An Introduction to Medicinal Chemistry

by Patrick, Graham L.

• ISBN13: 9780198505334
• ISBN10: 0198505337
• Edition: 2nd
• Format: Paperback
• Copyright: 2001-05-03
• Publisher: Oxford University Press

Summary

This lively, highly illustrated text provides undergraduate and postgraduate students with an accessible introduction to medicinal chemistry. It covers basic principles and background, and then describes the general tactics and strategies involved in developing an effective drug. Through the use of numerous examples it highlights both the difficulties faced by the medicinal chemist and the great potential of rational drug design. The second edition has five new chapters and is updated to include recent advances in the field. Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * adrenergics * drug discovery and drug development

Table of Contents

General Principles

Drugs and the medicinal chemist

The why and the wherefore

Protein structure

Drug action at enzymes

Drug action at receptors

Receptor

Nucleic acids

Drug discovery and drug development

Drug design - drug/target interactions

Pharmacokinetics

Quantitative structure-activity relationships (QSAR)

Combinatorial synthesis

Computers in medicinal chemistry

Topics

Antibacterial agents

The peripheral nervous system-cholinergics, anticholinergics, and anticholinesterases

The adrenergic nervous system

The opium analgesics

Cimetidine - a rational approach to drug design

Appendices

Glossary

Further reading

Index

Table of Contents provided by Publisher. All Rights Reserved.