The Liver Biology and Pathobiology

by Arias, Irwin M.; Boyer, James L.; Chisari, Francis V.; Fausto, Nelson; Schachter, David; Shafritz, David A.

• ISBN13: 9780781723909
• ISBN10: 0781723906
• Edition: 4th
• Format: Hardcover
• Copyright: 2001-07-19
• Publisher: LWW

Summary

The first major text to link the discoveries of basic biology to the understanding and clinical management of liver diseases, The Liver: Biology and Pathobiology has long been a classic in gastroenterology and hepatology. Now, this landmark work has been thoroughly revised and updated to reflect recent groundbreaking achievements in the laboratory and clinic. More than 100 world-renowned investigators provide a definitive account of current concepts on the structure and function of the liver and the mechanisms underlying liver diseases. This edition has been pared down to a smaller, more user-friendly size and focused more sharply on the most important advances. A Brandon-Hill recommended title.

Table of Contents

Contributing Authors	xi
Preface	xvii
Acknowledgments	xix
Indicates chapters from third edition posted on website http://liver.med.tufts.edu
PART I: INTRODUCTION
Organizational Principles	3	(14)
Valeer J. Desmet
Embryonic Development of the Liver	17	(12)
Kenneth S. Zaret
PART II: THE CELLS
Biology and Pathobiology of Actin in the Liver
M. James Phillips
Cytoskeleton: Intermediate Filaments
Samuel W. French
Gap and Tight Junctions in Liver: Composition, Regulation, and Function	29	(18)
Takashi Kojima
Norimasa Sawada
Heather S. Duffy
David C. Spray
Motor Molecules	47	(12)
Peter Satir
Motor Molecules of the Cytoskeleton: Possible Functions in the Hepatocyte
Peter Satir
Gene Regulation and In Vivo Function of Liver Transcription Factors	59	(18)
Robert H. Costa
Ai-Xuan Le Holterman
Francisco M. Rausa
Guy R. Adami
The Hepatocyte Plasma Membrane: Organization, Differentiation, Biogenesis, and Turnover	77	(6)
David Schachter
Plasma Membrane: Biogenesis and Turnover
Mamadi Yilla
Darrell Doyle
Hepatocyte Basolateral Membrane Organic Anion Transporters	83	(14)
Allan W. Wolkoff
Frederick J. Suchy
The Hepatocyte Surface: Dynamic Polarity	97	(22)
Pamela L. Tuma
Ann L. Hubbard
Hepatocyte Surface Polarity
Ann L. Hubbard
Valarie A. Barr
Laura J. Scott
The Endoplasmic Reticulum and Golgi Complex in Secretory Membrane Transport	119	(14)
Jennifer Lippincott-Schwartz
The Endoplasmic Reticulum-Golgi Membrane System
Jennifer Lippincott-Schwartz
Mechanisms of Nuclear Entry
John A. Hanover
Molecular Mechanisms of Hepatocellular Vesicle Formation	133	(28)
Sophie Dahan
Michael Dominguez
Mark A. McNiven
Receptor-Mediated Endocytosis	161	(18)
Richard J. Stockert
Peroxisomal Assembly, Biology, and Disease Relationship	179	(8)
Jennifer J. Smith
Richard A. Rachubinski
Peroxisomes
Paul B. Lazarow
Lysosomes
G. Gary Sahagian
Phyllis M. Novikoff
Mitochondria
Peter C. Hinkle
Section A: Hepatocyte: Metabolism
Energy Metabolism
Sam Seifter
Sasha England
Integrated Cell Function: Apoptosis	187	(20)
Martina Muller
Peter H. Krammer
Fundamentals of Cellular Osmoregulation	207	(10)
Kevin Strange
Roles of Intracellular Proteolysis in Hepatocyte Cell-Cycle, Aging, and Programmed Cell Death	217	(14)
J. Fred Dice
Regulation of Hepatic Cholesterol Homeostasis	231	(18)
Phillip B. Hylemon
William M. Pandak
Z. Reno Vlahcevic
Lipoprotein Metabolism
Robert M. Glickman
Seymour M. Sabesin
Leptin and the Liver	249	(8)
Lee M. Kaplan
Hypoxic, Ischemic, and Reperfusion Injury to Liver	257	(24)
John J. Lemasters
Protective Mechanisms Against Reactive Oxygen Species	281	(10)
Masayasu Inoue
Reactive Oxygen Species
Masayasu Inoue
Detoxication: Oxidation and Reduction
Daniel M. Ziegler
Detoxication: Conjugation and Hydrolysis
William B. Jakoby
Disorders of Bilirubin Metabolism	291	(20)
Namita Roy Chowdhury
Irwin M. Arias
Allan W. Wolkoff
Jayanta Roy Chowdhury
Heme and Bile Pigment Metabolism
Jayanta Roy Chowdhury
Namita Roy Chowdhury
Allan W. Wolkoff
Irwin M. Arias
The Porphyrias	311	(20)
Peter N. Meissner
Richard J. Hift
Ralph E. Kirsch
Heme Biosynthesis, the Porphyrias, and the Liver
Elizabeth E. Wyckoff
James P. Kushner
Copper Metabolism and the Liver	331	(14)
Iqbal Hamza
Jonathan D. Gitlin
Copper and Zinc
Inmin Sternlieb
The Liver and Iron	345	(16)
Mark D. Fleming
Nancy C. Andrews
Liver and Iron
Stephen P. Young
Philip Aisen
Retinoid (Vitamin A) Metabolism and the Liver
William S. Blaner
Liver in Relation to Water-Soluble Vitamins
Donald B. McCormick
Hamish N. Munro
Section B: Bile Secretion
The Biology of the Bile Canaliculus	361	(12)
Peter Ujhazy
Helmut Kipp
Suniti Misra
Yoshiyuki Wakabayashi
Irwin M. Arias
Bile Acids
Alan F. Hofmann
Enterohepatic Circulation
Martin C. Carey
William C. Duane
Bile Flow
Serge Erlinger
Conjugate Export Pumps of the Multidrug Resistance Protein (MRP) Family in Liver	373	(10)
Dietrich Keppler
Jorg Konig
Anne T. Nies
Genetic Defects of Canalicular Transport	383	(6)
Richard J. Thompson
Sandra S. Strautnieks
Hormonal Regulation of Bile Secretion	389	(22)
Francis R. Simon
Nucleotide Transport and Regulation of Bile Formation	411	(10)
Richard M. Roman
J. Gregory Fitz
The Pathobiology of Biliary Epithelia	421	(16)
Gianfranco Alpini
Richard T. Prall
Nicholas F. LaRusso
The Biology of Biliary Epithelia
Gianfranca Alpini
John O. Phillips
Nicholas F. LaRusso
Section C: Sinusoidal Cells
Endothelial and Pit Cells	437	(18)
Filip Braet
Dianzhong Luo
Ilan Spector
David Vermijlen
Eddie Wisse
Hepatic Stellate Cells: Morphology, Function, and Regulation	455	(14)
Dan Li
Scott L. Friedman
Kupffer and Sinusoidal Endothelial Cells
Johan Kuiper
Adriaan Brouwer
Dick L. Knook
Theo J. C. van Berkel
Section D: Extracellular Matrix
The Extracellular Matrix of the Liver	469	(6)
Patricia Greenwel
Marcos Rojkind
Extracellular Matrix
Marcos Rojkind
Patricia Greenwel
Integrins	475	(10)
Lucia R. Languino
Rebecca G. Wells
Cell-Extracellular Matrix Interactions
Erkki Ruoslahti
Michael D. Pierschbacher
Wayne A. Border
PART III: INTERRELATED CELL FUNCTIONS
Role of Inositol Trisphosphate and Diacylglycerol in the Regulation of Liver Function	485	(10)
John H. Exton
Synthesis of and Signaling Through D-3 Phosphoinositides	495	(16)
Rial A. Christensen
Isabel De Aos Scherpenseel
Lyuba Varticovski
Insulin and Other Growth Factors	511	(14)
M. Dodson Michael
Neil B. Ruderman
Insulin, Insulin-Like Growth Factors and Their Receptors
Neil Ruderman
Alan C. Moses
David E. Moller
Cyclic AMP Signaling in the Liver: Coupling Transcription to Physiology and Proliferation	525	(12)
Giuseppe Servillo
Maria Agnese Della Fazia
Paolo Sassone-Corsi
Ca2+ Signaling in the Liver	537	(18)
Maria de Fatima Leite
Michael H. Nathanson
Nitric Oxide in the Liver	555	(10)
Mark G. Clemens
Interleukin-6 Signaling During the Acute-Phase Response of the Liver	565	(16)
Johannes G. Bode
Peter C. Heinrich
Leukotrienes and Other Eicosanoids in Liver Pathophysiology
Dietrich Keppler
Innate Immune Sensing and the Toll-Like Receptors	581	(10)
Bruce Beutler
Liver Regeneration	591	(20)
Nelson Fausto
Liver Regeneration
Nelson Fausto
Eric M. Webber
Hepatocyte Growth Factor: Its Role in Hepatic Growth and Pathobiology	611	(22)
Reza Zarnegar
Marie C. DeFrances
George K. Michalopoulos
PART IV: THE ORGAN
Hepatic Microvascular System
Robert S. McCuskey
Flow, Cell Entry, Metabolic Disposal, and Product Formation in the Liver
Carl A. Goresky
Andreas J. Schwab
K. Sandy Pang
PART V: RELATION TO OTHER ORGANS
Hepatic Encephalopathy	633	(16)
Roger F. Butterworth
Alterations of the Kidney in Liver Disease	649	(14)
Paolo Gentilini
Giacomo Laffi
Massimo Pinzani
Giorgio La Villa
Kidney in Liver Disease
Murray Epstein
Interaction of Liver, Muscle, and Adipose Tissue in the Regulation of Metabolism in Response to Nutritional and Other Factors
Marc K. Hellerstein
Hamish N. Munro
Hypothalamic-Pituitary-Liver Axis: Growth Hormone Controls Liver Sex
Jan-Ake Gustafsson
Vitamin K-Dependent Blood Coagulation Proteins
Barbara C. Furie
Bruce Furie
Hemopoietic Functions of the Liver
Allan J. Erslev
Hepatobiliary Influences on the Skeletal System
Joel B. Mason
Irwin H. Rosenberg
Molecular Aspects of Autoimmune Liver Disease
Ian R. Mackay
PART VI: PATHOBIOLOGIC ANALYSIS
Molecular Pathophysiology of Membrane Transport Function in Cholestasis	663	(16)
James L. Boyer
The Biology of Portal Hypertension	679	(20)
Roberto J. Groszmann
Mauricio R. Loureiro-Silva
Ming-Hung Tsai
α1-Antitrypsin Deficiency	699	(22)
David H. Perlmutter
Pathophysiology of Liver Fibrosis	721	(18)
Marcos Rojkind
Patricia Greenwel
Alcoholic and Nonalcoholic Steatohepatitis	739	(16)
Anna Mae Diehl
Ethanol and the Liver
Francis R. Weiner
Silvia Degli Esposti
Mark A. Zern
Schistosomiasis: A Model of Immunologically Mediated Liver Disease	755	(8)
Miguel J. Stadecker
Hector J. Hernandez
Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis	763	(20)
Carlo Ferrari
Francis V. Chisari
Epidemiology, Natural History, and Prevention of Viral Hepatitis	783	(18)
Miriam J. Alter
Beth P. Bell
Molecular Bases of Hepatitis B-and Hepatitis C-Related Chronic Liver Disease	801	(30)
Christian Brechot
Molecular Biology of Hepatitis Viruses	831	(26)
Michael M. C. Lai
William S. Mason
Liver Transplantation: Factors Affecting the Balance Between Tolerance and Rejection in Experimental Models	857	(16)
Lina Lu
Shiguang Qian
Angus W. Thomson
The Woodchuck Model of Hepatitis B Virus Infection
Bud C. Tennant
John L. Gerin
Viral Hepatitis: Antiviral Therapy	873	(28)
Joseph Torresi
Stephen Locarnini
PART VII: HORIZONS
Tissue Engineering of the Liver	901	(8)
Antonia E. Stephen
Robert Langer
Joseph P. Vacanti
A Genomic View of Hepatology: The Example of Liver Fibrosis	909	(8)
Jose M. Lora
Deborah N. Farlow
Nadine Weich
Jose-Carlos Gutierrez-Ramos
After Proteomics Comes Glycomics: How Proteins and Saccharides Interact and Influence Cell Biology	917	(10)
Ram Sasisekharan
Zachary Shriver
Uma Narayanasami
Ganesh Venkataraman
Liver Repopulation Through Cell Transplantation	927	(14)
David A. Shafritz
Mariana D. Dabeva
Markus Grompe
Liver-Directed Gene Therapy	941	(22)
Clifford J. Steer
Betsy T. Kren
Namita Roy Chowdhury
Jayanta Roy Chowdhury
Novel Strategies for Manipulating Hepatic Gene Expression In Vivo	963	(14)
Marxa L. Figueiredo
Eric P. Sandgren
Regulation of the Eukaryotic Cell Cycle	977	(10)
David F. Crawford
Helen Piwnica-Worms
Molecular and Cellular Control of Angiogenesis	987	(8)
Patricia A. D'Amore
Ira M. Herman
Dynamics of Hepatitis B Virus Infection	995	(6)
Martin A. Nowak
Telomeres and Telomerase in Experimental Liver Cirrhosis	1001	(12)
Karl Lenhard Rudolph
Ronald A. DePinho
Mechanism(s) of Hepatocarcinogenesis: Insight from Transgenic Mouse Models	1013	(16)
Snorri S. Thorgeirsson
Orphan Nuclear Receptors and Regulation of Cholesterol and Bile Acid Metabolism	1029	(12)
Joyce J. Repa
Makoto Makishima
Timothy T. Lu
David J. Mangelsdorf
Subject Index	1041