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Irwin Arias, MD, National Institutes of Health, Bethesda, Maryland.? Professor of Physiology, Emeritus, Tufts University School of Medicine, Boston, Mass.? Visiting Professor of Medicine, Albert Einstein College of Medicine, Bronx, NY.
Associate editors:
James L. Boyer, Yale University School of Medicine, New Haven, CT, USA
David Shafritz, Albert Einstein College of Medicine, Bronx, NY, USA
Nelson Fausto, Professor and Chair, Department of Pathology, University of Washington, Seattle, WA, USA.
Harvey Alter, Department of Transfusion Medicine, National Institutes of Health, Bethesda, Maryland, USA
David E. Cohen,.Division of Gastroenterology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Allan Wolkoff, Albert Einstein College of Medicine, Bronx, NY, USA
| List of Contributors | |
| Preface | |
| Acknowledgements | |
| Introduction | |
| Organizational Principles of the Liver | |
| Embryonic Development of the Liver | |
| The Cells | |
| Microtubules, Actin Filaments and Motor-mediated Vesicular Transport | |
| Molecular Motors | |
| Ion Pumps and Molecular Motors: P-, F-, and V-type ATPases | |
| Hepatocyte Surface Polarity: Its Dynamic Maintenance and Establishment | |
| Endocytosis as an Essential Process in Liver Function and Pathology | |
| Membrane Transport in Hepatocellular Secretion | |
| Mitochondria | |
| Nuclear Pore Complex | |
| Protein Maturation and Processing at the Endoplasmic Reticulum | |
| Protein Degradation and the Lysosomal System | |
| Peroxisome Assembly, Degradation, and Disease | |
| Gap and Tight Junctions in Liver: Composition, Regulation, and Function | |
| Hepatocyte | |
| Copper Metabolism and the Liver | |
| The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis | |
| Disorders of Bilirubin Metabolism | |
| GH4.21. The porphyrias | |
| Hepatic fatty acid metabolism and dysfunction | |
| Lipoprotein Metabolism and Cholesterol Balance | |
| Bile Secretion | |
| Bile Acids and the Enterohepatic Circulation | |
| Hepatocyte Basolateral Membrane Organic Anion Transporters | |
| Nuclear Receptors Regulate Bile Acid Synthesis | |
| GH4.27. Hormonal regulation of bile secretion | |
| GH4.28. Nucleotide transport and regulation of bile formation | |
| The Function of the Canalicular Membrane in Bile Formation and Secretion | |
| Apical Recycling of Canalicular ABC Transporters | |
| Cholangiocyte Functions in Health and Disease: The Ciliary Connection | |
| Sinusoidal Cells | |
| The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology | |
| GH4.30. Endothelial and pit cells | |
| Fenestrations in the Liver Sinusoidal Endothelial Cell | |
| Hepatic Stellate Cells | |
| Hepatic Fibrosis | |
| Matrix | |
| Interrelated Cell Functions | |
| Insulin Resistance | |
| Ca2+ Signaling in the Liver | |
| GH4.35 Synthesis of and signalling through D-3 phosphoinositides | |
| GH4.39. Nitric oxide in the liver | |
| Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury | |
| GH4.18. Hypoxic, Ischemic and reperfusion injury to liver | |
| GH4.19. Protective mechanisms against reactive oxygen species | |
| Regulatory Pathways of Liver Gene Expression: The Central Role of Cyclic AMP | |
| AMPK: Central Regulator of Glucose and Lipid Metabolism | |
| GH3.16. Energy Metabolism | |
| Liver Regeneration | |
| GH4.40. Interleukin-6 signaling during the acute-phase response of the liver | |
| GH4.43. Hepatocyte growth factor: its role in hepatic growth and pathobiology | |
| Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver | |
| GH4.5. Gene regulation and in vivo function of liver transcription factors | |
| Liver Repopulation by Cell Transplantation and the Role of Stem Cells | |
| Relation to Other Organs | |
| Hepatic Encephalopathy | |
| The Kidney in Liver Disease | |
| Critical Role of the Liver in Coagulation | |
| Pathobiological Analysis | |
| Inheritable Cholestatic Disorders | |
| GH4.48. Alpha 1-Antitrypsin deficiency | |
| Adaptive Regulation of Hepatocyte Transporters in Cholestasis | |
| Pathogenesis of Portal Hypertension | |
| Non-alcoholic Fatty Liver Disease: A Pathophysiological Perspective | |
| Pathophysiology of Alcoholic Liver Disease | |
| Inflammation and Drug-induced Liver Injury | |
| Hepatocyte Apoptosis | |
| Back to the Future: A Backward Glance at the Forward Progress of Hepatitis Virus Research | |
| Molecular Biology of Hepatitis Viruses | |
| Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis | |
| GH4.41. Innate immune sensing and the toll-like receptors | |
| Clinical Implications of the Molecular Biology of Hepatitis B Virus | |
| Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection | |
| Current and Future Therapy for Hepatitis B and C | |
| Biological Principles and Clinical Issues Underlying Liver Transplantation for Virus-induced End-stage Liver Disease | |
| Horizons | |
| Tissue Engineering of the Liver | |
| Aging and the Uncertain Roles of Sirtuins | |
| The Liver Proteome | |
| Liver-directed Gene Therapy | |
| GH4.63. Novel strategies for manipulating hepatic gene expression in vivo | |
| Decoding the Liver Cancer Genome | |
| Genome-wide Expression Profiling of Human Hepatocellular Carcinoma | |
| Cell Cycle Control in the Liver | |
| miRNAs and Liver Biology | |
| Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster | |
| Zebrafish as a Model System for the Study of Liver Development and Disease | |
| The Hepatocyte and the Cancer Cell: Dr Jekyll and Mr Hyde | |
| The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions | |
| Telomeres and Aging, Cancer, and Hepatic Fibrosis | |
| Treatment of Cirrhosis with Vitamin A-coupled Liposomes Carrying siRNA against Heat Shock Protein 47 | |
| The ôGreen Liver" and Transcriptional Regulation of Phase II Detoxification Genes | |
| Index | |
| Table of Contents provided by Publisher. All Rights Reserved. |
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