Inhibitors in Patients with Haemophilia

by Editor: E. C. Rodriquez-Merchan; Editor: Christine A. Lee (Professor of Haemophilia, Director and Consultant haematologist, Haemophilia Centre and Haemostasis Unit, The Royal Free Hospital, London, UK)

• ISBN13: 9780470757246
• ISBN10: 0470757248
• Format: eBook
• Copyright: 2008-06-01
• Publisher: Wiley-Blackwell

Summary

Edited by an orthopaedic surgeon and a haematologist who are leading specialists in the treatment of haemophilia, Inhibitors in Patients with Haemophilia reviews the different haemostatic products and protocols for the control of bleeding and surgery in haemophilic patients with inhibitors. The book draws together in a single volume all of the clinical issues involved in the treatment of inhibitors from numerous specialists worldwide. It will be an invaluable resource for all those treating inhibitors in people with haemophilia.

Table of Contents

Contributors

Preface

Haematology

Natural history of inhibitor in severe haemophilia A and B: incidence and prevalence

Jeanne Lusher (USA)

Characterisation of inhibitors in congenital haemophilia

Kathelijne Peerlinck and Marc Jacquemin (Belgium)

Incidence and prevalence of inhibitors and type of blood product in haemophilia A

Christine Lee and Thynn Thynn Yee (UK)

Genetic basis of inhibitor development in severe haemophilia A and B

Edward Tuddenham (UK) and Johannes Oldenburg (Germany)

Management Of Treatment

Therapeutic products: human FVIII, porcine FVIII, prothrombin complex concentrates, activated prothrombin complex concentrates and recombinant FVIIa

Thierry Lambert (France)

Methods: plasmapheresis and protein A immuno-adsorption

Eric Berntorp (Sweden)

Venous access in children with inhibitors

Rolf Ljund (Sweden)

Immunetolerance

Immunetolerance: high dose regimen

Hans Brackmann and Thomas Wallny (Germany) (To be agreed)

Immunetolerance: low dose regimen

Eveline Mauser-Bunschotten (Netherlands)

Immunotolerance and choice of concentrates

Wolfgang Kreutz (Germany)

Immunetolerance regimen: the North America registry (To be agreed)

Donna DiMichele (USA)

Medical Management Of Bleeding Episodes

Treatment of bleeding episodes in children

Joan Tusell (Spain)

General medical management of bleeding episodes: haemarthroses, muscle haematoma, mucocutaneous bleed, haematuria

Manuel Quintana (Spain)

Life- and limb-threatening bleeding episodes and intracranial bleeds

Sam Schulman (Sweden)

Inhibitors In Haemophilia B

Inhibitors in haemophilia B patients

India Warrier (USA)

Inhibitors in mild/moderate haemophilia

Charles Hay (UK)

Acquired inhibitors to FVIII

Craig Kessler (USA)

Musculoskeletal Issues

Pathogenesis of musculoskeletal complications of haemophilia

E C Rodriguez-Merchan (Spain)

Orthopaedic management of haemarthroses

E C Rodriguez-Merchan (Spain)

Synoviorthesis with Rifampicin

Horacio Caviglia (Argentina) and F Fernandez-Palazzi (Venezuela)

Radiosynoviorthesis

Eric Berntorp (Sweden)

Musculoskeletal MRI

Rachel Nuss and Jerome Wiedel (USA)

Iliopsoas haematomas and limb compartment syndromes

Michael Heim (Israel)

Pseudotumours

Marvin Gilbert (USA)

Haemophilia patients with inhibitors: a rheumatologist´s point of view

John York (Australia)

Rehabilitation

Felipe Querol and José Aznar (Spain)

Physiotherapy

Karen Beeton (UK)

Elective orthopaedic surgery in patients with high responding inhibitors-

Ivan Hvid, J Soballe and J Ingerslev (Denmark)

General Surgery

General and emergency surgery in patients with high responding inhibitors

Owen Smith & Barry White (Ireland)

Dental extractions

Uri Martinowitz (Israel)

Psychosocial Issues

Psychological issues

Pilar Arranz (Spain)

General Strategy For Management Of Inhibitor Patients

Inga Scharrer (Germany)

Index

Table of Contents provided by Publisher. All Rights Reserved.