Medicinal Chemistry A Biochemical Approach

by Nogrady, Thomas

• ISBN13: 9780195053692
• ISBN10: 0195053699
• Edition: 2nd
• Format: Paperback
• Copyright: 1988-05-19
• Publisher: Oxford University Press

Summary

Emphasizing the molecular action of drugs, this text incorporates recent findings from biochemical pharmacology along with the latest insights into the interactions of drugs with their receptors. It is organized by targets of drug action--endogenous messengers and their receptors, membranes, enzymes, and DNA, among others--and covers all drug groups and their therapeutic applications. This new edition has been thoroughly revised to provide expanded coverage of co-transmitters and neurohormones as well as adenosine receptors and calcium channel blockers. The chapter on drug distribution and metabolism has been extended, and the final chapter on principles of drug design outlines new methods, such as numerical techniques and computer graphics. Other new topics include atrial natriuretic factors, antiarrhythmic drugs, and DNA topoisomerase inhibitory mechanism of antitumor and antibacterial agents. The text is illustrated with hundreds of formulas and tables, and the index includes an extensive listing of drugs.

Table of Contents

Physiochemical Principles of Drug Action

Role and Structure of Water

Solubility

Partition Coefficients

Surface Activity and Drug Effects

Stereochemical Aspects of Drug Action

Electronic Structure and its Effects on Drug Activity

Chemical Bonding and Biological Activity

Quantum Chemical Aspects of Drug Action

Quantitative Structure-Activity Relationships

Receptor-Effector Theories

The Receptor Concept and its History

The Nature of Receptors and the Criteria of Receptor Identity

Definition of Pharmacological Binding Terms

Classical Theories of Concentration-Response Relationships

Molecular Concepts of Receptor function

Methods of Receptor Characterization

Methodological Principles

Indirect Methods of Receptor Characterization

Direct Methods of Receptor Characterization

Data Treatment

Drugs Acting on Neurotransmitters and Their Receptors

Outline of Neuroanatomy and Neurophysiology

Acetylcholine and the Cholinergic Receptors

Norepinephrine and the Adrenergic Receptors

Dopamine and the Dopaminergic Receptors

Serotonin and the Serotonergic Drug Effects

Histamine and the Histamine Receptors

Purinergic Neuromodulation and the Adenosine Receptors

Aminoacid Neurotransmitters and the Drug Effects They Mediate

Drugs Acting on Hormones, Neurohormones, and Their Receptors

Steroid Hormones and Their Receptors

Peptide and Protein Hormones and Neurohormones

Enkephalins, Endorphins, and Opiate Analgesics

Prostaglandins and Thromboxanes

Atrial Natriuretic Factors

Non-Messenger Targets for Drug Action

Excitable Membranes

Cell-Wall Synthesis Inhibitors

Enzymes as Drug Targets

Vitamins

Nucleic Acids as Targets for Drug Action

Drug Distribution and Metabolism

Drug Distribution

Drug Metabolism

Principles of Drug Design

Analogue Synthesis Versus Rational Design

Discovery of "Lead" Compounds

Pharmacophore Identification

Pro-Drugs and "Soft" Drugs

Table of Contents provided by Publisher. All Rights Reserved.