Introduction to Biocatalysis Using Enzymes and Microorganisms

by S. M. Roberts , Nicholas J. Turner , Andrew J. Willetts , Michael K. Turner

• ISBN13: 9780521430708
• ISBN10: 0521430704
• Format: Hardcover
• Copyright: 1995-01-27
• Publisher: Cambridge University Press

Summary

This is an introductory text intended to give the non-specialist a comprehensive insight into the science of biotransformations. The book traces the history of biotransformations, clearly spells out the pros and cons of conducting enzyme-mediated versus whole-cell bioconversions, and gives a variety of examples wherein the bio-reaction is a key element in a reaction sequence leading from cheap starting materials to valuable end-products (such as pharmaceuticals and agrochemicals, fragrances and flavours). Biotransformations involving the hydrolysis of esters, amides and nitriles, the synthesis of esters and amides, reduction and oxidation reactions and carbon-carbon bond-forming systems are discussed. The book finishes with a discussion of some industrially important large-scale bioconversions.

Table of Contents

Preface

1. An historical introduction to biocatalysis using enzymes and microorganisms

2. The inter-relationship between enzymes and cells with particular reference to whole-cell biotransformations using bacteria and fungi

3. Useful intermediates and end-products obtained from whole-cell/enzyme catalysed hydrolysis and esterification reactions

4. Useful intermediates and end-products obtained from biocatalysed oxidation and reduction reactions

5. Useful intermediates and end-products obtained from biocatalysed carbon-carbon, carbon-oxygen, carbon-nitrogen, and carbon-chalcogen bond-forming reactions

6. The application of biocatalysis to the manufacture of fine chemicals

Index.