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9780521071833

Mechanisms in Blood Coagulation, Fibrinolysis and the Complement System

by
  • ISBN13:

    9780521071833

  • ISBN10:

    0521071836

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2008-08-14
  • Publisher: Cambridge University Press

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Summary

This book provides a comprehensive account of the proteins involved in blood coagulation, fibrinolysis and the complement system. A major section of the book is devoted to each of these three systems, with separate chapters dealing in detail with structural aspects and different functional processes. Topics covered in the blood coagulation section include the activation of factors IX and X and prothrombin, and the formation and stabilisation of fibrin. The fibrinolysis section includes the activation of plasminogen, the degradation of fibrin and the regulation of fibrinolysis. The complement system itself is covered in chapters dealing with classical activation, alternative activation, the lytic complex and the regulatory processes involved. In addition, one section deals with special topics, including the kinin system, signal peptides, haemostasis, and the evolution of protein structure. This volume will be of use to researchers and advanced students in the fields of haematology, immunology and clinical chemistry.

Table of Contents

Foreword
Introduction
Blood Coagulation
The coagulation process: an Introduction
Contact activation
Activation of factor IX
Activation of factor X in the intrinsic pathway
Activation of prothrombin
Activations in the extrinsic pathway
Formation and stabilisation of fibrin
Regulation of blood coagulation
Fibrinolysis
Complements of the fibrinolytic system
Mechanisms of fibrinolysis
The Complement System
Overview of the complement system
Classical activation of the complement system
Alternative activation of the complement system
The lytic complex (MAC)
Regulation processes in the complement system
Anaphylatoxin inactivator
Complement reactors
Special Topics
The kinin system
Glycosylation
Signal peptides
Modification of amino-acid residues
Coagulation-active surfaces in vivo
The binding of proteins to coagulation-active surfaces
Haemostasis
Integrins
Serpins
Some evolutionary considerations
Appendix
References
Index
Table of Contents provided by Publisher. All Rights Reserved.

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