Mechanisms of Sepsis-induced Organ Dysfunction And Recovery

by Abraham, E.; Singer, M.

• ISBN13: 9783540301578
• ISBN10: 3540301577
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-01-30
• Publisher: Springer Verlag

Summary

There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.

Table of Contents

Setting the Scene	p. 1
The InflammatoryResponse Genetics and Severe Sepsis	p. 17
Cell Signaling Pathways of the Innate Immune System During Acute Inflammation	p. 35
Early-Onset Pro-inflammatory Cytokines	p. 55
The Significance of HMGB1, a Late-Acting Pro-inflammatory Cytokine	p. 67
Nitric Oxide	p. 77
Involvement of Reactive Oxygen and Nitrogen Species in the Pathogenesis of Acute Lung Injury	p. 97
Heat Shock Proteins in Inflammation	p. 113
Fibrosis in the Acute Respiratory Distress Syndrome	p. 123
Resolution of Inflammation	p. 137
The Cellular Immune Respone
Compartmentalized Activation of Immune Cells During Sepsis and Organ Dysfunction	p. 161
The Neutrophil in the Pathogenesis of Multiple Organ Dysfunction Syndrome	p. 183
The Role of the Macrophage	p. 203
The Role of the Endothelium	p. 211
Differential Effects of Pro-Inflammatory Mediators on Alveolar Epithelial Barrier Function	p. 229
Mechanisms and Pathways of Dysfunction
Macrocirculatory Disturbances	p. 239
The Microcirculation Is a Vulnerable Organ in Sepsis	p. 249
The Cholinergic Anti-inflammatory Pathway: Connecting the Mind and Body	p. 263
Coagulation in Sepsis	p. 273
The Role of Insulin and Blood Glucose Control	p. 287
Dysfunction of the Bioenergetic Pathway	p. 299
Metabolic Pathways	p. 311
Cell Death and Acute Lung Injury	p. 321
Mechanisms of Immunodepression after Central Nervous System Injury	p. 335
Organ-specific Mechanisms of Dysfunction
Pulmonary Dysfunction	p. 353
The Gut	p. 369
Endogenous Danger Signals in Liver Injury: Role of High Mobility Group Box Protein-1	p. 383
Sepsis-induced Acute Renal Failure and Recovery	p. 393
Sepsis-Induced Brain Dysfunction	p. 407
Myocardial Depression in Sepsis and Septic Shock	p. 415
Skeletal Muscle	p. 437
Subject Index	p. 449
Table of Contents provided by Publisher. All Rights Reserved.