For James D. Watson, the year 2003 was momentous: The 50th anniversary of the discovery, with Francis Crick, of the DNA double helix; the 35th anniversary of the publication of his best#x13;selling memoir of the discovery, The Double Helix;the 35th anniversary of his appointment as Director of Cold Spring Harbor Laboratory, an institution he molded into a research and education center of international renown and prestige: and the year in which the sequencing of the human genome was completed, a project of unprecedented international effort and coordination that Watson got off the ground and sustained during its first, critical years. In the course of his 75 years, Watson has achieved a reputation as outspoken, capricious, abrasive, and ruthless in pursuing his visionary goals. Few other scientists have achieved his celebrity status, or enjoyed it so much, without losing professional credibility. Yet behind the public notoriety there is a complexity apparent only to those who know Watson as a colleague, mentor, inspiration, and friend. This book gives voice to 43 of these individuals#x14;people of distinction who have worked with Watson as a scientist, educator, author, administrator, and government official. Their essays cover much of his scientific life and, taken together, create a portrait of a complex man whose originality and force of will have produced extraordinary achievements.

Preface,

xi

Acknowledgments,

xiii

Foreword,

xv

by Matt Ridley

James D. Watson's Life and Work: A Timeline,

xxi

SECTION I ORIGINS,

1

(42)

INTRODUCTION: STUDENT DAYS,

3

(40)

Phage Days in Indiana,

5

(4)

Renato Dulbecco

Quiz Kids,

9

(6)

Gunther S. Stent

Some Early Recollections of Jim Watson,

15

(4)

Seymour Benzer

REPRINT: The Properties of X-ray-inactivated Bacteriophage. I. Inactivation by Direct Effect,

19

(26)

James Dewey Watson

SECTION II CAMBRIDGE,

43

(64)

INTRODUCTION: TALKING AND THINKING,

45

(64)

Jim's Cool Reception among the British Geneticists,

49

(6)

Avrion Mitchison

Recollections of Jim Watson,

55

(2)

Naomi Mitchison

Our Work on Virus Structure,

57

(8)

Francis H.C. Crick

One Day in the Cavendish (April 1, 1953),

65

(2)

Gerald Roland Pomerat

Jim and Syd,

67

(4)

Sydney Brenner

A Letter to Jim, January 14, 2002,

71

(4)

Max F. Perutz

Monday Morning Quarterback,

75

(2)

Elof Carlson

"The Night before Crickmas,"

77

(2)

Rollin Hotchkiss

REPRINT: A Structure for Deoxyribose Nucleic Acid,

79

(4)

J.D. Watson and F.H.C. Crick

REPRINT: Genetical Implications of the Structure of Deoxyribonucleic Acid,

83

(4)

J.D. Watson and F.H.C. Crick

REPRINT: The Complementary Structure of Deoxyribonucleic Acid,

87

(23)

F.H.C. Crick and J.D. Watson

1953 SYMPOSIUM,

107

(2)

INTRODUCTION: A DAY IN JUNE,

109

(28)

Memories of the 1953 Symposium,

110

(6)

Robert L. Sinsheimer, Julius Marmur, Charles Yanofsky, Louis Siminovitch, Frank Fenner, Roy J. Britten, Howard Green, Theodore Truck, Waclaw Szybalski, Joseph S. Gots, Hillary Koprowski

Symposium on "Viruses,"

116

(1)

The Long-Islander Article

Letter to Max Delbrück,

117

(4)

James D. Watson

REPRINT: The Structure of DNA,

121

(12)

J.D. Watson and F.H.C. Crick

Nobel Banquet Speech,

133

(4)

James D. Watson

SECTION III CAREER SCIENTIST,

137

(88)

INTRODUCTION: CALTECH, CAMBRIDGE, AND HARVARD,

139

(4)

Remembering Delbrück,

143

(2)

James D. Watson

Does RNA Form a Double Helix?,

145

(14)

Alexander Rich

Flowers and Phage,

159

(8)

Joan Steitz

On the Edge: My Time in Jim Watson's Lab,

167

(6)

Benno Müller-Hill

When Ribosomes Were King,

173

(4)

Alfred Tissières

It Smells Right...,

177

(6)

Lionel V. Crawford

Excerpt from Naturalist,

183

(6)

Edward O. Wilson

Growing Up Around Jim,

189

(10)

Jeffrey H. Miller

Seems Simple, Very Hard to Do,

199

(4)

Mark Ptashne

Watson at Harvard (1956-1976),

203

(8)

Paul Doty

REPRINT: Structure of Small Viruses,

211

(6)

F.H.C. Crick and J.D. Watson

REPRINT: Unstable Ribonucleic Acid Revealed by Pulse Labelling of Escherichia coli,

217

(8)

F. Gros, H. Hiatt, W. Gilbert, C.G. Kurland, R.W. Risebrough, and J.D. Watson

SECTION IV COLD SPRING HARBOR,

225

(138)

INTRODUCTION: AN EMOTIONAL ATTACHMENT,

227

(4)

Cold Spring Harbor 1958-1968: The Years between Demerec and Watson,

231

(12)

John Cairns

Life with Jim,

243

(14)

Norton D. Zinder

CSHL in the Sixties: A View from the Trenches,

257

(6)

Ann Skalka

REPRINT: Cold Spring Harbor Laboratory Director's Report, 1989,

263

(10)

James D. Watson

Jim as a Mentor, 1971-1974,

273

(4)

Phillip A. Sharp

From Development of Yeast Cells to Human Brain Hemispheres,

277

(8)

Amar J.S. Klar

Big Shoes to Fill, with the Laces Untied,

285

(8)

Bruce Stillman

Just Jim,

293

(8)

Michael Wigler

Milestones and Mentoring: How Jim Watson Influenced a Scientific Career,

301

(14)

Douglas Hanahan

CSHL in Transition,

315

(6)

Raymond F. Gesteland

Cold Spring Harbor and Recombinant DNA,

321

(8)

Thomas Maniatis

REPRINT: Origin of Concatemeric T7 DNA,

329

(8)

J.D. Watson

Jim and the Board: Behind the Scenes,

337

(8)

Bayard Clarkson

Vision, Innovation, Breadth, and Strength,

345

(4)

David L. Luke III

Portraits: Robertson, Pulling, and Grace,

349

(4)

James D. Watson

A Morning on the Porch,

353

(4)

Jim Eisenman

An Architect at the Lab: Some Personal Recollections,

357

(6)

William Grover

SECTION V GENOMES,

363

(50)

INTRODUCTION: MANAGING THE GENOME,

365

(4)

Dr. Watson Goes to Washington,

369

(8)

Bradie Metheny

Jim Watson and the Human Genome Project,

377

(10)

James B. Wyngaarden

The Colossus of Codes,

387

(8)

Robert Gook-Deegan

Jim and the Japanese Human Genome Project,

395

(8)

Kenichi Matsubara

Climbing the Ladder of Life: James D. Watson and the ELSI Years,

403

(10)

Nancy Wexler

SECTION VI EDUCATION,

413

(42)

INTRODUCTION: COMMUNICATING SCIENCE,

415

(2)

The Pied Piper at Harvard,

417

(6)

David Botstein

There Is More Yet to Come,

423

(6)

Arnold J. Levine

What I Have Learned from Jim,

429

(6)

Bruce M. Alberts

On Drawing Molecules,

435

(8)

Keith Roberts

Education by the Sea Shore,

443

(12)

Jan Witkowski and John Inglis

Endnotes,

455

(22)

Bibliography-James D. Watson,

477

(6)

Index,

483

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Inspiring Science: Jim Watson and the Age of DNA

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