Lecture Notes on Computational Structural Biology

by Wu, Zhijun

• ISBN13: 9789812705891
• ISBN10: 9812705899
• Format: Hardcover
• Copyright: 2008-08-01
• Publisher: World Scientific Pub Co Inc

Summary

While the field of computational structural biology or structural bioinformatics is rapidly developing, there are few books with a relatively complete coverage of such diverse research subjects studied in the field as X-ray crystallography computing, NMR structure determination, potential energy minimization, dynamics simulation, and knowledge-based modeling. This book helps fill the gap by providing such a survey on all the related subjects. Comprising a collection of lecture notes for a computational structural biology course for the Program on Bioinformatics and Computational Biology at Iowa State University, the book is in essence a comprehensive summary of computational structural biology based on the author's own extensive research experience, and a review of the subject from the perspective of a computer scientist or applied mathematician. Readers will gain a deeper appreciation of the biological importance and mathematical novelty of the research in the field.

Table of Contents

Introduction	p. 1
X-ray Crystallography Computing	p. 27
NMR Structure Determination	p. 63
Potential Energy Minimization	p. 99
Molecular Dynamics Simulation	p. 125
Knowledge-based Protein Modeling	p. 156
Design and Analysis of Computer Algorithms	p. 182
Numerical Methods	p. 202
Index	p. 229
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