Intraoperative Irradiation

by Gunderson, Leonard L.; Willett, C. g; Calvo, F. a; Harrison, Louis B.

• ISBN13: 9781617790140
• ISBN10: 1617790141
• Edition: 2nd
• Format: Hardcover
• Copyright: 2011-04-15
• Publisher: Humana Pr Inc

Summary

The rationale for using intraoperative irradiation (IORT) is based on the realization that tolerable doses of external beam radiation are often insufficient to achieve control of locally advanced malignancies.  In these instances, the IORT component of treatment becomes the optimal conformal technique of irradiation, since dose-limiting organs or structures can either be surgically displaced or protected by placement of lead shielding. This fully revised and expanded second edition is of interest to those with intraoperative electron (IOERT) capabilities, high-does-rate brachytherapy (HDR-IORT) capabilities, or both.  Techniques, indications, and results are discussed by disease site.  Each chapter is dual authored by a radiation oncologist and a surgeon, giving a balanced presentation of clinical scenarios.  Issues of basic science and physics are also covered, and a notable chapter on normal tissue tolerance is included. Intraoperative Irradiation: Techniques and Results, Second Edition is a superb compilation, providing essential cutting-edge knowledge.  It is a foundation for physicians as IORT develops and becomes more widely available.

Table of Contents

General Rationale and Historical Perspective
Rationale and Historical Perspective of Intraoperative Irradiation	p. 3
Biology of Large Dose per Fraction Irradiation	p. 27
Methods and Techniques of Treatment
Intraoperative Electron Beam Irradiation: Physics and Techniques	p. 51
HDR-IORT: Physics and Techniques	p. 73
Electronic Brachytherapy/Low KV-IORT: Physics and Techniques	p. 85
IORT with Electron-Beam, High-Dose-Rate Brachytherapy or Low-KV/Electronic Brachytherapy: Methodological Comparisons	p. 99
Normal Tissue Tolerance - IORT
Normal-Tissue Tolerance to IOERT, EBRT, or Both: Animal and Clinical Studies	p. 119
Results of IORT Alone or Plus EBRT by Disease Site
Central Nervous System Tumors	p. 141
Head and Neck Cancer	p. 163
Breast Cancer	p. 189
Lung Cancer	p. 201
Gastric Cancer	p. 223
Pancreas Cancer	p. 249
Bile Duct and Gallbladder Cancer	p. 273
Primary Colorectal Cancer	p. 297
Recurrent Colorectal Cancer	p. 323
Retroperitoneal Sarcomas	p. 353
Extremity and Trunk Soft-Tissue Sarcomas	p. 387
Bone Sarcomas	p. 407
Gynecologic Malignancies	p. 431
Genitourinary Cancer	p. 459
Pediatric Malignancies	p. 481
Conclusions and Future Possibilities
Conclusions and Future Possibilities: IORT	p. 503
Index	p. 519
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