Inhibin, Activin and Follistatin in Human Reproductive Physiology

by Muttukrishna, Shanti

• ISBN13: 9781860942051
• ISBN10: 1860942059
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-08-01
• Publisher: IMPERIAL COLLEGE PRESS

Summary

An understanding of the participation of inhibin and activin in the regulation of the ovary and testis has provided illuminating insights into the physiology and pathology of human gonadal function. Rapid progress has been made in both reproductive physiology and possible applications in clinical practice. In addition, the discovery that both inhibin and activin are placental hormones with altered secretion in disease states, such as pre-eclampsia, has proven to be one of the most exciting aspects of work in this area of human biology.

This book comprehensively reviews the current state of knowledge in this field, and identifies areas for future work in both clinical and basic research.

Table of Contents

Foreword	v
Introduction	1	(10)
S. Muttukrishna
P.G. Knight
Development of Immunoassays for Inhibin, Activin and Follistatin	11	(50)
L.W. Evans
N.P. Groome
Endocrine, Autocrine and Paracrine Actions of Inhibin, Activin and Follistatin on Follicle-Stimulating Hormone	61	(30)
V. Padmanabhan
C. West
Regulation of Production and Intraovarian Roles of Inhibin, Activin and Follistatin	91	(28)
P.G. Knight
C. Glister
Inhibin, Activin and Follistation in Human Pregnancy	119	(22)
S. Muttukrishna
Follistatin: From Puberty to Menopause	141	(24)
D.J. Phillips
D.M. de Kretser
V. Padmanabhan
Inhibin and Activin in the Male	165	(18)
W. Ledger
Measurement of Inhibin and Activin: A Diagnostic Tool in Female Reproductive Endocrinology?	183	(40)
G. Lockwood
Clinical Utility of Inhibin/Activin Subunits in the Immunopathology of Gonadal Tissue	223	(16)
S. Manek
Activin Receptors and Their Mechanism of Action	239	(40)
C.M. Zimmerman
L.S. Mathews
Transgenic Mouse Models to Study Inhibin and Activin	279	(50)
T.M. Pierson
M.M. Matzuk
Index	329