Lab-on-Chips for Cellomics

by Andersson, Helene; Van Den Berg, Albert

• ISBN13: 9781402065620
• ISBN10: 1402065620
• Format: Paperback
• Copyright: 2007-06-30
• Publisher: Springer Verlag

Summary

The convergence of life sciences and micro/nanotechnologies is one of the fastest growing modern R and D areas with an enormous potential societal impact. Microfluidics or Lab-on-Chip (LOC) devices, also dubbed BioMEMS, are a fascinating example of this combination of two scientific areas. This book, which is the first volume entirely dedicated to microfabricated cell-based systems, will provide readers with a quick introduction to the field as well as with a variety of specific examples of such Lab-on-Chip systems for cellomics applications. It will give investigators inspiration for innovative research topics, whereas end users will be surprised about the wide variety of new and exciting applications.

Table of Contents

List of Contributors	p. vii
Preface	p. xiii
Microfluidic devices for cellomics	p. 1
Pretreatment of biological sample for microchip analysis	p. 23
Liposomes as model cellular systems	p. 59
Versatile chip-based tool for the controlled manipulation of microparticles in biology using high frequency electromagnetic fields	p. 83
Micro-electroporation in cellomics	p. 123
Patch-clamp microsystems	p. 143
Using lab-on-a-chip technologies to understand cellular mechanotransduction	p. 171
Analysis of apoptosis on chip	p. 197
On-chip single-cell cultivation systems	p. 225
Human embryonic stem cells and microfluidics	p. 257
Cellular and subcellular analysis on chip	p. 273
Microfluidic cell-culture devices	p. 299
Micromachined bioreactor for in vitro cell self-assembly and 3D tissue formation	p. 319
Color plates	p. 347
Index	p. 361
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