Investigating Neurological Disease: Epidemiology for Clinical Neurology

by Albert Hofman , Richard Mayeux

• ISBN13: 9780521000093
• ISBN10: 0521000092
• Format: Paperback
• Copyright: 2001-10-01
• Publisher: Cambridge University Press

Summary

In the clinical neurosciences, decision-making becomes ever more complicated because of rapidly emerging new diagnostic tests and treatments and increasing demands from patients to participate in their management. This concise but wide-ranging handbook reviews the epidemiology of neurological disease and the treatment and prognosis of all major diseases of the nervous system. Part one offers essential guidance for clinicians to quantitative methods in research, including genetic epidemiology, decision analysis, meta-analysis, outcomes research and survival analysis, and thus provides a good understanding of the evidence underlying clinical management. The second part is devoted to individual neurological diseases, covering etiology, diagnosis, prognosis, interventions, and implications for clinical practice. With contributions from leading international authorities, this book is an invaluable guide to clinical decision-making for neurologists and others involved in the management of neurological disease.

Table of Contents

Life of contributors	vii
Preface	xi
Part I Quantitative methods in clinical neurology
Clinical research design: analytical studies	3	(8)
Richard Mayeux
Genetic epidemiology in neurologic disease	11	(10)
Ruth Ottman
Gene-environment interaction in neurologic disorders	21	(5)
Cornelia M. van Duijn
Analysis, reanalysis, and meta-analysis in neurology	26	(17)
Walter A. Rocca
Diagnostic research in clinical neurology	43	(9)
W.A. van Gool
Decision analysis in clinical neurology	52	(18)
Diederik W. J. Dippel
Outcomes research in clinical neurology	70	(18)
Mitchell S. V. Elkind
Ralph L. Sacco
Survival analysis in neurological diseases	88	(25)
John F. Kurtzke
Mitchell T. Wallin
The clinical trial in efficacy research in neurological diseases	113	(22)
Jan van Gijn
M. Vermeulen
Part II Neurological diseases
Cerebrovascular ischemic disease	135	(10)
Philip A. Wolf
Vascular dementia	145	(9)
Richard K. Chan
Vladimir C. Hachinski
Alzheimer's disease	154	(20)
Ingmar Skoog
Kaj Blennow
Parkinson's disease	174	(22)
Maarten C. de Rijk
Monique M. B. Breteler
Multiple sclerosis	196	(9)
A. Alperovitch
Myasthenia gravis	205	(13)
Therese A. Treves
Guillain-Barre syndrome	218	(12)
F. G. A. van der Meche
R. van Koningsveld
Encephalitis and meningitis	230	(16)
Ettore Beghi
HIV infection	246	(13)
Ned C. Sacktor
Gerald J. Dal Pan
Justin C. McArthur
Prion diseases	259	(11)
Esther A. Croes
Cornelia M. van Duijn
Neoplastic disease	270	(11)
John F. Annegers
Cerebral palsy	281	(10)
Karin B. Nelson
Migraine	291	(16)
Ann I. Scher
Richard B. Lipton
Walter F. Stewart
Index	307