Interactions of Blood and the Pulmonary Circulations

by Weir, E. Kenneth; Reeve, Helen L.; Reeves, John T.

• ISBN13: 9780879937010
• ISBN10: 0879937017
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-02-26
• Publisher: Wiley-Blackwell

Summary

A thorough exploration of the interaction between erythrocytes, leukocytes, platelets, and the pulmonary vasculature in a variety of disease states-an important topic not addressed by other books.The lungs accommodate the entire cardiac output, and the pulmonary vessels are well known for their metabolic and endocrine functions, as well as gas exchange. The interaction of the pulmonary circulation with the cellular elements of blood has received less attention. Interactions of Blood and the Pulmonary Circulation covers many topics of interest to the clinician. In particular, chapters on sickle cell anemia provide a wealth of information on mechanisms of vascular occlusion, suggesting new approaches to treatment for the cardiologist and the pulmonary and intensive care physician. Intensivists will also enjoy the chapters on the role of leukocytes and inflammation in lung injury, and those on the contribution of platelets and thrombosis in pulmonary hypertension. The long-term management of chronic thromboembolic pulmonary hypertension is covered in detail.This book will be of special interest to pulmonary and intensive care physicians, cardiologists, hematologists, and vascular biologists.

Author Biography

E. Kenneth Weir is the editor of Interactions of Blood and the Pulmonary Circulations, published by Wiley.

Helen L. Reeve is the editor of Interactions of Blood and the Pulmonary Circulations, published by Wiley.

Table of Contents

Preface	v
Contributors	vii
SECTION I. Introduction
The Development of Concepts of the Interaction of Blood and the Pulmonary Circulation	3	(18)
Deborah A. Quinn
Charles A. Hales
SECTION II. Erythrocytes
The Endothelium in Sickle Cell Disease	21	(14)
Robert P. Hebbel
Thrombin, Endothelial Gap Formation, and Erythrocyte Adhesion	35	(34)
Stephen H. Embury
Neil M. Matsui
Adhesion of Sickle Erythrocytes to Extracellular Matrix	69	(14)
Cheryl A. Hillery
Mechanisms of Monocyte Migration Following Sickle Erythrocyte Adherence to Endothelium	83	(20)
Vijay K. Kalra
Suresh Selvaraj
Cage Johnson
Inflammation Causing Adhesion of Sickle Erythrocytes to Endothelium	103	(20)
Timothy M. Wick
Phospholipid Products from Activated Polymorphonuclear Cells: Potential Role in Sickle Red Blood Cell Microvascular Occlusion	123	(10)
Johnson Hayes, Jr.
Boniface Obiako
Potential New Approaches to the Treatment of Sickle Cell Disease	133	(16)
John V. Weil
Peter A. Lane
Red Blood Cell-Derived ATP Is a Determinant of Nitric Oxide Synthesis in the Pulmonary Circulation	149	(22)
Randy S. Sprague
Mary L. Ellsworth
Alan H. Stephenson
Andrew J. Lonigro
Malaria and the Microcirculation	171	(16)
May Ho
SECTION III. Platelets
The Role of Platelets in Pulmonary Hypetension	187	(16)
Andrew J. Peacock
Paul Egermayer
G. Ian Town
Emerging Concepts of the Mechanisms of Platelet Secretion	203	(12)
Guy L. Reed
Platelet Activation: Communication with Integrin Cytoplasmic Domains	215	(12)
Leslie V. Parise
Control of Platelet Reactivity by Endothelial Ecto-ADPase/CD39: Significance for Occlusive Vascular Diseases	227	(12)
Aaron J. Marcus
M. John Broekman
Joan H.F. Drosopoulos
Naziba Islam
Richard B. Gayle
David J. Pinsky
Charles R. Maliszewski
SECTION IV. Leukocytes
Neutrophil Degranulation: Mechanisms of Regulation and Dysregulation in Interactions with Endothelial Cells	239	(16)
Tadaatsu Imaizumi
Matthew K. Topham
Thomas M. McIntyre
Stephen M. Prescott
Guy A. Zimmerman
Leukocyte Adhesion and Emigration in the Lung	255	(22)
S. Bradley Forlow
C. Edward Rose
Klaus Ley
In Vitro Regulation of Leukocyte Diapedesis by the Endothelial Cell Contractile Apparatus	277	(14)
Keri N. Jacobs
Irina Petrache
Joe G.N. Garcia
Neutrophil Sequestration and Migration in Lung Microvessels: Influence of Neutrophil Heterogeneity	291	(26)
Stephan F. van Eeden
Leukocyte and Erythrocyte Kinetics in the Pulmonary Microcirculation	317	(24)
Wiltz W. Wagner, Jr
SECTION V. Thrombosis
Coagulation and Fibrinolytic Factors in Pulmonary Hypertension	341	(22)
Carolyn H. Welsh
Molecular Approaches to Identify Mechanisms of Thrombus Stabilization in the Pulmonary Vasculature	363	(8)
Elisabeth Gharehbaghi-Schnell
Irene M. Lang
Hypoxia-Induced Activation of Early Growth Response (Egr)-1: A Novel Pathway Mediating the Vascular Response to Oxygen Deprivation	371	(12)
Shi Fang Yan
David J. Pinsky
David M. Stern
Long-Term Sequelae Following Pulmonary Thromboendarterectomy	383	(16)
William R. Auger
Index	399