Mechanisms and Mediators of Neuropathic Pain

by Malmberg, Annika B.; Chaplan, Sandra R.

• ISBN13: 9783764362379
• ISBN10: 3764362375
• Format: Hardcover
• Copyright: 2002-06-01
• Publisher: Birkhauser

Summary

Numerous improvements in our understanding of the mechanisms thatunderlie neuropathic pain states have come from the development ofanimal models, most of which involve partial peripheral nerve injury.The animal models have shown that nerve injury initiates a cascade ofevents resulting in altered neurochemistry and molecular biology of theperipheral neurons, the dorsal root ganglion cell, and changes inneurotransmitter and receptor expression in the dorsal horn of thespinal cord. Moreover, nerve injury produces anatomical changes withfunctional consequences.This volume summarises the current understanding of thepathophysiological processes in the peripheral and central nervoussystem that contribute to the neuropathic pain. It provides a timelyreview of neuropathic pain mechanisms, written by experts in the field.The book focuses on peripheral consequences of nerve injury, spinal cordplasticity following peripheral nerve injury, preclinical and clinicalparadigms, and new treatment strategie

Table of Contents

List of contributors	vii
Preface	xi
Peripheral consequences of nerve injury
Electrophysiological characteristics of injured peripheral nerves	3	(20)
Martin Michaelis
Sodium channels and the molecular basis for pain	23	(28)
Joel A. Black
Theodore R. Cummins
Sulayman D. Dib-Hajj
Stephen G. Waxman
Changes in DRG neurons after injury: possible involvement in the development and maintenance of neuropathic pain	51	(16)
Valerie M.K. Verge
Tracy D. Wilson-Gerwing
Laurie A. Karchewski
Kelly A. Gratto
Neuroinflammation, cytokines and neuropathic pain	67	(12)
Linda S. Sorkin
Spinal cord plasticity following peripheral nerve injury
Pharmacological plasticity associated with neuropathic pain states	79	(10)
Victoria Chapman
Anthony H. Dickenson
Sprouting and reorganization in the spinal cord after nerve injury	89	(20)
Susan M. Carlton
Richard E. Coggeshall
Neuropathic pain: preclinical and clinical paradigms
Pre-clinical nerve ligation models: behavior and electrophysiology	109	(18)
Jin Mo Chung
Kyungsoon Chung
Animal models of toxic and metabolic sensory neuropathies	127	(26)
Nigel A. Calcutt
Jason D. Freshwater
Role of adrenergic transmitters and receptors in nerve and tissue injury related pain	153	(22)
Ralf Baron
Srinivasa N. Raja
Evaluation of neuropathic pain	175	(26)
Karen M. Park
Richard H. Gracely
New treatment strategies for neuropathic pain
Glutamate receptor antagonists and neuropathic pain	201	(10)
Per Kristian Eide
Antiepileptic drugs for treatment of neuropathic pain	211	(22)
Charles P. Taylor
Calcium channel antagonists for the treatment of pain	233	(12)
Mark S. Wallace
Cholinergic, adenosinergic and α2 adrenergic mechanisms in chronic neuropathic pain	245	(10)
Hartmut Buerkle
Stuart A. Dunbar
Index	255