International Review of Cell and Molecular Biology

by Jeon

• ISBN13: 9780123748065
• ISBN10: 0123748062
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-06-19
• Publisher: Elsevier Science

Summary

International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. * Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists

Table of Contents

Contributors	p. vii
Cell and Molecular Biology of Invadopodia	p. 1
Introduction	p. 2
Biogenesis, Molecular Components, and Activity	p. 3
Open Questions and Concluding Remarks	p. 23
References	p. 25
Viral Channel-Forming Proteins	p. 35
Introduction	p. 36
Channel-Forming Proteins	p. 37
Detecting a Channel-Forming Protein	p. 44
Functional and Structural Characterization	p. 47
Channel-Forming Proteins in Antiviral Therapy	p. 51
Concluding Remarks	p. 53
References	p. 54
Notch Signaling in Chondrogenesis	p. 65
Introduction	p. 66
Helix-Loop-Helix Proteins	p. 66
Notch Genes	p. 69
Notch1 as a Marker for Progenitor Cells in Adult Cartilage	p. 72
Function of Notch Signaling During Chondrogenesis	p. 74
Notch Signaling in Osteoarthritis	p. 79
Concluding Remarks	p. 82
References	p. 83
The Controversial Role of Mast Cells in Tumor Growth	p. 89
Introduction	p. 90
Biological Functions of Mast Cells	p. 91
Mast Cell Development, Anatomical Distribution, and Phenotype	p. 98
Mast Cell-Derived Secretory Products	p. 102
Mast Cells in Experimental Carcinogenesis	p. 106
Mast Cells and Tumor Growth in Humans: Pro and Contra	p. 107
Mast Cells and Tumor Angiogenesis and Lymphangiogenesis	p. 111
Concluding Remarks	p. 118
References	p. 119
Limbal Stem Cells: Application in Ocular Biomedicine	p. 133
Introduction	p. 134
Ocular Surface and Limbal Stem Cells	p. 135
Conventional Treatment Modalities of Limbal Stem Cell Deficiency	p. 140
Concept of Cultivated Limbal Stem Cell Transplantation	p. 144
Review of Literature on Clinical Trials	p. 167
Concluding Remarks	p. 171
References	p. 172
Cell and Molecular Biology of the Novel Protein Tyrosine-Phosphatase-Interacting Protein 51	p. 183
Introduction	p. 184
Molecular Biology of PTPIP51	p. 184
Signaling Partners of PTPIP51	p. 193
Expression Profile of PTPIP51	p. 208
Conclusions and Further Perspective	p. 226
References	p. 227
Index	p. 247
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