Introduction to Genomics

by Lesk, Arthur

• ISBN13: 9780199296958
• ISBN10: 0199296952
• Edition: 1st
• Format: Paperback
• Copyright: 2007-03-30
• Publisher: Oxford University Press

Summary

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on andoff in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How we determine their function? And how do different genes form the regulatory networks that direct the process of life? Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health andwellbeing. Covering the latest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, the organism, the ecosystem and the biosphere. Learning features throughout make this book the ideal teachingand learning tool: extensive end of chapter exercises and problems help the student to grasp fully the concepts being presented, while end of chapter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner. The field of genomics is enabling us to analyze life in more detail than ever before; Introduction to Genomics is the perfect guide to this enthralling subject. Online Resource Centre: - Figures from the book available to download, to facilitate lecture preparation - Answers to odd-numbered end of chapter exercises, and hints for solving end of chapter problems, to support self-directed learning - Library of web links, for rapid access to a wider pool of additional resources

Author Biography

Arthur Lesk is Professor of Biochemistry and Molecular Biology at The Pennsylvania State University, USA.

Table of Contents

Introduction to genomics	p. 3
Comparative genomics	p. 71
Evolution and genomic change	p. 135
Mapping, sequencing, annotation, and databases	p. 202
Microarrays	p. 265
Proteomics	p. 305
Systems biology	p. 359
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