Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3

by International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes (3rd : 2000 : Maui, Hawaii)

• ISBN13: 9780306472824
• ISBN10: 0306472821
• Format: Hardcover
• Copyright: 2002-06-01
• Publisher: Plenum Pub Corp

Summary

During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentionally pronounced visual disability and blindness.

Table of Contents

Conference Address

Understanding Dry Eye Syndrome

Lacrimal Gland: Cellular And Molecular Biology

GDNF Family Signaling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympathetic Neuron Development

The Influence of Aging in the Insulin Signaling System in Rat Exocrine Glands

Cloning, Partial Sequencing and Expression of Rabbit Lacrimal Grand beta-Hexosaminidase

Differential Expression of Adenylyl Cyclase mRNAs in Lacrimal Glands of NZB/NZW and NOD Pre-Autoimmune Mice

M3 Receptor Autoimmunity. Losing Tolerance to a Familair Protein

Additional Chapters. Lacrimal Gland And Ocular Surface: Signal Transduction, Membrane Traffic And Fluid And Protein Secretion

Genetic Separation of the Human Lacritin Gene and Triple A (Allgrove) Syndrome on 12Q13

Ca2 Signaling in Polarized Exocrine Cells

Role of Ca2 and Protein Kinase C in Cholinergic and alpha1-Adrenergic Agonists and EGF Stimulated Mitogen-Activated Protein Kinase Activity in Lacrimal Gland

A Model of Fluid Secretion By the Acinar Cells of the Mouse Lacimal Gland

Cytoskeletal Participation in Stimulated Secretion and Compensatory Apical Plasma Membrane Retrieval in Lacrimal Gland Acinar Cells

Additional Chapters. Mucins: Origin, Properties, Regulation And Function

Mechanism by Which Bacterial Flagellin Stimulates Host Mucin Production

Mucins and Ocular Surface Disease

Functional Processing of Ocular Mucins

ERBB2 and its Ligand MUC4 (Sialomucin Complex) in Rat Lacrimal Gland

Role of Mitogen-Activated Protein Kinase in Cholinergic Stimulation of Conjunctival Goblet Cell Secretion

Isolation and Characterization of Human Goblet Cells in vitro: Regulation of Proliferation and Activation of Mitogen-Activated Protein Kinase by EGF and Carbachol

Human Conjunctival Epithelium in Culture: A Tool to Assay New Therapeutic Strategies for Dry Eye

Additional Chapters. Meibomian Gland Art Tear Film Lipids: Structure, Function And Control

Meibomian Gland and Tear Film Lipids: Structure, Function and Control

Androgen Regulation of Lipogenesis

Sex steroids, the Meibomian Gland and Evaporative Dry Eye

The Lipid Layer and Stability of Tears in Human Newborns

Interface Properties of Simplified Tear-Like Fluids in Relation of Lipid and Aqueous Layers Composition

Additional Chapters. Ocular Surface Homeostasis

Tear Film Proteins & Stability

The Tear Film and Defense Against Infection

Nerve Growth Factor: An Important Molecule for Trophism and Healing of the Ocular Surface

Changes in the Diurnal Pattern of the Distribution of Gelatinases and Associated Proteins in Normal and Pathological Tear Fluids. Evidence That the PMN Cell is a Major Source of NNP Activity in Tear Fluid

Protection of Human Efferent Tear Ducts by Antimicrobial Peptides

Tear Lipocalin: Structure, Function and Molecular Mechanisms of Action

Additional Chapters. Ocular Surface Homeostasis

Tear Film, Cornea & Conjunctiva Interactions

Enzymatic Mechanisms in Corneal Ulceration with Specific Reference to Familial Dysautonomia: Potential for Genetic Approaches

Pathological Keratinization of Ocular Surface Epithelium

Experimentally Induced Dry Eye Produces Ocular Surface Inflammation and Epithelial Disease

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