The Melanocytic Proliferations A Comprehensive Textbook of Pigmented Lesions

by Crowson, A. Neil; Magro, Cynthia M.; Mihm, Martin C.

• ISBN13: 9780470561553
• ISBN10: 0470561556
• Edition: 2nd
• Format: Hardcover
• Copyright: 2014-03-17
• Publisher: Wiley-Blackwell

Summary

The fully revised and enhanced second edition of this monumental, best-selling textbook and reference presents a comprehensive, experience- and evidence-based review of pigmented lesions encompassing the biology, diagnosis, and treatment of melanocytic proliferations and disorders, including malignant melanoma. Incorporating the latest findings from the fields of light microscopy, immunohistochemistry, and flow cytometry, the book brings readers up to date on the most current thinking in the field. Beginning with a discussion of the clinical approach to the patient and a full-color clinical atlas of melanocytic proliferations and their common mimicks, the book's further chapters highlight basic melanocytic biology and morphology, a diagnostic approach to both benign and malignant melanocytic neoplasms, metastatic patterns, and treatment options. The histopathologic interpretation of melanocytic lesions presents one of the most difficult challenges to the anatomic pathologist, a challenge that reflects clinical diagnostic difficulties faced by primary care physicians, dermatologists, and surgeons who rely on the microscopic interpretation to provide definitive diagnosis and the basis for treatment planning. The three world-renowned authors offer both traditional and novel concepts for interpretation, diagnosis, and treatment, from light microscopy to the very latest information about molecular investigational and diagnostic techniques.

Author Biography

Cynthia M. Magro, MD, is Professor of Pathology and Director of Dermatopathology at Weill Medical College of Cornell University in New York City. She has published extensively in the areas of inflammatory skin disease, including collagen vascular disease, vasculitis, cutaneous manifestations of systemic disease, and unique drug hypersensitivity reactions. A significant focus of her work has been lymphocytic infiltrates, including unique forms of drug reactions such as the interstitial granulomatous drug reaction and drug-associated reversible T cell dyscrasia; prelymphomatous cutaneous lymphoid dyscrasias including atypical lymphocytic lobular panniculitis pityriasis lichenoides chronica and pigmented purpuric dermatosis; and malignant T and B cell lymphomas. She has extended her work in immune mechanisms of skin disease and applied it to areas of lung transplantation and pulmonary fibrosis.

Neil Crowson, MD, is Clinical Professor of Dermatology, Pathology, and Surgery, and Director of Dermatopathology at the University of Oklahoma and Regional Medical Laboratory in Tulsa, Oklahoma. His current research interests focus on mechanisms of neoplastic and inflammatory skin disease.

Martin C. Mihm, Jr., MD, is Clinical Professor of Pathology and Dermatology at Harvard Medical School, Massachusetts General Hospital. He is internationally recognized for his expertise in the pathology, diagnosis, and management of pigmented lesions, lymphoid disorders, and vascular tumors. He has worked extensively to understand the host response to melanoma and other tumors. He has served as codirector of the WHO Melanoma Program in addition to his many obligations in translational and clinical research in cutaneous inflammation, tumor vaccination, and pathogenesis of vascular lesions in children.

Table of Contents

Preface/foreword/introduction

1 An Approach To The Clinical Diagnosis Of Malignant Melanoma, Its Recursors, And Its Clinical Mimics

2 The Freckles And Lentigines

3 Benign Acquired Nevi

4 The Dermal Dendritic Melanocytic Proliferations/Dermal Melanocytosis

5 Spitz Nevus

6 Combined Nevus, Deep-Penetrating Nevus, And Plexiform Spindle Cell Nevus

7 Recurrent Melanocytic Nevus

8 The Congenital Nevus

9 Dysplastic Melanocytic Nevi, De Novo Intraepidermal Epithelioid And Lentiginous Melanocytic Dysplasias,And Nevi At Specific Anatomic Sites

10 Malignant Melanoma

11 Conjunctival Melanocytic Proliferations

12 The Use Of Adjunctive Immunoperoxidase, Molecular, And Ultrastructural Studies In The Diagnosis Of Melanocytic  Proliferations

13 The Biology Of  Melanoma

14 The Borderline Nevomelanocytic Proliferation

15 Dermatoscopic Diagnosis Of Melanoma
 
16 Reflectance Confocal Microscopy

17 The Therapy Of Malignant Melanoma