The collection of chapters in this book offers a comprehensive view of the state-of-the-art in one of the fastest growing fields of neurosci ence. From the details of their atomic structure, to the devastating c onsequences of gene ablation, these pages summarize our current knowle dge on neurotrophic factors and their receptors derived from new techn iques in molecular biology, cell biology and genetics.

Preface
A Memorial Symposium for Hakan Persson
List of Contributors
Structure-Function Relationships and Mechanisms of Action of Neurotrophic Factors	p. 1
Insights into Neurotrophic Factor Function from Structural Analyses	p. 3
Functional Analysis of Receptor Binding Determinants in the Neurotrophin Family	p. 19
Signal Transduction by Trk Receptors	p. 37
On the Mechanisms by Which Neurotrophic Factors Regulate Neuronal Survival and Cell Death	p. 55
Neurotrophic Factor Receptors: Expression and Function	p. 69
The Interaction Between the Two Receptors for NGF, p75[superscript LNTR] and TrkA	p. 71
Interactions Between NGF Receptors, TrkA and p75	p. 87
Receptors and Signaling Pathways Used by the Neurotrophins, CNTF and a New Family of Neurotrophic Factors, the EFLs	p. 99
Embryonic Expression of Neurotrophin Trk Receptor mRNAs Within Sensory Neurons: Chicken Development as a Model	p. 113
Development: Proliferation and Differentiation	p. 131
Brain-Derived Neurotrophic Factor and the Developing Chick Retina	p. 133
Neurotrophins in the Developing Avian Visual System	p. 143
The Regulation and Function of NGF Receptors in Normal and Immortalized Sympathoadrenal Progenitor Cells	p. 155
Sequential Trophic Regulation of Sympathetic Neuroblast Development by NT-3 and NGF	p. 181
Effects of Brain-Derived Neurotrophic Factor and Neurotrophin-4 on Embryonic Rat Sensory Neurons	p. 193
Role of Neurotrophic Factors in Cerebellar Development	p. 205
Neurotrophins, Depolarization and Second Messengers Interact to Control Serotonergic Neuronal Differentiation	p. 217
Control of Neurotrophic Factor Synthesis and Release	p. 233
Structure and Regulation of BDNF and NT-4 Genes	p. 235
Neurotrophins as Mediators of Neuronal Plasticity	p. 261
Stimulation of Neurotrophic Factor Expression: Links to Different Forms of Brain Plasticity	p. 275
Molecular Determinants of Neurotrophin Actions in the Brain	p. 297
Gene Knock-Outs	p. 313
Neurotrophins: Essential Functions In Vivo Characterized by Targeted Gene Mutations	p. 315
Requirement for Neurotrophin-3 in the Development of the Muscle Proprioceptive System	p. 335
Life and Death in Mice Without Trk Neurotrophin Receptors	p. 345
Neurotrophic Factor Function In Vivo: Degeneration and Regeneration	p. 361
Specificity, Synergy and Autocrine Roles of the Neurotrophins and CNTF	p. 363
Therapeutic Use of Neurotrophic Factors	p. 379
NGF-Dependent Regeneration of Adult Septal Cholinergic Axons into Denervated Hippocampus	p. 391
Glial Cell Line-Derived Neurotrophic Factor Augments Midbrain Dopaminergic Circuits In Vivo	p. 401
Neurotrophins in Kindling Epilepsy: Neuronal Protection or Induction of Sprouting and Epileptogenesis?	p. 417
Concluding Remarks	p. 439
Future Directions and Clinical Prospects of Neurotrophic Factor Research	p. 441
Hakan Persson Publication list	p. 453
Subject Index	p. 467
Table of Contents provided by Blackwell. All Rights Reserved.

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