Lippincott's Cancer Chemotherapy Handbook

by Baquiran, Delia C.; Gallagher, Jean

• ISBN13: 9780781726467
• ISBN10: 0781726468
• Edition: 2nd
• Format: Paperback
• Copyright: 2001-02-06
• Publisher: LWW

Summary

The Second Edition of Lippincott's Cancer Chemotherapy Handbook is a practical, yet comprehensive, reference guide that provides alphabetical access to cancer drugs and to drug administration guidelines. Written by two high level nurses at Memorial-Sloan Kettering Cancer Center, this book is a valuable resource for practicing nurses, physicians, IV therapists, and other oncology health care providers. The main section includes chemotherapeutic drug monographs, drug regimens, and information on drugs needed to control side effects. New to this edition are brief sections that detail the guidelines on safe handling and administration, management of side effects, and home care guidelines.

Table of Contents

I. Cancer Chemotherapy	1	(174)
Overview of Chemotherapy	3	(10)
The Cell Cycle	4	(2)
Cancer Cell Characteristics	6	(2)
Cellular Kinetics	6	(2)
Classification of Chemotherapeutic Agents	8	(3)
Cell Cycle--Specific Agents: Antimetabolites, Vinca Alkaloids, Epipodophyllotoxins, Taxanes, Camptothecins	8	(1)
Cell Cycle---Nonspecitic Agents: Alkylating Agents, Nitrosoureas, Antitumor Antibiotics, Hormones, Hormone Antagonists	9	(2)
Miscellaneous Agents	11	(1)
Combination Chemotherapy	11	(2)
Biologic Response Modifiers	13	(29)
Janet Gordils-Perez
Biologic Response Modifiers	15	(1)
Monoclonal Antibodies	16	(5)
Toxicities	21	(1)
Cytokines	21	(11)
Interferons	21	(5)
Hematopoietic Growth Factors	26	(4)
Interleukins	30	(1)
Tumor Necrosis Factor	31	(1)
Additional Biologic Agents and Approaches	32	(1)
Vaccine Therapy	32	(1)
Gene Therapy	33	(1)
Handling and Preparation	33	(1)
Patient and Family Education	34	(7)
Management of Side Effects and Toxicities	41	(1)
Clinical Trials	42	(9)
Clinical Trials	42	(1)
Drug Development	43	(1)
Three Phases of Clinical Trials	43	(2)
The Research Protocol: From Concept to Implementation	45	(2)
Informed Consent	47	(1)
The Economics of Clinical Trials	48	(1)
Institutional Review Board	49	(1)
Role of the Nurse in Clinical Trials	49	(2)
Patient Care	49	(1)
Data Management	50	(1)
Education and Protocol Development	50	(1)
Preparation, Administration, and Handling of Chemotherapy	51	(34)
Ensuring Patient Safety: Preventing Chemotherapy Errors	51	(3)
Calculating Chemotherapy Dosages	54	(1)
Pretreatment Assessment	54	(3)
Routes of Administration	57	(7)
Oral	57	(1)
Intramuscular/Subcutaneous	57	(1)
IV Side Arm	58	(1)
IV Push	58	(1)
IV Piggyback	58	(1)
Continuous Intravenous Infusion	58	(1)
Intraperitoneal Chemotherapy	58	(2)
Intrahepatic Chemotherapy	60	(2)
Intrathecal/Intraventricular	62	(1)
Intravesical	62	(1)
Intrapleural	63	(1)
Central Venous Access Devices (CVADs)	64	(8)
Selection	64	(1)
Routine Care	64	(1)
Serum Sampling	65	(7)
Complications and Management	72	(1)
Ambulatory Infusion Pumps	72	(8)
Safe Handling and Disposal of Chemotherapy	80	(5)
Minimizing Exposure to Chemotherapeutic Agents	81	(1)
Measures for Accidential Exposure to Chemotherapy	82	(2)
Management of Chemotherapy Spills	84	(1)
Management of Toxic Effects of Chemotherapy	85	(56)
Cardiotoxicity	86	(4)
Management and Patient Education	87	(3)
Cutaneous Toxicity	90	(8)
Alopecia	90	(4)
Acral Erythema (Hand-Foot Syndrom)	94	(1)
Hyperpigmentation	95	(1)
Nail Changes	96	(1)
Photosensitivity	96	(1)
Radiation Enhancement and Recall	97	(1)
Gastrointestinal Toxicity	98	(15)
Nausea and Vomiting	98	(9)
Anorexia	107	(1)
Mucositis	108	(3)
Constipation	111	(1)
Diarrhea	112	(1)
Hematologic Toxicity	113	(9)
Myelosuppression	113	(5)
Anemia	118	(1)
Neutropenia	119	(2)
Thrombocytopenia	121	(1)
Hepatoxicity	122	(1)
Management and Patient Education	122	(1)
Fatigue	123	(2)
Management and Patient Education	123	(2)
Nephrotoxicity	125	(4)
Management and Patient Education	129	(1)
Neurotoxicity	129	(2)
Pulmonary Toxicity	131	(5)
Management and Patient Education	136	(1)
Sexuality and Fertility Effects of Chemotherapy	136	(5)
Gonadal Dysfunction	137	(1)
Infertility	137	(1)
Testicular Dysfunction	137	(1)
Teratogenicity and Mutagenicity	138	(1)
Management and Patient Education	138	(3)
Management of Hypersensitivity Reactions and Extravasation	141	(20)
Hypersensitivity Reactions	141	(4)
Nursing Management	144	(1)
Extravasation	145	(16)
Care of the Patient Receiving Vesicant Chemotherapy	147	(8)
Techniques for Vesicant Administration	155	(1)
Management of Suspected or Actual Extravasation	156	(3)
Patient Education in Vesicant Administration	159	(2)
Patient Education	161	(14)
The Dot.com: The Role of the Internet in Patient Education	162	(1)
Nursing Process in Patient Education	163	(8)
Assessment and Planning	163	(1)
Implementation	164	(5)
Evaluation	169	(1)
Documentation	170	(1)
Home Care	171	(4)
Bibliography	175	(18)
II. Chemotherapeutic Agents, Biologic Response Modifiers, and Chemoprotectants	193	(158)
III. Combination Chemotherapy Regimens	351	(144)
APPENDICES
Appendix A National Cancer Institute Publications for Cancer Patients and the Public	377	(9)
Appendix B Sample Patient Education Material	386	(2)
Appendix C Yellow Pages for Cancer Patients and Caregivers	388	(26)
Appendix D National Cancer Institute (NCI) Toxicity Scale	414	(81)
Index	495