Management of Acute Coronary Syndromes

by Cannon, Christopher P., M.D.; Braunwald, Eugene

• ISBN13: 9781588291301
• ISBN10: 1588291308
• Edition: 2nd
• Format: Hardcover
• Copyright: 2002-11-01
• Publisher: Humana Pr Inc

Summary

In this second edition of his highly acclaimed book, Christopher P. Cannon, MD, and a team of preeminent clinical investigators have thoroughly revised and expanded every chapter to reflect the recent explosion of clinical trials on the management of acute coronary syndromes (ACS). This includes: the newer tests, such as C reactive protein; a multimarker approach to diagnosis and risk stratification; new antiplatelet agents; and combinations of thrombolytic-antithrombotic regimens. Also discussed are the latest developments in interventional cardiology, the use of cost-effectiveness in clinical trials to choose appropriate therapies, and the employment of critical pathways analysis to improve compliance with evidence-based medicine and guideline recommendations.

Table of Contents

Foreword	v
Preface	vii
Contributors	xiii
Part I Pathophysiology
The Spectrum of Myocardial Ischemia: The Paradigm of Acute Coronary Syndromes	3	(16)
Christopher P. Cannon
Eugene Braunwald
Linking Biochemistry, Vascular Biology, and Clinical Events in Acute Coronary Syndromes	19	(42)
Richard C. Becker
Annemarie Armani
Triggers of Acute Coronary Syndromes	61	(34)
Peter M. Sapin
James E. Muller
Insights into the Pathophysiology of Acute Ischemia Syndromes Using the TIMI Flow Grade, TIMI Frame Count, and TIMI Myocardial Perfusion Grade	95	(26)
C. Michael Gibson
Sabina A. Murphy
Jeffrey J. Popma
Part II Diagnosis
Emergency Department Presentations of Acute Cardiac Ischemia	121	(36)
J. Hector Pope
Harry P. Selker
Early Identification and Treatment of Patients with Acute Coronary Syndromes	157	(26)
Mary M. Hand
Costas T. Lambrew
Serum Markers for Diagnosis and Risk Stratification in Acute Coronary Syndromes	183	(28)
L. Kristin Newby
W. Brian Gibler
Robert H. Christenson
E. Magnus Ohman
Technologies to Diagnose Acute Ischemia	211	(26)
Robert J. Zalenski
Joseph Lau
Harry P. Selker
Part III ST-Segment Elevation Myocardial Infarction
Thrombolytic Therapy	237	(44)
Jeffrey L. Anderson
James S. Zebrack
Primary Angioplasty	281	(34)
Sorin J. Brener
Eric J. Topol
Expanding the Access to Percutaneous Coronary Intervention for Patients Admitted to Community Hospitals	315	(18)
Thomas P. Wharton, Jr.
Nancy Sinclair McNamara
Antiplatelet and Anticoagulant Therapy	333	(44)
Marc S. Sabatine
Ik-Kyung Jang
β-Adrenergic Blockers, Calcium Channel Blockers, and Nitrates	377	(22)
Yerem Yeghiazarians
Peter H. Stone
Angiotensin Converting Enzyme Inhibitors After and During Acute Coronary Syndromes, and, in Particular, Myocardial Infarction	399	(26)
Rodolfo Carrillo-Jimenez
Charles H. Hennekens
Gervasio A. Lamas
Risk Stratification: Exercise Testing, Imaging, and Cardiac Catheterization	425	(34)
Sanjeev Puri
Hani A. Razek
Bernard R. Chaitman
Part IV Non-ST-Segment Elevation Myocardial Infarction
Anticoagulant therapies	459	(22)
Marc Cohen
Antiplatelet Therapy	481	(38)
Ian Conde-Pozzi
Neal S. Kleiman
Thrombolytics and Invasive vs Conservative Strategies in Unstable Angina	519	(16)
Ali Moustapha
H. Vernon Anderson
Current Device Strategies in the Management of Acute Coronary Syndromes	535	(34)
Kanwar P. Singh
C. Michael Gibson
Part V Special Aspects of Acute Coronary Syndromes
Women and Acute Coronary Syndromes	569	(34)
Jane A. Leopold
Alice K. Jacobs
The Modern Strategy for Cardiogenic Shock	603	(50)
Gary E. Lane
David R. Holmes, Jr.
Myocardial Infarction in the Younger Patient	653	(14)
James C. Fang
Jorge Plutzky
Cholesterol Lowering	667	(28)
Terje R. Pedersen
Serena Tonstad
``Secondary Prevention'' of Myocardial Infarction	695	(10)
Jorge Plutzky
Roger S. Blumenthal
Cost and Cost-Effectiveness in Acute Coronary Syndromes	705	(20)
William S. Weintraub
Smoking Cessation	725	(20)
Beth C. Bock
Bruce Becker
Critical Pathways for Acute Coronary Syndromes	745	(18)
Christopher P. Cannon
Patrick T. O'Gara
Index	763