Lentiviral Vectors

by Trono, Didier; Compans, R. W.; Cooper, M.; Ito, Y.; Koprowski, H.; Melchers, F.

• ISBN13: 9783540421900
• ISBN10: 3540421904
• Format: Hardcover
• Copyright: 2002-02-01
• Publisher: Springer Verlag

Summary

More Than Just a Blending of Traditional Topics Departing radically from the traditional subject-by-subject mathematics curriculum, IMP employs an integrated approach that includes important topics that are not taught in a traditional curriculumtopics such as probability, statistical reasoning, and discrete mathematics. Its problem-centered approach helps students learn to think creatively and critically, and teaches them to draw simultaneously from many areas of mathematics to solve real-life problems. IMP fortifies students with a host of other life-enriching skills, ranging from working in groups to expressing ideas orally and in writing. Results show this revolutionary approach pays off. IMP improves the mathematics proficiency of a broad range of students and encourages many students to take more mathematics than they would originally planned. And their SAT scores prove to be equal to or better than those of their peers in traditional programs! IMP Has Great Teachers Support Materials A detailed Teachers Guide for each IMP unit includes an overview, daily outlines, detailed lesson plans, discussions of the mathematics, suggested questions to stimulate discussion, transparency masters, semester assessments, and much more. There are also calculator guides for each year, a supplement called Its All Write that helps students improve their mathematical writing, and the Teaching Handbook for the Interactive Mathematics Program: A Teacher-to-Teacher Guide covering issues like homework, grading, classroom management, and forming groups.

Table of Contents

Molecular Biology of Lentivirus-Mediated Gene Transfer	1	(30)
M. Stevenson
HIV-1-Derived Lentiviral Vectors	31	(22)
L.E. Ailles
L. Naldini
Lentiviral Vectors Derived from Simian Immunodeficiency Virus	53	(22)
D. Negre
G. Duisit
P.-E. Mangeot
P. Moullier
J.-L. Darlix
F.-L. Cosset
Nonprimate Lentiviral Vectors	75	(32)
M.A. Curran
G.P. Nolan
Production of Lentiviral Vectors	107	(16)
R. Zufferey
Biosafety Issues in Lentivector Production	123	(20)
C. Delenda
M. Audit
O. Danos
Lentiviral Vector Targeting	143	(22)
A. Larochelle
K.-W. Peng
S.J. Russell
Integration Site Selection by Lentiviruses: Biology and Possible Control	165	(14)
F.D. Bushman
Improving the Post-Transcriptional Aspects of Lentiviral Vectors	179	(12)
T. Hope
Lentiviruses as Vectors for CNS Diseases	191	(20)
N. Deglon
P. Aebischer
Lentiviral Vectors for the Gene Therapy of Lympho-Hematological Disorders	211	(18)
P. Salmon
D. Trono
Lentiviral Vectors for Gene Therapy of HIV-Induced Disease	229	(16)
R.G. Amado
I.S.Y. Chen
Opportunities for the Use of Lentiviral Vectors in Human Gene Therapy	245	(10)
F. Galimi
I.M. Verma
Subject Index	255