Eugene V. Koonin is a Senior Investigator at the National Center for Biotechnology Information (National Library of Medicine, National Institutes of Health), as well as the Editor-in-Chief of the journal Biology Direct. Dr. Koonin’s group performs research in many areas of evolutionary genomics, with a special emphasis on whole-genome approaches to the study of major transitions in life’s evolution, such as the origin of eukaryotes, the evolution of eukaryotic gene structure, the origin and evolution of different classes of viruses, and evolutionary systems biology. Dr. Koonin is the author of more than 600 scientific articles and a previous book Sequence--Evolution--Function: Computational Approaches in Comparative Genomics (with Michael Galperin [2002] New York: Springer).
Preface: Toward a postmodern synthesis of evolutionary biology vii
Chapter 1: The fundamentals of evolution: Darwin and Modern Synthesis 1
Chapter 2: From Modern Synthesis to evolutionary genomics: Multiple processes and patterns of evolution 21
Chapter 3: Comparative genomics: Evolving genomescapes 49
Chapter 4: Genomics, systems biology, and universals of evolution: Genome evolution as a phenomenon of statistical physics 81
Chapter 5: The web genomics of the prokaryotic world: Vertical and horizontal flows of genes, the mobilome, and the dynamic pangenomes 105
Chapter 6: The phylogenetic forest and the quest for the elusive Tree of Life in the age of genomics 145
Chapter 7: The origins of eukaryotes: Endosymbiosis, the strange story of introns, and the ultimate importance of unique events in evolution 171
Chapter 8: The non-adaptive null hypothesis of genome evolution and origins of biological complexity 225
Chapter 9: The Darwinian, Lamarckian, and Wrightean modalities of evolution, robustness, evolvability, and the creative role of noise in evolution 257
Chapter 10: The Virus World and its evolution 293
Chapter 11: The Last Universal Common Ancestor, the origin of cells, and the primordial gene pool 329
Chapter 12: Origin of life: The emergence of translation, replication, metabolism, and membranes--the biological, geochemical, and cosmological perspectives 351
Chapter 13: The postmodern state of evolutionary biology 397
Appendix A: Postmodernist philosophy, metanarratives, and the nature and goals of the scientific endeavor 421
Appendix B: Evolution of the cosmos and life: Eternal inflation, “many worlds in one,” anthropic selection, and a rough estimate of the probability of the origin of life 431
References 439
Endnotes 479
Acknowledgments 495
About the author 497
Index 499
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