Magnetic Source Imaging of the Human Brain

by Lu, Zhong-Lin; Kaufman, Lloyd; Acar, Can E.; Buchanan, D.S.

• ISBN13: 9780805845129
• ISBN10: 0805845127
• Format: Paperback
• Copyright: 2003-06-01
• Publisher: Lawrence Erlbau

Summary

This book is designed to acquaint serious students, scientists, and clinicians with magnetic source imaging (MSI)--a brain imaging technique of proven importance that promises even more important advances. The technique permits spatial resolution of neural events on a scale measured in millimeters and temporal resolution measured in milliseconds. Although widely mentioned in literature dealing with cognitive neuroscience and functional brain imaging, there is no single book describing both the foundations and actual methods of magnetoencephalopgraphy and its underlying science, neuromagnetism. This volume fills a long-standing need, as it is accessible to scientists and students having no special background in the field, and makes it possible for them to understand this literature and undertake their own research. A self-contained unit, this book covers MSI from beginning to end, including its relationship to allied technologies, such as electroencephalography and modern functional imaging modalities. In addition, the book: *introduces the field to the non-specialist, providing a framework for the rest of the book; *provides a thorough review of the physiological basis of MSI; *describes the mathematical bases of MSI--the forward and inverse problems; *outlines new signal processing methods that extract information from single-trial MEG; *depicts the early, as well as the most recent versions of MSI technology; *compares MSI with other imaging methodologies; *describes new paradigms and analysis techniques in applying MSI to study human perception and cognition, which are also applicable to EEG; and *reviews some of the most important results in MSI from the most prominent researchers and laboratories around the world.

Table of Contents

Preface	ix
1 Basics of Neuromagnetism and Magnetic Source Imaging	1	(42)
Lloyd Kaufman and Zhong-Lin Lu
2 Toward Understanding the Physiological Origins of Neuromagnetic Signals	43	(34)
Yoshio Okada
3 Forward Problem Solution of Magnetic Source Imaging	77	(24)
N. G. Gençer, C. F. Acar, and I. O. Tamer
4 Magnetic Source Imaging: Search for Inverse Solutions	101	(34)
Jia-Zhu Wang and Lloyd Kaufman
5 Techniques for Investigating and Exploiting Nonlinearities in Brain Processes by Recording Responses Evoked by Sensory Stimuli	135	(24)
M. P. Regan and D. Regan
6 Independent Components of Magnetoencephalography: Localization and Single-Trial Response Onset Detection	159	(44)
Akaysha C. Tang and Barak A. Pearlmutter
7 Toward Noise-Immune Magnetoencephalography Instrumentation	203	(14)
J. Vrba, S. E. Robinson, and A. A. Fife
8 Full-Sensitivity Biomagnetometers: Sam Williamson's Vision Brought to Life	217	(14)
R. T. Johnson, E. C. Hirschkoff, and D. S. Buchanan
9 From 1- to 306-Channel Magnetoencephalography in 15 Years: Highlights of Neuromagnetic Brain Research in Finland	231	(12)
Olli V. Lounasmaa and Riitta Hari
10 Magnetoencephalography: From Pioneering Studies to Functional Brain Imaging	243	(16)
Cosimo Del Gratta and Gian Luca Romani
11 Optical Imaging of Brain Function and the Relation Between Neuronal Activity and Hemodynamics in Health and Disease	259	(22)
Edward L. Maclin
12 High-Frequency Oscillations From the Human Somatosensory Cortex: The Interneuron Hypothesis	281	(62)
Isao Hashimoto
13 Measuring Sensory Memory: Magnetoencephalography Habituation and Psychophysics
Zhong-Lin Lu and George Sperling
14 Clinical Applications of Brain Magnetic Source Imaging	343	(22)
Juergen B. Vieth, Helmut Kober, Oliver Ganslandt, Martin Möller, and Kyousuke Kamada
Epilogue: Samuel J. Williamson	365	(12)
Peter Levy and Lloyd Kaufman
Author Index	377	(16)
Subject Index	393