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Preface | p. xi |
Notation | p. xiii |
Introduction | p. 1 |
Examples of types of data | p. 2 |
Motivating examples | p. 3 |
A first view on the models | p. 5 |
The likelihood principle | p. 9 |
Introduction | p. 9 |
Point estimation theory | p. 10 |
The likelihood function | p. 14 |
The score function | p. 17 |
The information matrix | p. 18 |
Alternative parameterizations of the likelihood | p. 20 |
The maximum likelihood estimate (MLE) | p. 21 |
Distribution of the ML estimator | p. 22 |
Generalized loss-function and deviance | p. 23 |
Quadratic approximation of the log-likelihood | p. 23 |
Likelihood ratio tests | p. 25 |
Successive testing in hypothesis chains | p. 27 |
Dealing with nuisance parameters | p. 33 |
Problems | p. 38 |
General linear models | p. 41 |
Introduction | p. 41 |
The multivariate normal distribution | p. 42 |
General linear models | p. 44 |
Estimation of parameters | p. 48 |
Likelihood ratio tests | p. 53 |
Tests for model reduction | p. 58 |
Collinearity | p. 64 |
Inference on parameters in parameterized models | p. 70 |
Model diagnostics: residuals and influence | p. 73 |
Analysis of residuals | p. 77 |
Representation of linear models | p. 78 |
General linear models in R | p. 81 |
Problems | p. 83 |
Generalized linear models | p. 87 |
Types of response variables | p. 89 |
Exponential families of distributions | p. 90 |
Generalized linear models | p. 99 |
Maximum likelihood estimation | p. 102 |
Likelihood ratio tests | p. 111 |
Test for model reduction | p. 115 |
Inference on individual parameters | p. 116 |
Examples | p. 117 |
Generalized linear models in R | p. 152 |
Problems | p. 153 |
Mixed effects models | p. 157 |
Gaussian mixed effects model | p. 159 |
One-way random effects model | p. 160 |
More examples of hierarchical variation | p. 174 |
General linear mixed effects models | p. 179 |
Bayesian interpretations | p. 185 |
Posterior distributions | p. 191 |
Random effects for multivariate measurements | p. 192 |
Hierarchical models in metrology | p. 197 |
General mixed effects models | p. 199 |
Laplace approximation | p. 201 |
Mixed effects models in R | p. 218 |
Problems | p. 219 |
Hierarchical models | p. 225 |
Introduction, approaches to modeling of overdispersion | p. 225 |
Hierarchical Poisson Gamma model | p. 226 |
Conjugate prior distributions | p. 233 |
Examples of one-way random effects models | p. 237 |
Hierarchical generalized linear models | p. 242 |
Problems | p. 243 |
Real life inspired problems | p. 245 |
Dioxin emission | p. 246 |
Depreciation of used cars | p. 249 |
Young fish in the North Sea | p. 250 |
Traffic accidents | p. 251 |
Mortality of snails | p. 252 |
Supplement on the law of error propagation | p. 255 |
Function of one random variable | p. 255 |
Function of several random variables | p. 255 |
Some probability distributions | p. 257 |
The binomial distribution model | p. 259 |
The Poisson distribution model | p. 262 |
The negative binomial distribution model | p. 264 |
The exponential distribution model | p. 266 |
The gamma distribution model | p. 268 |
The inverse Gaussian distribution model | p. 275 |
Distributions derived from the normal distribution | p. 280 |
The Gamma-function | p. 284 |
List of symbols | p. 285 |
Bibliography | p. 287 |
Index | p. 293 |
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