Introduction to Biomedical Engineering

by Enderle; Bronzino; Blanchard

• ISBN13: 9780122386626
• ISBN10: 0122386620
• Edition: 2nd
• Format: Hardcover
• Copyright: 2005-04-06
• Publisher: Elsevier Science

Summary

Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field. Introduction to Biomedical Engineering, Second Edition provides a historical perspective of the major developments in the biomedical field. Also contained within are the fundamental principles underlying biomedical engineering design, analysis, and modeling procedures. The numerous examples, drill problems and exercises are used to reinforce concepts and develop problem-solving skills making this book an invaluable tool for all biomedical students and engineers. New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics.

Table of Contents

Preface	xiii
Contributors to the First Edition	xv
Contributors to the Second Edition	xix
Biomedical Engineering: A Historical Perspective	1	(30)
Evolution of the Modern Health Care System	2	(8)
The Modern Health Care System	10	(7)
What Is Biomedical Engineering?	17	(6)
Roles Played by Biomedical Engineers	23	(1)
Professional Status of Biomedical Engineering	24	(2)
Professional Societies	26	(5)
Exercises	28	(1)
References and Suggested Reading	29	(2)
Moral and Ethical Issues	31	(42)
Morality and Ethics: A Definition of Terms	33	(7)
Two Moral Norms: Beneficence and Nonmaleficence	40	(1)
Redefining Death	41	(4)
The Terminally Ill Patient and Euthanasia	45	(4)
Taking Control	49	(1)
Human Experimentation	49	(2)
Definition and Purpose of Experimentation	51	(2)
Informed Consent	53	(6)
Regulation of Medical Device Innovation	59	(2)
Marketing Medical Devices	61	(2)
Ethical Issues in Feasibility Studies	63	(2)
Ethical Issues in Emergency Use	65	(3)
Ethical Issues in Treatment Use	68	(1)
The Role of the Biomedical Engineer in the FDA Process	69	(4)
Exercises	70	(1)
Suggested Reading	71	(2)
Anatomy and Physiology	73	(54)
Introduction	74	(2)
Cellular Organization	76	(16)
Tissues	92	(2)
Major Organ Systems	94	(25)
Homeostasis	119	(8)
Exercises	121	(4)
Suggested Reading	125	(2)
Biomechanics	127	(84)
Introduction	128	(3)
Basic Mechanics	131	(20)
Mechanics of Materials	151	(8)
Viscoelastic Properties	159	(4)
Cartilage, Ligament, Tendon, and Muscle	163	(6)
Clinical Gait Analysis	169	(17)
Cardiovascular Dynamics	186	(25)
Exercises	207	(2)
Suggested Reading	209	(2)
Rehabilitation Engineering and Assistive Technology	211	(44)
Introduction	212	(6)
The Human Component	218	(6)
Principles of Assistive Technology Assessment	224	(3)
Principles of Rehabilitation Engineering	227	(12)
Practice of Rehabilitation Engineering and Assistive Technology	239	(16)
Exercises	243	(9)
Suggested Reading	252	(3)
Biomaterials	255	(58)
Materials in Medicine: From Prosthetics to Regeneration	256	(2)
Biomaterials: Properties, Types, and Applications	258	(18)
Lessons from Nature on Biomaterial Design and Selection	276	(5)
Tissue-Biomaterial Interactions	281	(9)
Guiding Tissue Repair with Bio-Inspired Biomaterials	290	(6)
Safety Testing and Regulation of Biomaterials	296	(5)
Application-Specific Strategies for the Design and Selection of Biomaterials	301	(12)
Exercises	310	(1)
Suggested Reading	311	(2)
Tissue Engineering	313	(90)
What Is Tissue Engineering?	314	(17)
Biological Considerations	331	(29)
Physical Considerations	360	(22)
Scaling Up	382	(4)
Implementation of Tissue Engineered Products	386	(4)
Future Directions: Functional Tissue Engineering and the ``-Omics'' Sciences	390	(3)
Conclusions	393	(1)
Glossary	393	(10)
Exercises	395	(5)
Suggested Reading	400	(3)
Bioinstrumentation	403	(102)
Introduction	404	(3)
Basic Bioinstrumentation System	407	(1)
Charge, Current, Voltage, Power, and Energy	408	(7)
Resistance	415	(10)
Linear Network Analysis	425	(7)
Linearity and Superposition	432	(4)
Thevenin's Theorem	436	(3)
Inductors	439	(3)
Capacitors	442	(4)
A General Approach to Solving Circuits Involving Resistors, Capacitors, and Inductors	446	(9)
Operational Amplifiers	455	(13)
Time-Varying Signals	468	(6)
Active Analog Filters	474	(10)
Bioinstrumentation Design	484	(21)
Exercises	487	(17)
Suggested Reading	504	(1)
Biomedical Sensors	505	(44)
Introduction	506	(2)
Biopotential Measurements	508	(5)
Physical Measurements	513	(14)
Blood Gases and pH Sensors	527	(9)
Bioanalytical Sensors	536	(3)
Optical Biosensors	539	(10)
Exercises	545	(3)
Suggested Reading	548	(1)
Biosignal Processing	549	(78)
Introduction	550	(1)
Physiological Origins of Biosignals	551	(3)
Characteristics of Biosignals	554	(3)
Signal Acquisition	557	(5)
Frequency Domain Representation of Biological Signals	562	(22)
Linear Systems	584	(13)
Signal Averaging	597	(8)
Wavelet Transform and Short-Time Fourier Transform	605	(7)
Artificial Intelligence Techniques	612	(15)
Exercises	619	(5)
Suggested Reading	624	(3)
Bioelectric Phenomena	627	(66)
Introduction	628	(1)
History	629	(8)
Neurons	637	(5)
Basic Biophysics Tools and Relationships	642	(11)
Equivalent Circuit Model for the Cell Membrane	653	(11)
Hodgkin-Huxley Model of the Action Potential	664	(16)
Model of the Whole Neuron	680	(13)
Exercises	684	(6)
Suggested Reading	690	(3)
Physiological Modeling	693	(106)
Introduction	694	(4)
Compartmental Modeling	698	(25)
An Overview of the Fast Eye Movement System	723	(5)
Westheimer Saccadic Eye Movement Model	728	(7)
The Saccade Controller	735	(3)
Development of an Oculomotor Muscle Model	738	(13)
A Linear Muscle Model	751	(6)
A Linear Homeomorphic Saccadic Eye Movement Model	757	(6)
A Truer Linear Homeomorphic Saccadic Eye Movement Model	763	(10)
System Identification	773	(26)
Exercises	788	(9)
Suggested Reading	797	(2)
Genomics and Bioinformatics	799	(34)
Introduction	800	(4)
Core Laboratory Technologies	804	(8)
Core Bioinformatics Technologies	812	(16)
Conclusion	828	(5)
Exercises	829	(1)
Suggested Reading	830	(3)
Computational Cell Biology and Complexity	833	(24)
Computational Biology	834	(1)
The Modeling Process	835	(11)
Bionetworks	846	(3)
Introduction to Complexity Theory	849	(8)
Exercises	852	(2)
Suggested Readings	854	(3)
Radiation Imaging	857	(48)
Introduction	858	(1)
Emission Imaging Systems	859	(17)
Instrumentation and Imaging Devices	876	(6)
Radiographic Imaging Systems	882	(23)
Exercises	902	(2)
Suggested Reading	904	(1)
Medical Imaging	905	(72)
Introduction	906	(2)
Diagnostic Ultrasound Imaging	908	(32)
Magnetic Resonance Imaging (MRI)	940	(29)
Comparison of Imaging Modes	969	(8)
Exercises	972	(3)
Suggested Reading	975	(2)
Biomedical Optics and Lasers	977	(68)
Introduction to Essential Optical Principles	979	(6)
Fundamentals of Light Propagation in Biological Tissue	985	(12)
Physical Interaction of Light and Physical Sensing	997	(9)
Biochemical Measurement Techniques Using Light	1006	(9)
Fundamentals of Photothermal Therapeutic Effects of Lasers	1015	(11)
Fiber Optics and Waveguides in Medicine	1026	(7)
Biomedical Optical Imaging	1033	(12)
Exercises	1039	(3)
Suggested Reading	1042	(3)
Appendix	1045	(40)
Index	1085