	139	(2)
W. Hunter
E. Turley
Index	141