The Liver: Biology and Pathobiology, 5th Edition

by Editor: Irwin Arias (National Institutes of Health, Bethesda, Maryland, USA); Co-Editor: Allan Wolkoff (Albert Einstein College of Medicine, Bronx, NY, USA ); Co-Editor: James Boyer (Yale University School of Medicine, New Haven, USA ); Co-Editor

• ISBN13: 9780470747902
• ISBN10: 0470747900
• Format: eBook
• Copyright: 2009-09-01
• Publisher: Wiley

Summary

In its Fifth Edition, this classic book retains its traditional strength of relating molecular physiology to understanding disease pathology and treatment as it explores the current state and future direction of hepatology.Painstakingly revised, this edition includes 60 new chapters. As in previous editions, a section called Horizons summarizes advances of extraordinary nature in areas expected to have a substantial impact on hepatology. The Fifth Edition's Horizons section includes emerging topics such as tissue engineering of the liver, liver-directed gene therapy, decoding the liver cancer genome, and imaging cellular proteins and structure.To preserve essential background information which has not changed while making room for the panoply of major new contributions to understanding of liver disease, 14 chapters from the previous edition are freely available online at gastrohep.com. To view these chapters visit - http://www.gastrohep.com/theliver/

Table of Contents

List of Contributors

Preface

Acknowledgements

Introduction

Organizational Principles of the Liver

Embryonic Development of the Liver

The Cells

Microtubules, Actin Filaments and Motor-mediated Vesicular Transport

Molecular Motors

Ion Pumps and Molecular Motors: P-, F-, and V-type ATPases

Hepatocyte Surface Polarity: Its Dynamic Maintenance and Establishment

Endocytosis as an Essential Process in Liver Function and Pathology

Membrane Transport in Hepatocellular Secretion

Mitochondria

Nuclear Pore Complex

Protein Maturation and Processing at the Endoplasmic Reticulum

Protein Degradation and the Lysosomal System

Peroxisome Assembly, Degradation, and Disease

Gap and Tight Junctions in Liver: Composition, Regulation, and function

Hepatocyte

Copper Metabolism and the Liver

The Central Role of the Liver in Iron Storage and Regulation of Systemic Iron Homeostasis

Disorders of Bilirubin Metabolism

Hepatic fatty acid metabolism and dysfunction

Lipoprotein Metabolism and Cholesterol Balance

Bile Secretion

Bile Acids and the Enterohepatic Circulation

Hepatocyte Basolateral Membrane Organic Anion Transporters

Nuclear Receptors Regulate Bile Acid Synthesis

Hormonal regulation of bile secretion

Nucleotide transport and regulation of bile formation

The Function of the Canalicular Membrane in Bile Formation and Secretion

Apical Recycling of Canalicular ABC Transporters

Cholangiocyte Functions in Health and Disease: The Ciliary Connection

Sinusoidal Cells

The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology

Endothelial and pit cells

Fenestrations in the Liver Sinusoidal Endothelial Cell

Hepatic Stellate Cells

Hepatic Fibrosis

Matrix

Interrelated Cell Functions

Insulin Resistance

Ca2+ Signaling in the Liver

Synthesis of and signalling through D-3 phosphoinositides

Nitric oxide in the liver

Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury

Hypoxic, Ischemic and reperfusion injury to liver

Protective mechanisms against reactive oxygen species

Regulatory Pathways of Liver Gene Expression: The Central Role of Cyclic AMP

AMPK: Central Regulator of Glucose and Lipid Metabolism

Energy Metabolism

Liver Regeneration

Interleukin-6 signaling during the acute-phase response of the liver

Hepatocyte growth factor: its role in hepatic growth and pathobiology

Ribosome Biogenesis and its Role in Cell Growth and Proliferation in the Liver

Gene regulation and in vivo function of liver transcription factors

Liver Repopulation by Cell Transplantation and the Role of Stem Cells

Relation To Other Organs

Hepatic Encephalopathy

The Kidney in Liver Disease

Critical Role of the Liver in Coagulation

Pathobiological Analysis

Inheritable Cholestatic Disorders

Alpha 1-Antitrypsin deficiency

Adaptive Regulation of Hepatocyte Transporters in Cholestasis

Pathogenesis of Portal Hypertension

Non-alcoholic Fatty Liver Disease: A Pathophysiological Perspective

Pathophysiology of Alcoholic Liver Disease

Inflammation and Drug-induced Liver Injury

Hepatocyte Apoptosis

Back to the Future: A Backward Glance at the Forward Progress of Hepatitis Virus Research

Molecular Biology of Hepatitis Viruses

Immune Mechanisms of Viral Clearance and Disease Pathogenesis During Viral Hepatitis

Innate immune sensing and the toll-like receptors

Clinical Implications of the Molecular Biology of Hepatitis B Virus

Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection

Current and Future Therapy for Hepatitis B and C

Biological Principles and Clinical Issues Underlying Liver Transplantation for Virus-induced End-stage Liver Disease

Horizons

Tissue Engineering of the Liver

Aging and the Uncertain Roles of Sirtuins

The Liver Proteome

Liver-directed Gene Therapy

Novel strategies for manipulating hepatic gene expression in vivo

Decoding the Liver Cancer Genome

Genome-wide Expression Profiling of Human Hepatocellular Carcinoma

Cell Cycle Control in the Liver

miRNAs and Liver Biology

Imaging Cellular Proteins and Structures: Smaller, Brighter, and Faster

Zebrafish as a Model System for the Study of Liver Development and Disease

The Hepatocyte and the Cancer Cell: Dr Jekyll and Mr Hyde

The Role of Endocannabinoids and Their Receptors in the Control of Hepatic Functions

Telomeres and Aging, Cancer, and Hepatic Fibrosis

Treatment of Cirrhosis with Vitamin A-coupled Liposomes Carrying siRNA against Heat Shock Protein 47

The "Green Liver" and Transcriptional Regulation of Phase II Detoxification Genes

Index

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