Lymphoid Organogenesis

by Melchers, F.; Compans, R. W.; Cooper, M.; Ito, Y.; Koprowski, H.; Oldstone, M.; Olsnes, S.

• ISBN13: 9783540675693
• ISBN10: 3540675698
• Format: Hardcover
• Copyright: 2000-11-01
• Publisher: Springer Verlag

Summary

It has been clear for a long time that after transplantation of a lymphoid organ, hematopoietic stem cells can regenerate the compartments of the organ, provided that the rest of its architecture - the strome, the epithelia and the vessels - is intact. Ahead lies the even greater challenge to assemble also these other architectural elements of a lymphoid organ by transplanting stem cells. The workshop on lymphoid organogenesis was convened to review current knowledge of and experimental skills involved in this grand project to build a lymphoid organ from its individual cellular components.

Table of Contents

List of Contributors	xi
I Stem Cells - Hematopoietic, Epithelial, Others
Human Mesenchymal Stem Cells: Progenitor Cells for Cartilage, Bone, Fat and Stroma	3	(10)
M.F. Pittenger
J.D. Mosca
K.R. McIntosh
Investigating the Genetic Control of Stem Cell Behavior	13	(8)
R.L. Phillips
Precursor B Cells from Pax-5-deficient Mice - Stem Cells for Macrophages, Granulocytes, Osteoclasts, Dendritic Cells, Natural Killer Cells, Thymocytes and T Cells	21	(6)
A.G. Rolink
F. Melchers
Insertional Mutagenesis as a Route to Identifying Genes Involved in Self Renewal of Haemopoietic Stem Cells	27	(8)
U. Just
D. Boettiger
O. Kan
T.M. Dexter
E. Spooncer
The Helix-Loop-Helix Inhibitor Id2 and Cell Differentiation Control	35	(8)
Y. Yokota
S. Mori
S.-I. Nishikawa
A. Mansouri
P. Gruss
T. Kusunoki
T. Katakai
A. Shimizu
Role of β1 Integrin for Hemato-Lymphopoiesis in Mouse Development	43	(8)
A.J. Potocnik
The Ikaros Family and the Development of Early Intraembryonic Hematopoietic Stem Cells	51	(8)
J. Liippo
K.-P. Nera
P. Kohonen
M. Lampisuo
K. Koskela
P. Nieminen
O. Lassila
Function of Cytokines in Lymphocyte Development	59	(8)
M. Kondo
I.L. Weissman
Re-evaluation of B Lymphocyte Lineage Differentiation Schemes	67	(8)
P.W. Kincade
K.J. Payne
K.-S. Tudor
Y. Yamashita
K.L. Medina
M.I.D. Rossi
T. Kouro
II Vessel Development
Growth Factors Regulating Lymphatic Vessels	75	(8)
A. Lymboussaki
M.G. Achen
S.A. Stacker
K. Alitalo
Hemangioblastic Precursors in the Avian Embryo	83	(8)
A. Eichmann
C. Corbel
L. Pardanaud
C. Breant
D. Moyon
L. Yuan
Cloning of JAM-2 and JAM-3: an Emerging Junctional Adhesion Molecular Family?	91	(10)
M.A. Aurrand-Lions
L. Duncan
L. Du Pasquier
B.A. Imhof
III Thymus Development
Thymus Epithelial Cell Reaggregate Grafts	101	(8)
H.-R. Rodewald
A Novel Anti-Ep-CAM Antibody to Analyze the Organization of Thymic Medulla in Autoimmunity	109	(10)
M. Naspetti
F. Martin
A. Biancotto
F. Malergue
P. Mansuelle
F. Galland
P. Naquet
Genetic Dissection of Thymus Development	119	(6)
M. Schorpp
W. Wiest
C. Egger
M. Hammerschmidt
T. Schlake
T. Boehm
Developing Thymocytes Organize Thymic Microenvironments	125	(8)
W. van Ewijk
H. Kawamoto
W.T.V. Germeraad
Y. Katsura
The Role of Mesenchyme in Thymus Development	133	(6)
J.J.T. Owen
D.E. McLoughlin
R.K. Suniara
E.J. Jenkinson
Making Central T-Cell Tolerance Efficient: Thymic Stromal Cells Sample Distinct Self-Antigen Pools	139	(10)
B. Kyewski
B. Rottinger
L. Klein
IV Lymphoid Tissue Development
T Cell Activation and Polarization by DCI and DC2	149	(12)
Y.-J. Liu
N. Kadowaki
M.-C. Rissoan
V. Soumelis
ILT Receptors at the Interface Between Lymphoid and Myeloid Cells	161	(6)
M. Cella
H. Nakajima
F. Facchetti
T. Hoffmann
M. Colonna
Functional Subsets of Memory T Cells Identified by CCR7 Expression	167	(6)
F. Sallusto
A. Langenkamp
J. Geginat
A. Lanzavecchia
Functional Organization of Secondary Lymphoid Organs by the Chemokine System	173	(8)
M. Lipp
R. Burgstahler
G. Muller
V. Pevzner
E. Kremmer
E. Wolf
R. Forster
The Cluster of ABCD Chemokines which Organizes T Cell-dependent B Cell Responses	181	(10)
C. Schaniel
F. Melchers
A.G. Rolink
Affinity Maturation in Ectopic Germinal Centers	191	(6)
B.A. de Boer
I. Voigt
H.-J. Kim
S.A. Camacho
M. Lipp
R. Forster
C. Berek
Precursors to Neonatal Lymph Nodes: LTβ+CD45+CD4+CD3-Cells are Found in Fetal Liver	197	(6)
R. Mebius
K. Akashi
The Role of Tumor Necrosis Factor and Lymphotoxin in Lymphoid Organ Development	203	(8)
R. Ettinger
Subject Index	211