Introduction to Protein Science Architecture, Function, and Genomics

by Lesk, Arthur M.

• ISBN13: 9780199541300
• ISBN10: 0199541302
• Edition: 2nd
• Format: Paperback
• Copyright: 2010-05-20
• Publisher: Oxford University Press

Summary

Designed for students in biology, biochemistry, and biomedicine, Introduction to Protein Science, Second Edition, provides a wide-ranging introduction to the contemporary study of proteins in health and disease. The text describes basic principles of protein structure and methods for studying them, illustrates the wide variety of functions that proteins have, and shows how their structures and functions are closely linked. Introduction to Protein Science, Second Edition, relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics. It also provides a balanced treatment of the relationship between computational and experimental methods. The text is enhanced by marginal notes, exercises, problems, and "weblems" that develop students' database and computational server skills. An updated and expanded Companion Website offers resources for students and instructors. New to this edition: * Coverage of new developments in the field, including high-throughput methods * A new chapter on enzyme kinetics * Extended treatments of such topics as protein evolution and the immune system * New pedagogical features including "key points" and "Proteins in Health and Disease" boxes * New end-of-chapter exercises, problems, and "weblems"

Author Biography

Arthur M. Lesk is Professor of Biochemistry and Molecular Biology at The Pennsylvania State University. He is the author of the highly successful Introduction to Bioinformatics, and Introduction to Genomics, both published by Oxford University Press.

Table of Contents

Introduction: Proteins in their Biological Context

Fundamentals of Protein Structure

Protein Structure Determination

Structural Bioinformatics

Proteins as Catalysts: Enzyme Structure, Kinetics, and Mechanism

Protein Interactions and Assemblies

Evolution of Protein Structure and Function

Protein Folding, Engineering and Design

Proteomics and Systems Biology

Systems Biology of Proteins

Proteins in Disease

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