Leukemias Principles and Practice of Therapy

by Faderl, Stefan; Kantarjian, Hagop

• ISBN13: 9781405182355
• ISBN10: 1405182350
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-12-13
• Publisher: Wiley-Blackwell

Summary

Edited by experts from one of the world's largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials.Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agentsLeukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Author Biography

Dr. Stefan Faderl specializes in acute and chronic leukemias. His main areas of interest include acute lymphoblastic leukemias (ALL), acute myeloid leukemias (AML), chronic lymphocytic leukemia (CLL) and its variants, as well as chronic myeloid leukemias (CML).

Dr. Hagop M. Kantarjian is Professor of Medicine and Chairman of the Department of Leukemia at MD Anderson Cancer Center in Houston, Texas. He specializes in leukemia and is interested in creating new treatment approaches for these diseases. He has authored and contributed to over 560 medical publications, articles, and abstracts.

Table of Contents

Background and Diagnostic

Stem Cell Biology in Normal and Malignant Hematopoiesis

Epidemiology and Etiology of Leukemias

Traditional Diagnostic Approaches

Diagnosis of Leukemias - New Diagnostic Modalities and Implications for Classification

Non-cytogenetic Markers and Their Impact on Prognosis

Myelodysplastic syndromes (MDS)

Myelodysplastic Syndromes: Pathophysiology

Myelodysplastic Syndromes - The Role of Cytogenetic and Molecular Abnormalities for Classification and Risk Assignment

Myelodysplastic Syndromes

Acute Myeloid Leukemia (AML)

Presentation and Diagnosis: Novel Molecular Markers and their Role in the Prognosis and Therapy of Acute Myeloid Leukemia

Induction Therapy of Acute Myeloid Leukemia

Salvage Therapy for Acute Myeloid Leukemia: Current Strategies and Emerging Therapies

Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia

Acute Promyelocytic Leukemia (APL)

The Pathophysiology of Acute Promyelocytic Leukemia

Acute Promyelocytic Leukemia (APL): Manifestations and Therapy (Sylvain Thépot

Acute Lymphoblastic Leukemia (ALL)

Acute Lymphoblastic Leukemia: Presentation, Diagnosis and Classification

Induction Therapy in Adult Acute Lymphoblastic Leukemia

Salvage Therapy of Adult Acute Lymphoblastic Leukemia

Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Current Treatment Status and Perspectives

Acute Lymphoblastic Leukemia in Adolescents and Young Adults

The Role of Hematopoietic Stem Cell Transplantation in Adults with Acute Lymphoblastic Leukemia

Chronic Myeloid Leukemia (CML)

Pathophysiology of Chronic Myeloid Leukemia

Therapy of Newly Diagnosed and Chronic Phase Chronic Myelogenous Leukemia

Therapy of Advanced Stage and Resistant Chronic Myeloid Leukemia

Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia: Pathophysiology, Diagnosis and Manifestations, and Prognostic Markers

Therapy of Chronic Lymphocytic Leukemia - Frontline and Salvage

The Role of Stem Cell Transplantation in Chronic Lymphocytic Leukemia

Special Situations: Management of Elderly Patients and CLL Transformation

Other Leukemic Disorders

Hairy Cell Leukemia

Therapeutic Approaches to the Mature T-cell Lymphoproliferative Leukaemias

Philadelphia Chromosome Negative Myeloproliferative Neoplasms

General Treatment Principles and Clinical Developments

Management of Emergencies in Leukemias

Management of Infectious Complications in Patients with Leukemia

Transfusion Support and Hematopoietic Growth Factors

New Designs for Clinical Trials: AML as an Example

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