Interactive and Integrative Cardiology, Volume 1080

by Sideman, Samuel; Beyar, Rafael; Landesberg, Amir

• ISBN13: 9781573316514
• ISBN10: 1573316512
• Edition: 1st
• Format: Paperback
• Copyright: 2006-12-04
• Publisher: Wiley-Blackwell

Summary

The characteristics of the basic elements and the cardiac functions will be highlighted in this volume. In their contributions, the authors concentrate on the analysis and integration of the interactions of the micro-scale cellular elements, as well as of the macro-scale phenomena and their effects on the function of the cardiovascular system.The general goals of the cardiac workshop of which this volume is the proceedings were to (1) foster interdisciplinary interaction between leading world scientists and clinical cardiologists so as to identify "black holes" and catalyze new research ideas; (2) relate basic micro-scale, molecular, and subcellular phenomena to the clinically manifested cardiac performance; (3) apply conceptual modeling and quantitative analysis to better explore, describe, and understand cardiac physiology; (4) interpret available clinical data and design new revealing experiments; and (5) enhance international cooperation in the search for the secrets of life and their implications in cardiac pathophysiology.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Samuel Sideman, Rafael Beyar, Amir Landesberg

All of the Israel Institute of Technology, Haifa, Israel

Table of Contents

Preface: The Challenge of Cardiac Modeling Interaction and Integration.
By SAMUEL SIDEMAN
Part I. Development and Genetics
Functional Studies of Individual Myosin Molecules.
By JODY A. DANTZIG, TIM Y. LIU, AND YALE E. GOLDMAN	1
Recruitment of New Cells into the Postnatal Heart: Potential Modification of Phenotype By Periostin.
By RICHARD P. VISCONTI AND ROGER R. MARKWALD	19
Cell-Based Approaches for Cardiac Repair.
By MICHAEL RUBART AND LOREN J. FIELD	34
The Unstoppable Connexin43 Carboxyl-Terminus: New Roles in Gap Junction Organization and Wound Healing.
By ROBERT G. GOURDIE, GAUTAM S. GHATNEKAR, MICHAEL O'QUINN, MATTHEW J. RHETT, RALPH J. BARKER, CHING ZHU, JANE JOURDAN, AND ANDREW W. HUNTER	49
The Developing Cardiac Myocyte: Maturation of Excitability and Excitation–Contraction Coupling.
By ELIZABETH A. SCHRODER, YIDONG WEI, AND JONATHAN SATIN	63
Dynamic Interactions between Myocytes, Fibroblasts, and Extracellular Matrix.
By INDRONEAL BANERJEE, KRISHNA YEKKALA, THOMAS K. BORG, AND TROY A. BAUDINO	76
Embryonic Heart Induction.
By ANN C. FOLEY, RUCHIKA W. GUPTA, ROSA M. GUZZO, OKSANA KOROL, AND MARK MERCOLA	85
The Role of Basic Leucine Zipper Protein-Mediated Transcription in Physiological and Pathological Myocardial Hypertrophy.
By IZHAK KEHAT, TAL HASIN, AND AMI ARONHEIM	97
Part II. Mechanochemical Interactions Hypertrophy and Atrophy of the Heart: The Other Side of Remodeling.
By PETER RAZEGHI AND HEINRICH TAEGTMEYER	110
Role of Cellular Compartmentation in the Metabolic Response to Stress: Mechanistic Insights from Computational Models.
By LUFANG ZHOU, XIN YU, MARCO E. CABRERA, AND WILLIAM C. STANLEY	120
Maintenance of the Metabolic Homeostasis of the Heart: Developing a Systems Analysis Approach.
By ROBERT S. BALABAN	140
Part III. Electrochemical Interactions
Diversity of Ca²+ Signaling in Developing Cardiac Cells.
By EINSLEY JANOWSKI, LARS CLEEMANN, PHILIPP SASSE, AND MARTIN MORAD	154
Regulation of Ca²+ and Nat in Normal and Failing Cardiac Myocytes.
By DONALD M. BERS, SANDA DESPA, AND JULIE BOSSUYT	165
The Integration of Spontaneous Intracellular Ca²+ Cycling and Surface Membrane Ion Channel Activation Entrains Normal Automaticity in Cells of the Heart's Pacemaker.
By EDWARD G. LAKATTA, TATIANA VINOGRADOVA, ALEXEY LYASHKOV, SYEVDA SIRENKO, WEIZONG ZHU, ABDUL RUKNUDIN, AND VICTOR MALTSEV	178
Calcium Handling in Embryonic Stem Cell–Derived Cardiac Myocytes: Of Mice and Men.
By ILANIT ITZHAKI, JACKIE SCHILLER, RAFAEL BEYAR, JONATHAN SATIN, AND LIOR GEPSTEIN	207
Cellular Alternans: A Mechanism Linking Calcium Cycling Proteins to Cardiac Arrhythmogenesis.
By LANCE D. WILSON, XIAOPING WAN, AND DAVID S. ROSENBAUM	216
Part IV. Electromechanical Interactions
The Mechanoelectric Feedback: A Novel "Calcium Clamp" Method, using Tetanic Contraction, for Testing the Role of the Intracellular Free Calcium.
By YAEL YANIV, CARMIT LEVY, AND AMIR LANDESBERG	235
Role of Sarcomere Mechanics and Ca²+ Overload in Ca²+ Waves and Arrhythmias in Rat Cardiac Muscle.
By HENK E.D.J. TER KEURS, YUJI WAKAYAMA, YOSHINAO SUGAI, GUY PRICE, YUTAKA KAGAYA, PENELOPE A. BOYDEN, MASAHITO MIURA, AND BRUNO D.M. STUYVERS	248
Cellular Basis for the Repolarization Waves of the ECG.
By CHARLES ANTZELEVITCH	268
Mcchanosensitive-Mediated Interaction, Integration, and Cardiac Control.
By MAX J. LAB	282
Three-Dimensional Models of Individual Cardiac Histoanatomy: Tools and Challenges.
By REBECCA A.B. BURTON, GERNOT PLANK, JÜRGEN E. SCHNEIDER, VICENTE GRAU, HELMUT AHAMMER, STEPHEN L. KEELING, JACK LEE, NICOLAS P. SMITH, DAVID GAVAGHAN, NATALIA TRAYANOVA, AND PETER KOHL	301
Cardiac Defibrillation and the Role of Mechanoelectric Feedback in Postshock Arrhythmogenesis.
By VIATCHESLAV GUREV, MARY M. MALECKAR, AND NATALIA A. TRAYANOVA	320
Part V. Integrated Models and Analysis Modeling Cardiac Electrical Activity at the Cell and Tissue Levels.
By TRAVIS M. AUSTIN, DARREN A. HOOKS, PETER J. HUNTER, DAVID P. NICKERSON, ANDREW J. PULLAN, GREGORY B. SANDS, BRUCE H. SMAILL, AND MARK L. TREW	334
Cardiac β-Adrenergic Signaling: From Subcellular Microdomains to Heart Failure.
By JEFFREY J. SAUCERMAN AND ANDREW D. MCCULLOCH	348
Multiscale Modeling of Calcium Signaling in the Cardiac Dyad.
By RAIMOND L. WINSLOW, ANTTI TANSKANEN, MINDAO CHEN, AND JOSEPH L. GREENSTEIN	362
Nonlinear Dynamics of Paced Cardiac Cells.
By YOHANNES SHIFERAW, ZHILIN QU, ALAN GARFINKEL, ALAIN KARMA, AND JAMES N. WEISS	376
Modeling Cardiac Ischemia.
By BLANCA RODRIGUEZ, NATALIA TRAYANOVA, AND DENIS NOBLE	395
Part VI. Novel Therapeutics Cardiovascular Therapeutic Aspects of Cell Therapy and Stem Cells.
By LIOR GEPSTEIN	415
Adenylyl Cyclase Gene Transfer in Heart Failure.
By H. KIRK HAMMOND	426
Genetic Engineering and Therapy for Inherited and Acquired Cardiomyopathies.
By SHARLENE DAY, JENNIFER DAVIS, MARGARET WESTFALL, AND JOSEPH METZGER	437
Nanomedicine Opportunities in Cardiology.
By GREGORY LANZA, PATRICK WINTER, TILLMANN CYRUS, SHELTON CARUTHERS, JON MARSH, MICHAEL HUGHES, AND SAMUEL WICKLINE	451
Effects of Synchronized Cardiac Assist Device on Cardiac Energetics.
By AMIR LANDESBERG, AVSHALOM SHENHAV, RONA SHOFTY, EUGENE KONYUKHOV, CARMIT LEVY, OSCAR LICHTENSTEIN, RAFAEL BEYAR, HENK EDJ TER KEURS, GIORA LANDESBERG, MARCO CABRERA, WILLIAM STANLEY, AND GERALD M. SAIDEL	466
Index of Contributors	479