The MAK Collection for Occupational Health and Safety: Part IV: Biomonitoring Methods, Volume 11

by Editor: Jü; rgen Angerer (Institute for Occupational, Social, and Environmental Medicine, University of Erlangen, Germany); Editor: Helmut Greim (Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area)

• ISBN13: 9783527315963
• ISBN10: 3527315969
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-01-01
• Publisher: Vch Verlagsgesellschaft Mbh

Summary

Detailed, ready-to-use protocols for human biomonitoring methods, are provided here, which were developed to monitor concentrations of occupational toxicants, yet can be equally used for environmental monitoring. Examples are new methods for the determination of organophosphates or musk compounds in blood. All the methods are reliable, reproducible, adhere to 'Good Laboratory Practice' standards and cover all the required steps from sampling to the interpretation of results with respect to relevant biological exposure values. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors.

Author Biography

Jürgen Angerer is Head of the working group "Analytical Chemistry" of the Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. He is a member of the International Society of Exposure Analysis (ISEA) and board member of the International Society of Environmental Medicine (ISEM). He is author and editor of numerous books and belongs to the editorial boards of the Journal of Chromatography B as well as of the International Journal of Hygiene and Environmental Health.

Helmut Greim is Head of the Scientific Committee for Occupational Exposure Limits (SCOEL), which is working for the European Commission, and the former Head of the DFG-Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area.

Table of Contents

Contents of Volumes 1–11

Working Group Analytical Chemistry of the Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area

Organization – Objectives and operational procedure – Development, examination, release and quality of the analytical methods – Publications of the working group – Withdrawal of methods

Terms and symbols used

Terminology – symbols

Preliminary Remarks

The use of liquid chromatography/mass spectrometry (LC/MS) in biological monitoring

Methods

Bisphenol A in urine

Di(2-ethylhexyl) phthalate (DEHP) metabolites (2-ethyl-5-hydroxyhexyl phthalate, 2-ethyl-5-oxohexyl phthalate, mono(2-ethylhexyl) phthalate) in urine

5-Hydroxy-N-methyl-2-pyrrolidone (5-HNMP) and 2-hydroxy-N-methylsuccinimide (2-HMSI) in urine as metabolites of N-methyl-2-pyrrolidone (NMP)

Iridium in urine; addendum to "platinum and gold"

Monohydroxybutenylmercapturic acid (MHBMA) and dihydroxybutylmercapturic acid (DHBMA) in urine as metabolites of 1,3-butadiene

Neuropathy target esterase (NTE) in leukocytes

Organophosphates (chlorpyrifos, diazinon, fenitrothion, fenthion, malathion) in whole blood

Palladium in urine

Polycyclic musk compounds (PMC) in blood (1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethy lcyclopenta[g]-2-benzopyrane (HHCB), 7-acetyl-1,1,3,4,4,6-hexamethyltetrahydro naphthalene (AHTN), 4-acetyl-1,1-dimethyl-6-tert-butylindane (ADBI) and 6-acetyl-1,1,2,3,3,5-hexamethylindane (AHDI))

Propylene and diethylene glycol ethers in urine and blood (1-butoxypropanol-2, diethylene glycol dibutyl ether, diethylene glycol diethyl ether, diethylene glycol dimethyl ether, diethylene glycol monobutyl ether, diethylene glycol monobutyl ether actetate, diethylene glycol monoethyl ether, diethylene glycol monoethyl ether acetate, diethylene glycol monomethyl ether, dipropylene glycol monomethyl ether, 1-ethoxypropanol-2, 3-ethoxypropanol-1, 1-ethoxypropyl acetate-2, 1-methoxypropanol-2, 1-methoxypropanone-2, 1-methoxypropyl acetate-2, propylene glycol diacetate)

2,3,7,8-Tetrachlorodibenzo-p-dioxin in blood

Members and Guests of the Working Subgroup Analyses of Hazardous Substances in Biological Materials of the Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area

Substance.

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