Insulin Resistance and Nonalcoholic Fatty Liver Disease (Nafld) / Nonalcoholic Steatohepatitis (Nash)

by Yoneda, Masato

• ISBN13: 9781616689278
• ISBN10: 1616689277
• Edition: 1st
• Format: Paperback
• Copyright: 2010-10-01
• Publisher: Nova Science Pub Inc

Summary

The liver is the first organ to receive nutrients that enter the body via the intestines after a meal, and this organ plays a pivotal role in energy metabolism. Non-alcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the world and is now considered to be a component of metabolic syndrome. A wide spectrum of histological changes has been observed in NAFLD, ranging from simple steatosis, which is generally non-progressive, to nonalcoholic steatohepatitis (NASH), liver cirrhosis, liver failure, and sometimes even hepatocellular carcinoma. This book reviews recent evidence concerning insulin resistance and NAFLD/NASH as a step towards a comprehensive understanding of the pathophysiology and treatment of NAFLD/NASH.

Table of Contents

Introduction

NAFLD & Insulin Resistance (IR)

Pathophysiology of NASH: Insulin Resistance, Free Fatty Acids & Cytokines

Adiponectin & NASH

TNF-a & NAFLD/NASH a

Leptin & NAFLD/NASH

Peroxisome Proliferators-Activated Receptors (PPARs) & NAFLD/NASH

Iron Overload & NAFLD/NASH

Mitochondrial Abnormalities & NAFLD/NASH

Genetic Influences in NAFLD / NASH

Therapeutic Strategy for NASH Patients

Natural History of NAFLD

Conclusions

Index

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