Markers in Cardiology - AHA Current and Future Clinical Applications

by Adams, Jesse E.; Apple, Fred S.; Jaffe, Allan S.; Wu, Alan H. B

• ISBN13: 9780879934729
• ISBN10: 0879934727
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-05-18
• Publisher: Wiley-Blackwell

Summary

The chapters in this monograph detail the past, present and potential future of markers used for the detection of myocardial injury and for risk assessment as part of a cardiovascular disease work-up strategy. The strengths of this extensive overview, written by many of the current leaders in the field, lie in the evidence presented in addressing analytical/technical, clinical, and outcome-assessments of each biomarker currently used in clinical practice, and for those being investigated as potential cutting-edge tools.

Author Biography

Jesse E. Adams III, MD, FACC Investigator, Jewish Hospital Heart and Lung Institute; Assistant Clinical Professor of Medicine, Division of Cardiology, University of Louisville, KY Fred S. Apple, PhD Medical Director, Clinical Laboratories, Hennepin County Medical Center; Professor of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis Stephanie W. Bateman, BA Research Assistant, Dartmouth Medical School, Lebanon, NH Linda Cise, MS Research Technician, Roudebush VAMC, Indianapolis, IN Desire Collen, MD, PhD Professor of Medicine, Director of the Center for Molecular and Vascular Biology and Department of Cardiology, University of Leuven, Belgium George K. Daniel, MD Cardiology Fellow, Krannert Institute of Cardiology, Indiana University School of Medicine and Roudebush VAMC, Indianapolis, IN Rose Felten, MS Research Technician, Krannert Institute of Cardiology, Indiana University School of Medicine and Roudebush VAMC, Indianapolis, IN V.J. Ferrans, MD, PhD Pathology Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD George A. Fischer, PhD, DABCC Technical Director, Chemistry, Brigham and Women's Hospital, Boston, MA Norbert Frey, MD Medizinische Klinik II, Medizinische, Universitat zu Lubeck, Germany Robert Fromm, MD, MPH Associate Professor of Medicine, Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX Evangelos Giannitsis, MD Medizinische Klinik II, Medizinische, Universitat zu Lubeck, Germany W. Brian Gibler, MD Richard C. Levy Professor of Emergency Medicine and Chair of the Department of Emergency Medicine, University of Cincinnati College of Medicine; Director of Center for Emergency Care, University of Cincinnati Hospital, OH Jessica Gillespie, BS Krannert Institute of Cardiology, Indiana University School of Medicine and Roudebush VAMC, Indianapolis Jan F.C. Glatz, PhD Associate Professor of Physiology, Cardiovascular Research Institute Maastricht (CARIM); Department of Physiology, Maastricht University, The Netherlands Britta U. Goldmann, MD Cardiology Department, University Hospital Eppendorf, Hamburg, Germany David A. Grundy, MD Emergency Medicine Training Program, Department of Emergency Medicine, University of Cincinnati College of Medicine, OH Richa Gupta, MD Postdoctoral Fellow, Krannert Institute of Cardiology, Indiana University School of Medicine and Roudebush VAMC, Indianapolis, IN Eugene H. Herman, PhD Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Laurel, MD Wim T. Hermens, PhD Cardiovascular Research Institute Maastricht (CARIM); Professor of Molecular Biophysics, Maastricht University, The Netherlands Paul Holvoet, PhD Centre for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium Michael P. Hudson, MD Duke Clinical Research Institute, Durham, NC Allan S. Jaffe, MD Senior Assistant Consultant, Mayo Clinic; Professor of Medicine, Cardiovascular Division, Mayo Medical School, Rochester, MN Robert L. Jesse, MD, PhD Associate Professor, Internal Medicine/Cardiology, Director, Acute Cardiac Care, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond Saeed A. Jortani, PhD, FACB Senior Research Associate, Director, Diagnostic Reference Laboratory, Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, KY Hugo A. Katus, MD Medizinische Klinik II, Medizinische, Universitat zu Lubeck, Germany Michael C. Kontos, MD Assistant Professor, Internal Medicine/Cardiology, Associate Director, Acute Cardiac Care, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond Ralf Labugger, MSc PhD Candidate, Department of Physiology, Queen's University, Kingston, Ontario, Canada Johannes Mair, MD Associate Professor of Clinical Chemistry and Laboratory Medicine, University of Innsbruck; Specialist in Clinical Chemistry and Laboratory Medicine, Resident in Internal Medicine and Cardiology, Department of Internal Medicine, Division of Cardiology, University Hospital of Innsbruck, Austria Jason L. McDonough, BSc(H) PhD Candidate, Department of Physiology, Queen's University, Kingston, Ontario, Canada Vickie A. Miracle, RN, EdD, CCRN, CCNS Director of Education, Jewish Hospital Heart and Lung Institute, Louisville, KY Margit Muller-Bardorff, MD Medizinische Klinik II, Medizinische, Universitat zu Lubeck, Germany E. Magnus Ohman, MD Duke Clinical Research Institute, Durham, NC Kelly S. Quinn-Hall, MT (ASCP) Technical Specialist, Dartmouth-Hitchcock Medical Center, Lebanon, NH Paul M. Ridker, MD, MPH, FACC Associate Professor of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA Michael E. Ritchie, MD Associate Professor of Medicine, Krannert Institute of Cardiology, Indiana University School of Medicine; Chief, Section of Cardiology, Roudebush VAMC, Indianapolis Robert Roberts, MD Don W. Chapman Professor of Medicine, Professor of Medicine and Cell Biology, Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX Kathy Sturdevant, BS Research Technician, Roudebush VAMC, Indianapolis, IN Roland Valdes, Jr., PhD, FACB Professor and Vice-Chairman, Director, Clinical Chemistry and Toxicology, Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, KY Frans Van de Werf, MD, PhD Professor of Medicine, Head of the Department of Cardiology, University of Leuven, Belgium Jennifer E. Van Eyk, PhD Assistant Professor, Department of Physiology, Queen's University, Kingston, Ontario, Canada Johan Vanhaecke, MD, PhD Professor of Medicine, Head of Heart Failure/Heart Transplantation Unit, Department of Cardiology, University of Leuven, Belgium Britta Weidtmann, MD Medizinische Klinik II, Medizinische, Universitat zu Lubeck, Germany Stacey Wieczorek, PhD Postdoctoral Fellow, Hartford Hospital, CT Alan H.B. Wu, PhD Professor, Department of Pathology and Laboratory Medicine, Hartford Hospital, CT Kiang-Teck J. Yeo, PhD Associate Professor, Dartmouth Medical School and Dartmouth-Hitchcock Medical Center, Lebanon, NH

Table of Contents

Preface	v
Acknowledgments	vii
Contributors	ix
Analytical Issues Affecting the Clinical Performance of Cardiac Troponin Assays	1	(12)
Alan H.B. Wu
Prepare To Meet Your Markers: Making the Most out of Troponin I Degradation	13	(10)
Jason L. McDonough
Ralf Labugger
Jennifer E. Van Eyk
Functional Sensitivity of Cardiac Troponin Assays and its Implications for Risk Stratification for Patients with Acute Coronary Syndromes	23	(8)
Kiang-Teck J. Yeo
Kelly S. Quinn-Hall
Stephanie W. Bateman
George A. Fischer
Stacey Wieczorek
Alan H.B. Wu
Report on a Survey of Analytical and Clinical Characteristics of Commercial Cardiac Troponin Assays	31	(4)
Fred S. Apple
Jesse E. Adams, III
Alan H.B. Wu
Allan S. Jaffe
The Current Assessment of Qualitative and Quantitative Point-of-Care Testing of Cardiac Markers	35	(12)
Roland Valdes, Jr.
Saeed A. Jortani
Acute Coronary Syndromes: Pathophysiology, Clinical Presentation, and Initial Diagnostic Strategies	47	(16)
Jesse E. Adams, III
Vickie A. Miracle
WHO Criteria: Where Do We Go from Here?	63	(12)
Allan S. Jaffe
An Integrated Diagnostic Approach to the Patient with Chest Pain	75	(20)
Robert L. Jesse
Michael C. Kontos
The Use of Cardiac Markers for Therapeutic Decisions in Acute Coronary Syndromes	95	(10)
Michael P. Hudson
Britta U. Goldmann
E. Magnus Ohman
The Evaluation of Acute Coronary Syndrome in the Emergency Department: The Impact of Cardiac Biomarkers and ST-Segment Trend Monitoring	105	(12)
David A. Grundy
W. Brian Gibler
Cardiac Troponin T in Coronary Artery Disease: Where Do We Stand?	117	(14)
Evangelos Giannitsis
Britta Weidtmann
Margit Muller-Bardorff
Norbert Frey
Hugo A. Katus
Creatine Kinase: A Marker for the Early Diagnosis of Acute Myocardial Infarction	131	(8)
Robert Fromm
Robert Roberts
Fatty Acid Binding Protein as a Plasma Marker for the Early Assessment of Individuals with Acute Coronary Syndromes	139	(20)
Jan F.C. Glatz
Wim T. Hermens
Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein: Markers of Coronary Artery Disease	159	(14)
Paul Holvoet
Frans Van de Werf
Johan Vanhaecke
Desire Collen
High-Sensitivity C-Reactive Protein: A Novel Inflammatory Marker for Predicting the Risk of Coronary Artery Disease	173	(12)
Paul M. Ridker
Nuclear Factor Kappa B: A Marker of Coronary Artery Disease Activity?	185	(8)
George K. Daniel
Richa Gupta
Jessica Gillespie
Rose Felten
Linda Cise
Kathy Sturdevant
Michael E. Ritchie
The Use of Troponins to Detect Cardiac Injury after Cardiac and Noncardiac Surgery	193	(10)
Jesse E. Adams, III
The Role of Cardiac Troponin Testing in Renal Disease	203	(8)
Fred S. Apple
The Use of Cardiac Biomarkers for the Detection of Drug-Induced Myocardial Damage	211	(24)
Eugene H. Herman
V.J. Ferrans
The Utility of Brain Natriuretic Peptides in Patients with Heart Failure and Coronary Artery Disease	235	(28)
Johannes Mair
Index	263