Medicinal Protein Engineering

by Khudyakov; Yury E.

• ISBN13: 9780849373688
• ISBN10: 0849373689
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-12-01
• Publisher: CRC Press

Summary

An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering FieldFrom humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and constructing novel proteins with desired properties. The currently limited understanding of the relationship between protein structure and function greatly hinders rational protein design. However, despite great challenges, protein engineering has become a major molecular discipline with a large array of successful applications to many complex medicinal problems.Medicinal Protein Engineeringsheds light on this largely unchartered field, covering major strategies for engineering of proteins with predetermined biological properties. It discusses computational approachesto protein design and experimental approaches to protein construction. This volume also explores the tight connection between protein and genetic engineering. It moves researchers beyond experimental protein construction and theoretical protein design to the medicinal applications of engineered proteins.  Examines Medicinal Applications of Protein Engineering for the Diagnosis, Treatment, and Prevention of DiseasesFocusing on the application of protein engineering to medicine, this seminal work outlines the appropriate techniques for studying protein properties and building mathematical engineering models of novel vaccines, diagnostic reagents, and therapeutic treatments. As a truly comprehensive assessment of the medical protein engineering research available and its future implications for disease control and prevention, this is an indispensable reference for biological researchers in this groundbreaking field.

Table of Contents

Preface	p. ix
Editor	p. xiii
Contributors	p. xv
Computational Approaches
Web Resources for Protein Analysis	p. 3
Artificial Neural Networks for Therapeutic Protein Engineering	p. 23
Phylogenetics and Medicinal Protein Engineering	p. 57
Clustering and Classification Approaches to Identifying Protein Properties	p. 79
Analysis of Coordinated Substitutions in Proteins	p. 107
Protein Engineering Targets: Vaccine
Tuning the Immune Response to Our Advantage: Design of Vaccines with Tailored Functions	p. 123
Modification of HIV-1 Envelope Glycoprotein to Enhance Immunogenicity	p. 143
Engineering Better Influenza Vaccines: Traditional and New Approaches	p. 169
Construction of Novel Vaccines on the Basis of Virus-Like Particles: Hepatitis B Virus Proteins as Vaccine Carriers	p. 205
Polyomavirus-Derived Virus-Like Particles	p. 249
Papillomavirus-Derived Virus-Like Particles	p. 277
Recombinant Vaccines against Hepatitis Viruses	p. 299
Protein Engineering Targets: Diagnostics and Therapy
Designer Diagnostic Reagents and Allergens	p. 319
Peptide-Based Diagnostic Assays	p. 333
Recombinant Antibodies	p. 353
Protein Engineering for HIV Therapeutics	p. 385
Recombinant Enzymes with New and Improved Properties	p. 407
Special Expression Systems
Production of Pharmaceutical Compounds in Plants	p. 445
Plant Virus Biotechnology Platforms for Expression of Medicinal Proteins	p. 481
Alphaviruses: Multiplicity of Vectors and Their Promising Application as Vaccines and Cancer Therapy Agents	p. 519
Index	p. 551
Table of Contents provided by Ingram. All Rights Reserved.