Medicinal Plant Biotechnology, 2 Volume Set From Basic Research to Industrial Applications

by Kayser, Oliver; Quax, Wim J.

• ISBN13: 9783527314430
• ISBN10: 3527314431
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-12-15
• Publisher: Wiley-Blackwell

Summary

This unique overview of plants and transgenic techniques of great scientific, medicinal and economic value for both industry and academia covers the whole spectrum from cell culture techniques, via genetic engineering and secondary product metabolism right up to the use of transgenic plants for the production of bioactive compounds. Practical examples are given throughout, including the production of cancer therapeutics, functional food, and flavor compounds in plants.Of particular interest to the pharmaceutical and biotechnological industries, as well as medicinal chemists, biochemists, and molecular biologists.

Author Biography

Prof. Oliver Kayser studied pharmacy at the University M++nster. He received his PhD and his postdoctoral qualification (Habilitation) from the Free University Berlin in 1997 and 2003. In 2004 he was appointed Assistant Professor at the University Groningen for Pharmaceutical Biology. His research interests are phytochemstry, combinatorial biosynthesis and plant biotechnology. He has published more than 100 peer reviewed papers and proceedings and has authored and edited 5 books.

Professor Wim Quax is head of the laboratory of pharmaceutical biology in the Groningen Research Institute of Pharmacy in the Netherlands. He has published more than 70 peer reviewed papers, and is member of numerous scientific organisations and committees.

Table of Contents

Preface

Foreword

List of Contributors

Color Plates

Linking Plants, Genes, and Biotechnology

The Engineering of Medicinal Plants: Prospects and Limitations of Medicinal Plant Biotechnology

Introduction

Genetic Transformation and Production of Transgenic Plants

Pathway Engineering and Combinatorial Biosynthesis

Bioprocessing

Plant Propagation

Bioanalytics and Metabolomics

Future Prospects.References.

Metabolomics

Introduction

Analytical Methods

Data Handling

The General Set-Up of a Metabolomics Project

Applications

Conclusions

References

HPLC-NMR Techniques for Plant Extract Analysis

Introduction

Hyphenation of Separation Techniques and Spectroscopic Methods

Direct HPLC-NMR Methods

Indirect HPLC-NMR Methods.

HPLC-SPE-NMR

Cryogenically Cooled NMR Probes

Miniaturization

Conclusions

References

Plant-Associated Microorganisms (Endophytes) as a New Source of Bioactive Natural Products

Abstract

Introduction

Why Are There Needs for New Medicines?

Natural Products in Medicine

Endophytic Microbes

Rationale for Plant Selection

Endophytes and Biodiversity

Endophytes and Natural Products

Surprising Results from Molecular Biology Studies on Pestalotiopsis microspora

Concluding Statements

Acknowledgments

References

DNA Profiling of Plants

Introduction

Methodology of Plant DNA Profiling

Applications

Conclusions

References

Bioprospecting: The Search for Bioactive Lead Structures from Nature

Abstract

Introduction

The Function of Secondary Metabolites

Modes of Action

The Utilization of Secondary Metabolites in Medicine

Conclusions

Key references

Biotechnological Approaches for the Production of some Promising Plant-Based Chemotherapeutics

Abstract

Introduction

Production by Plant Cell Cultures

Biotechnological Approaches for Production

Future Prospects

References

Genetic Modifications, Transgenic Plants and Potential of Medicinal Plants in Genetechnology and Biotechnology

In-Vitro Culturing Techniques of Medicinal Plants

Introduction

Basic Methods and Techniques

Protoplast Technology

Special Techniqu

Table of Contents provided by Publisher. All Rights Reserved.