Mechanisms of B Cell Neoplasia 1998 15th Workshop

by Melchers, F.

• ISBN13: 9783540657590
• ISBN10: 3540657592
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-06-01
• Publisher: Springer Verlag

Summary

Proceedings of the Workshop held at the Basel Institute for Immunology on the 4th -6th October 1998.

Table of Contents

List of Contributors	p. XIII
Speakers at the B Cell Neoplasia Workshop 1998	p. XVII
B Cell and Plasma Cell Development
The Formation and Selection of Cells Expressing PreB Cell Receptors and B Cell Receptors	p. 3
Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development	p. 11
Negative Selection of Self-reactive B Lymphocytes Involves Complement	p. 21
Cross-talk Between CD44 and c-Met in B Cells	p. 31
The Transition from Immature to Mature B Cells	p. 39
CD2lhigh IgMhigh Splenic B Cells Enriched in the Marginal Zone: Distinct Phenotypes and Functions	p. 45
Do Germinal Centers Have a Role in the Generation of Lymphomas?	p. 53
Role of Complement Receptors CD2I/CD35 in B Lymphocyte Activation and Survival	p. 63
Long-lived Plasma Cells Survive Independent of Antigen	p. 71
Chemokines and Chemokine Receptors
Regulation of Expression of Chemokine Receptor BLR1/CXCR5 during B Cell Maturation	p. 79
Chemokines and B cell Homing to Follicles	p. 87
A Novel CC Chemokine ABCD-1, Produced by Dendritic Cells and Activated B Cells, Exclusively Attracts Activated T Lymphocytes	p. 95
Human Macrophage-Derived Chemokine (MDC) is Strongly Expressed Following Activation of both Normal and Malignant Precursor and Mature B Cells	p. 103
Susceptibility Genes for AIDS and AIDS-Related Lymphoma	p. 111
Molecular Mechanisms of T Helper Cell Differentiation and Tissue-specific Migration	p. 117
The Role of Chemokine Receptors in Directing Traffic of Naive, Type I and Type 2 T Cells	p. 123
A Lymphoid Tissue-Specific Receptor, EDG6, with Potential Immune Modulatory Functions Mediated by Extracellular Lysophospholipids	p. 131
Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations
Phenotypic and Molecular Characterization of Human Peripheral Blood B-Cell Subsets with Special Reference to N-Region Addition and J¿-Usage in V¿J¿-Joints and ¿/¿-Ratios in Naive Versus Memory B-Cell Subsets to Identify Traces of Receptor Editing Processes	p. 141
Tuning Somatic Hypermutation by Transcription	p. 149
Immunoglobulin Gene Associated Chromosomal Translocations in B Cell Derived Tumors	p. 161
Analysis of B-cell Neoplasias by Spectral Karyotyping (SKY)	p. 169
Recurrent Non-reciprocal Translocations of Chromosome 5 in Primary T(12;15)-positive BALB/c Plasmacytomas	p. 175
MYC-Induced Cyclin D2 Genomic Instability in Murine B Cell Neoplasms	p. 183
The Role of Somatic Hypermutation in the Generation of Deletions and Duplications in Human Ig V Region Genes and Chromosomal Translocations	p. 193
Chromosome 13 Deletion in Myeloma	p. 199
Unusual Immunoglobulin and T-Cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias	p. 205
Analysis of Variable Heavy and Light Chain Genes in Follicular Lymphomas of Different Heavy Chain Isotype	p. 217
Regulation of c-myc and Immunoglobulin ¿ Gene Transcription by Promoter-proximal Pausing of RNA Polymerase II	p. 225
Biology of Lymphomagenesis, B-CLL, Autoimmunity
Epidemiology of B-Cell Lymphomas	p. 235
Alternative Splicing of CD79a (Ig¿) and CD79b (Igß) Transcripts in Human B-CLL Cells	p. 241
Novel Aspects of Murine B Cell Lymphomas	p. 249
Molecular Pathogenesis of B Cell Malignancy: The Role of BCL-6	p. 257
ATM and Lymphoid Malignancies; Use of Oriented Peptide Libraries to Identify Novel Substrates of ATM Critical in Downstream Signaling Pathways	p. 267
MHC-linked Control of Murine SLE	p. 275
The Adaptor Protein SLP-65/BLNK Controls the Calcium Response in Activated B Cells	p. 283
Involvement of the SHP-1 Tyrosine Phosphatase in Regulating B Lymphocyte Antigen Receptor Signaling, Proliferation and Transformation	p. 291
Antigen Receptor Signaling Induces Differential Tyrosine Kinase Activation and Population Stability in B-Cell Lymphoma	p. 299
Importance of CD44 Variant Isoforms in Mouse Models for Inflammatory Bowel Disease	p. 307
EBNA2 and c-myc in B Cell Immortalization by Epstein-Barr Virus and in the Pathogenesis of Burkirt's Lymphoma	p. 315
Myeloma, Plasmacytomas and Related Subjects
The Control of Proliferation, Survival and Apoptosis in Human Multiple Myeloma Cells in vitro	p. 325
Activation Molecules on Human Myeloma Cells	p. 335
Peritoneal B-1 Cells Switch in vivo to IgA and these IgA Antibodies can bind to Bacteria of the Normal Intestinal Microflora	p. 343
Inhibition of Pristane-Induced Peritoneal Plasmacytoma Formation	p. 351
The Role of pl6INK4a (Cdkn2a) in Mouse Plasma Cell Tumors	p. 363
Transgenic Shuttle Vector Assays for Assessing Oxidative B-cell Mutagenesis in vivo	p. 369
Plasmacytoma Induction in Specific Pathogen-Free (SPF) bcl-2 Transgenic BALB/c Mice	p. 379
Induction of B Cell Autoimmunity by Pristane	p. 387
Cytokine Network Imbalances in Plasmacytoma-Regressor Mice	p. 395
The Role of Human Herpesvirus-8, (HHV-8), in Multiple Myeloma Pathogenesis	p. 403
Subject Index	p. 411
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