Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control

by Collins, Tucker

• ISBN13: 9780792372233
• ISBN10: 0792372239
• Format: Hardcover
• Copyright: 2001-01-01
• Publisher: Kluwer Academic Pub

Summary

The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules. Leukocyte Recruitment, Endothelial Cell Adhesion Molecules and Transcriptional Control: Insights for Drug Discovery outlines some of the cellular and molecular mechanisms of inflammation with contributions from top researchers. This volume provides an overview of three of these endothelial adhesion molecules, as examples of key mediators of leukocyte recruitment. It reviews the structure and regulation of these cell surface proteins and focus on the rapidly expanding field of transcriptional regulation of these inducible proteins, and closes with a discussion of drug discovery possibilities that target the regulation of leukocyte recruitment. This book will be of interest for any researchers, in academia or industry, looking for an overview of leukocyte recruitment or novel approaches to drug discovery.

Table of Contents

Preface: Transcriptional Control of Cell Adhesion Molecules
Tucker Collins
Mary Gerritsen
The Selectins in Leukocyte Recruitment	1	(26)
Rodger McEver
Transcriptional Regulation of the E-Selectin Gene	27	(28)
Tucker Collins
Kelly-Ann Sheppard
Simos Simeonidis
David Rose
The Immunoglobulin Superfamily in Leukocyte Recruitment	55	(54)
Ulrich von Andrian
Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression	109	(66)
Thomas Parks
Mary Gerritsen
Transcriptional Regulation of VCAM-1	175	(28)
Andrew Neish
Sarita Aggarwal
Tucker Collins
Activation of Nuclear Factor-kB	203	(26)
Frank Lee
Robert Peters
James Chen
Thomas Maniatis
The Basal Transcriptional Apparatus	229	(34)
Stephen Anderson
Jeffrey Parvin
Therapeutic Regulation of Leukocyte Adhesion Molecule Expression	263	(40)
Mary Gerritsen
The NF-kB System and Drug Discovery	303	(20)
Anthony Manning
Index	323