Leukemia and Lymphoma

by Zipf, Theodore F.; Johnston, Dennis A., Ph.D.

• ISBN13: 9780896039667
• ISBN10: 0896039668
• Format: Hardcover
• Copyright: 2002-10-01
• Publisher: Humana Pr Inc

Summary

In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.

Table of Contents

Preface	v
Contributors	xi
Flow-Cytometry Methods for the Detection of Residual Leukemia	1	(20)
Richard Ratei
Wolf-Dieter Ludwig
Flow-Cytometry--Based Studies of Minimal Residual Disease in Children with Acute Lymphoblastic Leukemia	21	(16)
Dario Campana
PCR Methods for the Detection of Minimal Residual Disease in Childhood Acute Lymphoblastic Leukemia	37	(16)
Geoffrey Neale
Statistical Considerations in the Analysis of Minimal Residual Disease	53	(24)
Dennis A. Johnston
Theodore F. Zipf
The Application of Minimal Residual Disease Detection Methodology to the Clinical Decision-Making Process	77	(8)
Theodore F. Zipf
Dennis A. Johnston
Measurement of Minimal Residual Disease in Children Undergoing Allogeneic Stem Cell Transplant for Acute Lymphoblastic Leukemia	85	(12)
John Moppett
Amos Burke
Christopher Knechtli
Anthony Oakhill
Colin Steward
Nicholas J. Goulden
Molecular Investigation of Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia of B Lineage	97	(22)
Letizia Foroni
Forida Y. Mortuza
A. Victor Hoffbrand
Investigation of Minimal Residual Disease in Acute Myeloid Leukemia by Immunophenotyping	119	(18)
Jesus F. San Miguel
Maria B. Vidriales
Alberto Orfao
Minimal Residual Disease in Acute Myeloid Leukemia: RT-PCR--Based Studies of Fusion Transcripts	137	(26)
Guido Marcucci
Michael A. Caligiuri
Minimal Residual Disease in Acute Promyelocytic Leukemia	163	(16)
Francesco Lo Coco
Daniela Diverio
Minimal Residual Disease in Chronic Myelogenous Leukemia: Results of RT-PCR Detection of BCR-ABL Transcripts	179	(22)
Nicholas C. P. Cross
Andreas Hochhaus
Utility of PCR Assessment of Minimal Residual Disease After Stem Cell Transplantation in Non-Hodgkin's Lymphoma	201	(22)
Angela M. Krackhardt
John G. Gribben
Real-Time Polymerase Chain Reaction of Genomic DNA for Quantitation of t(14;18)	223	(14)
Apostolia-Marie Tsimberidou
Yunfang Jiang
Richard J. Ford
Fernando Cabanillas
Andreas H. Sarris
Monitoring Follicular Lymphoma by Polymerase Chain Reaction	237	(6)
Ming-Sheng Lee
Fernando Cabanillas
Editors' Notes	243	(6)
Index	249