Magnetic Resonance Spectroscopy in Multiple Sclerosis

by Filippi, Massimo

• ISBN13: 9788847001237
• ISBN10: 8847001234
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-03-01
• Publisher: SPRINGER

Summary

Recent years have witnessed dramatic advances in the development and use of magnetic resonance imaging (MRI) techniques that can provide quantitative measures with some degree of pathological specificity for the heterogeneous substrates of multiple sclerosis (MS). Magnetic resonance spectroscopy (MRS) is one of the most promising of these techniques. Thanks to MRS, axonal damage is no longer considered an end-stage phenomenon typical of only the most destructive lesions and the most unfortunate cases, but rather as a major component of the MS pathology of lesions and normal-appearing white matter at all the phases of the disease. This new concept is rapidly changing our understanding of MS pathophysiology and, as a consequence, the therapeutic strategies to modify the disease course favorably. Many of the authors have pionereed the use of MRS in MS, thus contributing to the foundation of the "axonal hypothesis".

Table of Contents

Introduction	1	(4)
M. Filippi
D.L. Arnold
G. Comi
Axonal Signals and Central Nervous System Myelination	5	(10)
C. Lubetzki
B. Zalc
Axonal Loss in Multiple Sclerosis	15	(18)
C. Bjartmar
B.D. Trapp
Magnetic Resonance Spectroscopy: Fundamentals	33	(18)
J.C. McGowan
Magnetic Resonance Spectroscopy in Experimental Allergic Encephalomyelitis	51	(10)
S.P. Morrissey
Axonal Injury and Disability in Multiple Sclerosis: Magnetic Resonance Spectroscopy as a Measure of Dynamic Pathological Change in White Matter	61	(8)
D.L. Arnold
N. De Stefano
S. Narayanan
P. M. Matthews
Functional Magnetic Resonance Imaging and Multiple Sclerosis: Cortical Reorganisation and Recovery	69	(10)
H. Reddy
D.L. Arnold
P.M. Matthews
Correlations between Magnetic Resonance Spectroscopy and Other Magnetic Resonance Parameters in Multiple Sclerosis	79	(8)
M. Rovaris
M. Filippi
Magnetization Transfer and Diffusion-Weighted Magnetic Resonance Imaging in Multiple Sclerosis and Other in White Matter Diseases	87	(10)
M. Filippi
G. Comi
New Magnetic Resonance Spectroscopy Strategies	97	(16)
O. Gonen
R.I. Grossman
Optimization and Standardization of Magnetic Resonance Spectroscopy Techniques for Multicenter Longitudinal Multiple Sclerosis Studies	113	(8)
J.C. McGowan
Overview of Magnetic Resonance Spectroscopy Studies in White Matter Diseases Other than Multiple Sclerosis	121	(14)
N. De Stefano
A. Federico
Overview of Magnetic Resonance Studies in Other Neurological Conditions	135	(14)
A. Falini
Subject Index	149