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Building on the success of the previous edition, this extremely thorough revision:
In 44 chapters organized into six major sections, the book covers the full range of liver tumors. The perfect blend of evidence and experience, Malignant Liver Tumors: Current and Emerging Therapies, 3rd Edition, illuminates the path to better patient care.
Associate Editors:Tadatoshi Takayama, Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan
CM Lo, Liver Transplant Centre, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
R. Chari, Associate Professor of Surgery and Cancer Biology, Division Chief of Hepatobillary Surgery and Liver Transplantation, Staff Surgeon, Veterans Affairs Medical Center, Vanderbilt University Medical Center, Nashville, USA
M. Morse, Associate Professor, Duke University Medical School, Durham, USA
J. Llovet, Barcelona-Clínic Liver Cancer Group, Liver Unit, Institut d'Investigacions Biomédiques August Pi I Sunyer, Hospital Clínic, University of Barcelona, Catalonia, Spain
Preface, xi
Acknowledgments, xiii
Abbreviations, xiv
Section 1 Introduction, 1
1 From Promethean to Modern Times, 3Kuno Lehmann, Stefan Breitenstein, and Pierre-Alain Clavien
2 Hepatic Anatomy and Terminology, 11Steven M. Strasberg
Section 2 Epidemiology and Diagnosis, 27
Introduction, 29Chung-Mau Lo
3 Histology and Pathology of Normal and Diseased Liver, 30Valérie Paradis and Achim Weber
4 Pathology of Primary and Secondary Malignant Liver Tumors, 40Kay Washington
5 Epidemiology, Etiology, and Natural History of Hepatocellular Carcinoma, 52Wei-Chen Lee and Miin-Fu Chen
6 Epidemiology, Etiology, and Natural History of Cholangiocarcinoma, 56Peter Neuhaus, Ulf P. Neumann, and Daniel Seehofer
7 Epidemiology, Etiology, and Natural History of Colorectal Liver Metastases, 64Robert J. Porte
8 Tumor Markers in Primary and Secondary Liver Tumors, 69Ketsia B. Pierre and Ravi S. Chari
9 Modalities for Imaging Liver Tumors, 76Dominik Weishaupt and Thomas F. Hany
Section 3 Systemic and Regional Therapies, 103
Introduction, 105Ravi S. Chari
10 Systemic Treatment of Hepatobiliary Tumors, 107Panagiotis Samaras, Michael A. Morse, and Bernhard C. Pestalozzi
11 External Beam Radiation Therapy for Liver Tumors, 122Rakesh Reddy and A. Bapsi Chakravarthy
12 Internal Radiation Therapy for Liver Tumors, 131Ahsun Riaz, Laura Kulik, Michael Abecassis, and Riad Salem
13 Transarterial Embolization for Patients with Hepatocellular Carcinoma, 139Jordi Bruix, Carmen Ayuso, and Maria I. Real
14 Selective Continuous Intra-arterial Chemotherapy for Liver Tumors, 151Fidel D. Huitzil-Melendez, Stefan Breitenstein, and Nancy Kemeny
15 Isolated Hepatic Perfusion and Percutaneous Hepatic Perfusion, 164Charles K. Heller, III, James F. Pingpank, and Steven K. Libutti
Section 4 Resection, Ablation or Transplantation for Liver Tumors, 173
Introduction, 175Jean-Nicolas Vauthey and Tadatoshi Takayama
16 Liver Resection of Primary Tumors: Hepatocellular Carcinoma, Cholangiocarcinoma, and Gallbladder Cancer, 177Tadatoshi Takayama and Masatoshi Makuuchi
17 Liver Resection of Colorectal Liver Metastases, 192Daria Zorzi, Yun Shin Chun, and Jean-Nicolas Vauthey
18 Laparoscopic Liver Resection, 203Luca Viganò and Daniel Cherqui
19 Repeat Resection for Liver Tumors, 216Mickael Lesurtel and Henrik Petrowsky
20 Cryoablation of Liver Tumors, 227Sivakumar Gananadha and David L. Morris
21 Thermal Ablation of Liver Tumors by Radiofrequency, Microwave, and Laser Therapy, 244M. B. Majella Doyle and David C. Linehan
22 Ethanol and Other Percutaneous Injection Modalities in the Treatment of Liver Tumors, 266Michael A. Heneghan and Andrew D. Yeoman
23 Transplantation for Liver Tumors, 281François Durand, Claire Francoz, and Jacques Belghiti
24 Preventing Recurrence of Hepatocellular Carcinoma after Curative Resection, 296Stefan Breitenstein, Dimitris Dimitroulis, and Beat Müllhaupt
Section 5 Guidelines for Liver Tumor Treatment, 305
Introduction, 307Stefan Breitenstein and Pierre-Alain Clavien
25 Strategies for Safer Liver Surgery, 308Philipp Dutkowski, Olivier de Rougemont, and Pierre-Alain Clavien
26 Hepatocellular Carcinoma, 317Tadatoshi Takayama
27 Cholangiocarcinoma, 324Jacques Belghiti and Charles B. Rosen
28 Gallbladder Cancer, 333Juan Hepp and Chung-Mau Lo
29 Colorectal Liver Metastases, 342Phuong L. Doan, Jean-Nicolas Vauthey, Martin Palavecino, and Michael A. Morse
Section 6 Emerging Therapies, 347
Introduction, 349Michael A. Morse and Josep M. Llovet
30 Viral-Based Therapies for Primary and Secondary Liver Cancer, 352Menghua Dai, Lorena Gonzalez, and Yuman Fong
31 Signaling Pathways and Rationale for Molecular Therapies in Hepatocellular Carcinoma, 368Augusto Villanueva, Clara Alsinet, and Josep M. Llovet
32 Novel Therapies Targeted at Signal Transduction in Liver Tumors, 382Fidel D. Huitzil-Melendez, Ghassan K. Abou-Alfa, and Michael A. Morse
33 Induction of Apoptosis in Liver Tumors, 393Markus Selzner and Pierre-Alain Clavien
34 Antiangiogenic Agents for Liver Tumors, 400Mathijs Vogten, Emile E. Voest, and Inne H.M. Borel Rinkes
35 Integrative Oncology: Alternative and Complementary Treatments, 414Barrie R. Cassileth and Jyothirmai Gubili
Section 7 Special Tumors, Population, and Special Considerations, 421
Introduction, 423Stefan Breitenstein and Pierre-Alain Clavien
36 Liver Metastases from Endocrine Tumors, 424Clayton D. Knox and C. Wright Pinson
37 Uncommon Primary and Metastatic Liver Tumors, 439Stefan Breitenstein, Ashraf Mohammad El-Badry, and Pierre-Alain Clavien
38 Liver Tumors in Special Populations, 454Tadahiro Uemura, Akhtar Khan, and Zakiyah Kadry
39 Malignant Liver Tumors in Children, 475Xavier Rogiers and Ruth De Bruyne
40 Liver Tumors in Asia, 487Norihiro Kokudo, Sumihito Tamura, and Masatoshi Makuuchi
41 Liver Tumors in South America, 500Lucas McCormack and Eduardo de Santibañes
42 Liver Tumors in Africa, 509Michael C. Kew
43 Anesthetic Management of Liver Surgery, 519Marco P. Zalunardo
44 Qualitative and Economic Aspects of Liver Surgery, 531René Vonlanthen, Ksenija Slankamenac, and Christian Ernst
Index, 539
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