Longevity Health Sciences The Phoenix Conference, Volume 1055

by Cutler, Richard G.; Harman, S. Mitchell; Heward, Chris; Gibbons, Mike

• ISBN13: 9781573315623
• ISBN10: 1573315621
• Edition: 1st
• Format: Paperback
• Copyright: 2005-12-23
• Publisher: Wiley-Blackwell

Summary

Exciting papers by leading researchers are integrated in this volume with presentations having direct clinical relevance: thus, the latest scientific advances in aging research are coupled with reports on how these advances are being applied to longevity medicine.Topics include oxidative stress, genetic/biochemical mechanisms, hormone therapy, nutrition, fitness, and exercise, all as they pertain to aging.In exploring the links between the latest basic gerontological research and the practice of longevity medicine, the current challenges faced by both scientists and clinicians engaged in combating aging and its consequences are presented here. This volume is readily accessible to the educated reader who is interested in learning more about how to reduce the negative impact of aging on human health and longevity.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Richard G. Cutler and S. Mitchell Harman are the authors of Longevity Health Sciences: The Phoenix Conference, Volume 1055, published by Wiley.

Table of Contents

Preface.
By RICHARD G. CUTLER	ix
The Involvement of Thioredoxin and Thioredoxin Binding Protein-2 on Cellular Proliferation and Aging Process.
By TORU YOSHIDA, HAJIME NAKAMURA, HIROSHI MASUTANI, AND JUNE YODOI	1	(12)
The Different Paths to Age One Hundred.
By THOMAS PERLS	13	(13)
Genetic Engineering of Mice to Test the Oxidative Damage Theory of Aging.
By GEORGE M. MARTIN	26	(9)
Aging and Genome Maintenance.
By JAN VIJG, RITA A. BUSUTTIL, RUMANA BAHAR, AND MARTIJN E.T. DOLLÉ	35	(13)
The Use of Genetic SNPs as New Diagnostic Markers in Preventive Medicine.
By CHARLES R. CANTOR	48	(10)
Longevity Determinant Genes: What is the Evidence? What's the Importance? Panel Discussion.
By RICHARD CUTLER, Moderator: L.P. GUARANTE, THOMAS W. KENSLER, FRED NAFTOLIN, DEAN P. JONES, CHARLES R. CANTOR, GEORGE M. MARTIN, Panelists	58	(6)
Decoding the Pyramid: A Systems-Biological Approach to Nutrigenomics.
By JIM KAPUT	64	(16)
Effects of Testosterone on Cognitive and Brain Aging in Elderly Men.
By SCOTT D. MOFFAT	80	(13)
Oxidative Stress Profiling: Part I. Its Potential Importance in the Optimization of Human Health.
By RICHARD G. CUTLER	93	(43)
Oxidative Stress Profiling: Part II. Theory, Technology, and Practice.
By RICHARD G. CUTLER, JOHN PLUMMER, KAJAL CHOWDHURY, AND CHRISTOPHER HEWARD	136	(23)
Controversies in Dyslipidemias: Atheroprevention in Diabetes and Insulin Resistance.
By ELIOT A. BRINTON	159	(20)
Dietary Fat and Health: The Evidence and the Politics of Prevention: Careful Use of Dietary Fats Can Improve Life and Prevent Disease.
By WILLIAM E.M. LANDS	179	(14)
Physical Activity and Aging.
By KERRY J. STEWART	193	(14)
Would Doubling the Human Life Span Be a Net Positive or Negative for Us, Either as Individuals or as a Society? Point–Counterpoint.
By GREGORY B. STOCK AND DANIEL CALLAHAN	207	(12)
Abstracts Regulatory Mechanisms Controlling Gene Expression Mediated By the Antioxidant Response Element.
By THOMAS W. KENSLER	219	(1)
Targeting Redox Signaling Pathways for Anti-Inflammatory and Anti-Ischemic Drug Discovery.
By GUY MILLER	220	(1)
Mitochondrial Thioredoxin: Critical Protection for the Redox Throttle of Life
By DEAN P. JONES	221	(1)
Regulation of Aging By SIR2.
By LEONARD P. GUARANTE	222	(1)
Androgens in the Aging Man.
By WILLIAM J. BREMNER	223	(1)
Potential Adverse Effects of Administering Testosterone to Elderly Men.
By PETER J. SNYDER	224	(1)
Testosterone in Women.
By ADRIAN S. DOBS	225	(1)
Estrogen: Metabolism, Actions and Effects.
By JAMES W. SIMPKINS	226	(1)
Estrogen and the Heart: Choices for Prevention of Coronary Vascular Disease
By DAVID M. HERRINGTON	227	(1)
Estrogen, Cognition, and Dementia.
By SANJAY ASTHANA	228	(1)
Use of Growth Hormone for Prevention of Effects of Aging.
By S. MITCHELL HARMAN	229	(2)
Cardiovascular Risk Assessment.
By HARVEY S. HECHT	231	(2)
Index of Contributors	233